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Öğe Assessment of Mitochondrial Functions and Occurrence of Oxidative Stress at Fibromyalgia Patients(CLINICAL & EXPER RHEUMATOLOGY, 2014) Peksen, Halil; Elden, Hasan; Dogan, Sevil Ceyhan; Cengiz, Ahmet Kivanc; Tuncay, Mehmet Siddik; Salihoglu, Salih…Öğe Effect of Treatment on Sleep Quality in Rheumatoid Arthritis(CLINICAL & EXPER RHEUMATOLOGY, 2014) Tuncay, Mehmet Siddik; Sahin, Ozlem; Peksen, Halil; Salihoglu, Salih; Semiz, Esra…Öğe Effects of childhood psychological trauma on rheumatic diseases(Aves, 2019) Salihoglu, Salih; Dogan, Sevil Ceyhan; Kavakci, OnderObjective: The etiology of rheumatic diseases is unclear, but it is thought that environmental factors added to immunogenetic mechanisms in chronic inflammatory diseases play a role. Many inflammatory disorders, autoimmune diseases, and painful conditions have been shown to be associated with the psychological trauma of childhood. The aim of the present study was to investigate childhood psychological trauma that is considered to be one of the environmental factors that initiate inflammation on patients with rheumatic diseases. Methods: In our study, a total of 440 patients (220 patients who have rheumatic diseases as the case group and 220 patients who have no rheumatic disease as the control group) were examined. The Childhood Trauma Questionnaire-28 (CTQ-28) was administered and was completed by the patients. This was a cross-sectional study design. Results: No statistically significant differences were found between the case and control groups with respect to age, gender, marital status, and educational level. The CTQ-28 scale was found to be significantly higher in patients with rheumatic diseases (ankylosing spondylitis, rheumatoid arthritis, and connective tissue disease) in our study. Conclusion: We think that childhood psychiatric traumas are effective in the etiopathogenesis of rheumatic diseases. To make this relationship more understandable, multidisciplinary research and long-term follow-up studies are needed to examine neuroendocrine, genetic, and epidemiological factors.Öğe Evaluation of sleep quality in rheumatoid arthritis patients(Bayrakol Medical Publisher, 2024) Tuncay, Mehmet Siddik; Sahin, Ozlem; Semiz, Murat; Semiz, Esra; Alim, Bulent; Peksen, Halil; Salihoglu, SalihAim: The purpose of this study was to evaluate treatment effects on sleep quality and fatigue in patients with RA. Besides, we aim to examine possible effects of disease activity, pain and socio-demographic features on sleep quality and fatigue. Material and Methods: In this study, 78 patients diagnosed with RA according to the American Rheumatism Association (ACR) 1987 revised criteria and European League Against Rheumatism (EULAR) criteria were compared with a parallel healthy control group (n=48). All participants were given a sociodemographic questionnaire, the Pittsburgh Sleep Quality Index (PSQI), Multidimensional Assessment of Fatigue Scale (MAF), Visual Analog Scale (VAS), Disease Activity Score 28 (DAS28). Results: The mean duration of diagnosis was 9.10 +/- 8.54 years and the mean score of DAS28 was 3.25 +/- 1.04 in patients with RA. In terms of total PSQI, the differences between two groups were found statistically significant (p=0.001; t=8.023). In terms of MAF, The differences between two groups were found statistically significant (p=0.001; t=3.668). The sleep disturbance and daytime functioning scores were found as 1.86 +/- 0.69, 1.40 +/- 0.83 respectively in nonbiological DMARD group and 1.54 +/- 0.66; 0.84 +/- 0.93 in biological + non -biological DMARD group. There were statistically significant differences between groups (p=0.043; t=2.054, p=0.008; t=2.730). According to correlation analysis between DAS28 and disease duration, a positive correlation has been found (r = 0.297; p = 0.008). Discussion: Patients with RA generally experience more fatigue and have worse sleep quality than healthy individuals. High disease activity can lead to longer sleep latency, reduced daytime functionality, and increased fatigue symptoms.
