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Öğe Breast metastasis in follicular thyroid cancer patient(Wolters Kluwer Medknow Publications, 2022) Erturk, Seyit Ahmet; Hasbek, Zekiye; Duman, Gulhan; Sariakcali, BarisIn this case report, we aimed to present the findings of a follicular thyroid carcinoma patient with breast metastasis, which is rarely reported in the literature. A 33-year-old female who had been operated for thyroid cancer 17 years ago, but whose pathology report could not be reached was suspected of recurrence in the left lobe region of the thyroid gland. Fine-needle aspiration biopsy was done in this region, and the biopsy result was reported as thyroid follicular carcinoma. F-18-fluorodeoxyglucose (F-18-FDG) positron emission tomography/computed tomography (PET/CT) was performed for re-staging before surgery. In the PET/CT, it was found that there was residual thyroid tissue in the right and left lobe region and superior to these lesions in the left side, there were lesions which destruct to the hyoid bone, and there were multiple nodular lesions in both lungs which measured with maximum 15 mm x 12 mm, and all these lesions have increased F-18-FDG uptake. In addition to these lesions, a nodular lesion with the size of similar to 11 mm x10 mm in the upper-middle quadrant of the right breast, and it was showing increased F-18-FDG uptake (maximum standardized uptake value: 3). Pathology results of the left neck region operation materials were reported as papillary and follicular carcinoma of the thyroid gland. Right lumpectomy was performed for the lesion in the right breast during the same session with thyroid operation. The pathology result of this lesion was also reported as metastasis of thyroid follicular cancer. Posttreatment iodine-131 whole-body scan after surgery was reported as there was abnormal accumulation in residual thyroid tissues on the right side of the neck and lung metastases. In patients with thyroid cancer, the possibility of metastasis of the breasts should be considered when there is a lesion in the breast tissue.Öğe Elevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly(Maik Nauka/Interperiodica/Springer, 2021) Dogan, Kubra; Yildiz, Seyma Nur; Sariakcali, Baris; Duman, Gulhan; Bolat, SerkanAlthough systemic inflammation has been linked to acromegaly, little is known about the abnormalities in cytokine networks during the disease. The aim of this study was to evaluate the serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and activin-A in acromegaly, and to investigate the relationship between TNF-alpha, IL-6, activin-A and comorbidities of acromegaly. A total of 56 subjects were recruited to the study. Serum samples were collected from 31 acromegaly patients and 25 healthy control subjects. Serum activin-A, IL-6 and TNF-alpha were determined using the enzyme-linked immunosorbent assay. Circulating levels of activin-A, TNF-alpha, and IL-6 were higher in patients than in the control group. Receiver operating characteristic analysis for activin-A for the differentiation of acromegaly patients from healthy control subjects showed an area under the curve of 0.90. Higher activin-A levels were determined in patients with residual pituitary tumor. These findings provide evidence for the role of activin-A, TNF-alpha and IL-6 in acromegaly. Serum activin-A levels could be used as a novel biomarker to diagnose acromegaly. These findings confirm previous studies that inflammation might be involved in the pathogenesis of acromegaly. Finally, treatment strategies targeting the regulation of inflammation cannot be sufficient alone in reducing comorbidities.Öğe Evaluation of Apoptosis Markers Caspas-8, Cytochrome C Levels in PCOS Patients(Lahore Medical Research Center Llp, 2022) Sariakcali, Baris; Duman, GulhanBackground: Apoptosis is defined as a programmed cell death that eliminates dysfunctional, damaged, and fulfilled cells as a result of a certain stimulus. PCOS, IR, ovarian hyperandrogenism, hyperinsulinemia, and alterations in follicular endocrine signaling may impact the activation, growth, survival, and atresia of follicles. As a result of this impact, polycystic morphology may be observed in the ovaries, follicle development may be inhibited, and anovulation may occur. Aim: We aimed to investigate the relationship between the apoptosis markers caspase-8 and cytochrome-c levels and PCOS patients. Methods: Thirty female patients diagnosed with PCOS and 30 healthy volunteers were included in the study as a control group. Caspase-8 and cytochrome-c levels were measured by ELISA method in the sera of patients and healthy volunteers. Results: 30 PCOS female patients and 30 healthy control group were included in the study. No difference was found between the caspase-8 and cytochrome-c levels of PCOS patients and the caspase-8 and cytochrome-c levels of the healthy control group. (p <0.092, p <0.473). The mean ages of the patient and control groups were similar (mean age of patients: 24, mean age of control: 25). In the patient group, there was no relationship between total testosterone and caspase-8 and cytochrome-c levels (p <0.276, p <0.291). Conclusion: In polycystic ovary patients, the values of caspase-8, the apoptosis marker involved in the extrinsic pathway, and cytochrome-c, which is involved in the intrinsic pathway, similar to the control group. In order to investigate the relationship between PCOS and apoptosis, we suggest that apoptosis markers should be examined in the follicle fluids of PCOS patients.Öğe Evaluation of end-seasonal vitamin d, plasma lipid and other biochemical measurements in professional football players: The case of sivas province in turkey(Mattioli 1885, 2020) Sariakcali, Baris; Ceylan, Levent; Elioz, MuratStudy Objectives: This study aimed to evaluate the end-seasonal blood lipids and some metabolic parameters of the athletes who play football professionally. Methods: Thirty six male professional footballers playing in the Super League and TFF 2nd League (Turkish Football Federation Second League) in Sivas province, aged between 19 and 32 (mean age 23.33 +/- 3.49 years), participated in this research. The athlete age of the players participating in the study is 11.66 +/- 3.72 years. In addition, the athletes participating in the study regularly train 90-120 minutes a day, 6-7 times a week, and approximately 11 months a year. All measurements and venous blood sampling of the participants were collected between 09:00 and 10:00 in the morning after 12-hour fasting in June. The biochemical tests of the participants were obtained with the Beckman DXC-800 model autoanalyzer in the Private Clinical Biochemistry Laboratory and the enzymatic-colorimetric method. IBM SPSS Statistics 24 package software was used to analyze the obtained data. Descriptive statistics of the obtained data were given as mean and standard deviation. Results: Albumin, ALP, ALT, AST, B12 vitamin, Ca, Phosphorus, Creatinine, Mg, Free T3, Sodium, TSH, Ferritin, Folic Acid, Potassium, Free T4, and Uric Acid values of the participant athletes were found to be within normal limits. Conclusion: it was concluded that the HDL cholesterol levels of the smoker athletes were low due to smoking and vitamin D values were low in professional football players.Öğe EVALUATION OF HEAD TRAUMA ON PITUITARY FUNCTION IN PROFESSIONAL SOCCER PLAYERS(Carbone Editore, 2022) Sariakcali, Baris; Ceylan, Levent; Ceviker, AbdulkerimIntroduction: Concussion represents a serious problem in contact sports in professional adult athletes. The hypothesis of this study is to investigate the effects of head traumas on pituitary hormone values by examining the values of pituitary hormones in soccer players with previous head injury. Secondly to evaluate if frequent headshots may also play a role. Materials and methods: A total of 47 professional soccer players (SP) , and 32 individuals who do not play sports professionally with no history of head injury (CG) participated in the study. After completing the informed consent forms, soccer history, head trauma, concussion questioning were applied to the athletes with the HeadCount-12 Month Questionnaire adapted by Lipton et al. (2013) to determine the number of headshots of each soccer players during the last 12 months. Results: When we compare the averages of SP and CG biochemical and hormonal parameters, there were significant differences in cortisol and prolactin levels (p 0.05). No significant difference was found in any other parameter (p 0.05). Conclusions: Pituitary function is preserved in professional soccer players. Previous head trauma and frequent headshots do not seem to have a role in pituitary dysfunction.Öğe Evaluation of the Relationship Between Mobile Phone Usage and miRNA-574-5p and miRNA-30C-5p Levels in Thyroid Cancer Patients(Galenos Publ House, 2024) Hasbek, Zekiye; Tas, Ayca; Erturk, Seyit Ahmet; Sariakcali, Baris; Babacan, Ozge Ulas; Duman, Gulhan; Silig, YavuzObjectives: This study aimed to evaluate the relationship between mobile phone usage and miRNA-574-5p and miRNA-30C-5p levels in patients diagnosed with differentiated thyroid cancer (DTC). Methods: Fifty patients diagnosed with DTC and 50 healthy volunteers were included in the study. miRNA-574-5p and miRNA-30C-5p gene expression levels in the blood of all subjects were analyzed by real time-polymerase chain reaction, and a questionnaire including various questions was administered to both groups. Results: Although there was a 7.60 -fold increase in miRNA-30C-5p gene expression levels in the patient group compared with the control group, it was not found to be statistically significant. Considering the miRNA-574-5p gene expression levels, although there was a 2.96 -fold increase in the patient group compared with the control group, no significant relationship was found. In our study, 85% of our patients were using mobile phones with internet access, whereas 98% of our healthy volunteers were using mobile phones (p<0.05). While 53.5% of the patients had their mobile phones with them while they were sleeping, this rate was 83.7% in healthy volunteers (p<0.05). However, 93.9% of the healthy volunteers did not have a Wi-Fi device in their bedrooms, and this rate was 75% in the patient group (p<0.05). Conclusion: Although miRNA-30C-5p and miRNA-574-5p gene expression levels were higher in patients than in healthy volunteers, the differences were not statistically significant. Although there was no significant difference in miRNA levels, we believe that due to the higher rate of Wi-Fi device presence in bedrooms in patients compared with healthy volunteers, the effects of electromagnetic radiation on the thyroid can be reduced by paying attention to this simple change.Öğe Serum WNT-induced secreted protein 1 level as a potential biomarker for thyroid nodules(Zaslavsky Publishing House, 2021) Duman, Gulhan; Sariakcali, BarisBackground. Thyroid nodule (TN) is a common thyroid disease worldwide, and it has increased significantly last decades. Most TNs are usually incidental findings of asymptomatic, benign lesions discovered by imaging modalities performed for reasons unrelated to thyroid diseases. The purpose of this study was to investigate the value of serum WNT-induced secreted protein 1 (WISP1) level as a supporting biomarker to perform differential diagnosis of benign and non-benign thyroid nodules. Materials and methods. The study was completed with the 89 patients undergone fine needle aspiration biopsy and 43 controls. The patients were composed of 96 (72.7 %) females and 36 (27.3 %) males. And they were divided into 2 group according to the Bethesda cytological evaluation as Benign (Bethesda 2) and Non-Benign (Bethesda 3–6) groups. Their serum WISP1 levels were measured by an ELISA method. Results. There were 58 (43.9 %) patients in Benign (Bethesda 2) and 31 (23.5 %) in non-Benign (Bethesda 3–6) groups. In the contrary nodule size was bigger in the Non-benign group than that benign group (p = 0.006). The serum WISP1 level in the Benign (Bethesda 2) group was significantly higher than that in the and Non-Benign (Bethesda 3–6) group, and controls (p < 0). The difference between benign and non-benign group accordingly to their echogenicitiy was significant (p < 0.05). In benign group there was 76.9 % mixed echoic nodules, 76.7 % isoechoic nodules 68.4 % isohypoechoic nodules and 35.7 % hypoechoic nodules. In the non-benign group, the highest hypoechoic echo (64.3 %), the least mixed echo (23.1 %), while in the benign group, the most mixed echo (76.9 %), the least hypoechoic echo (35.7 %) was present. There was no relation between WISP1 levels and echogenicity with Kruskal-Wallis H test. Conclusions. According to the preliminary results of current study, addition of serum WISP1 measurement to the differential diagnostic work-up of thyroid nodules patients may provide supportive information. In thyroid nodules patients with Benign (Bethesda 2) category of cytological evaluation, a higher level of serum WISP1 may support cytological diagnosis. © 2021. The Authors.Öğe Subacute thyroid and SARS-CoV-2 relationship(Lahore Medical & Dental Coll, 2021) Sariakcali, Baris; Duman, GulhanBackground: This study aims to research the relationship of subacute thyroiditis with SARS-CoV-2. The prevailing risks of predisposition to certain diseases or organ dysfunctions even after surviving the disease are discussed more frequently each day. Aim: Could SARS-CoV-2 be considered as a triggering factor in patients diagnosed with subacute thyroiditis? Investigating the relationship between subacute thyroiditis and SARS-CoV-2. Methods: Thirty-three patients diagnosed with subacute thyroiditis between 01.11.2020 and 01.04.2020 were included in the study. Patients who tested positive for SARS-CoV-2 throughout the examinations performed at the time of the diagnosis for subacute thyroiditis and patients who were previously diagnosed with Covid-19, who tested positive for SARS-CoV-2, and subsequently diagnosed with subacute thyroiditis within 30 days have been included in the study. Clinical evaluation of the patient, thyroid hormone values, CRP values, sedimentation levels, and thyroid ultrasonography images were considered to diagnose subacute thyroiditis; patients whose results were compatible with subacute thyroiditis were diagnosed with subacute thyroiditis, and they were included in the study. Results: It was found that 5 (15%) of the 33 patients included in the study had Covid-19 disease before the diagnosis of subacute thyroiditis and were isolated for the SARS-CoV-2 virus. Conclusion: The SARS-CoV-2 virus can be considered a triggering factor for subacute thyroiditis. We believe that researching this relationship on a broader patient population will bring more clarity to the subject. Although encountered in only one of our cases, the Coronavirus vaccine and SAT relationship may shed light on future studies.Öğe The dual impact: physiological and psychological effects of rapid weight loss in wrestling(Frontiers Media Sa, 2025) Sariakcali, Baris; Sahin, Fatma Nese; Basoglu, Burhan; Ceylan, Levent; Guler, Ozkan; Yamak, Bade; Arikan, GoekhanIntroduction: Athletes competing in weight-class sports often seek to gain an advantage by competing at lower weights. Athletes competing in weight-class sports often seek to gain an advantage by competing at lower weights. To achieve this, they aim to lose weight during the competition period, leading to various physiological and psychological changes. This study aimed to investigate the biochemical, hormonal, and psychological effects of weight reduction in elite wrestlers during the competition phase. Methods: Thirty-seven elite male free style wrestlers (age: 19.02 +/- 1.27) participated in the study. Samples were collected 5 days before and on the day of the match. Results: A significant decrease in body weight was observed (p < 0.05). Levels of creatine, BUN, sodium, hematocrit, hemoglobin, LDH, and cortisol increased, while albumin, testosterone, and FSH levels decreased. There were no significant differences in potassium, ALT, AST, TSH levels. State and trait anxiety scores of the wrestlers increased significantly during the RWL period. Conclusion: The study concluded that elite wrestlers experienced significant changes in physiological and psychological parameters during the competition periods. These findings underscore the importance of careful monitoring of RWL strategies by coaches and athletes to mitigate the adverse effects on nutritional status, psychological well-being, and physical performance.Öğe The impact of Dicer, Drosha, and Exportin-5 levels in polycystic ovary syndrome (PCOS) diagnosis and phenotyping(Via Medica, 2022) Duman, Gulhan; Sariakcali, Baris; Ersan, Serpil; Bakir, SevtapIntroduction: Polycystic ovary syndrome (PCOS) is a very common heterogeneous endocrine and gynaecological disease in reproductive women. Early identification and treatment of patients are necessary to prevent future cardiometabolic and reproductive complications. In our study, we aimed to investigate whether Drosha, Exportin-5 (XPO5), and Dicer, which are involved in miRNA formation, are useful markers in the diagnosis of the disease. Material and methods: Patients who presented to our clinic with complaints such as menstrual irregularity, hirsutism, and acne were diagnosed with polycystic ovary after excluding other possible diagnoses, and if they meet two-thirds of the Rotterdam diagnostic criteria, they were included in the study. Thirty patients with polycystic ovaries and 35 healthy controls were included in this study. Results: The mean values of XPO5, Drosha, and Dicer markers were significantly higher in the PCOS group when compared with the control group. With an XPO5 value > 1.70, we found the PCOS with 94% probability, 86.7% sensitivity, and 91.4% specificity. Moreover, if the Drosha value was > 0.166, it was expected that the patient would be diagnosed as PCOS with a probability of 75%, with 66.7% sensitivity and 71.4% specifidty. A statistically significant cut-off value could not be obtained for Dicer. Conclusions: In our study, the levels of all three markers were found to be significantly higher in the PCOS group compared to the control group. It suggests that they can be used in the early diagnosis of PCOS patients without full-blown disease. However, this preliminary study should be supported by larger-scale studies.Öğe The Usefulness of Monocyte-to-High Density Lipoprotein and Neutrophil-to-Lymphocyte Ratio in Diabetic Macular Edema Prediction and Early anti-VEGF Treatment Response(Taylor & Francis Inc, 2022) Yeter, Duygu Yalinbas; Eroglu, Serap; Sariakcali, Baris; Bozali, Erman; Ozec, Ayse Vural; Erdogan, HaydarPurpose: To determine the association of monocyte-to-high-density lipoprotein ratio (MHR) and neutrophil-to-lymphocyte ratio (NLR) with diabetic macular edema (DME) and early anti-VEGF treatment response. Material methods: This was a retrospective and cross-sectional study conducted with 143 patients with diabetes mellitus (53 diabetic retinopathy with DME, 38 diabetic retinopathy without DME, and 52 without diabetic retinopathy). Results: 13.9 was the best cutoff value to predict DME for MHR, and 2 was for NLR (59% and 75% sensitivity and 81% and 59% specificity, respectively). Logistic regression analysis showed that NLR >= 2 and MHR >= 13.9 were significantly associated with DME prediction. However, neither NLR >= 2 nor MHR >= 13.9 was associated with central retinal thickness(CRT) or best corrected visual acuity(BCVA) outcomes after anti-VEGF treatment. On the other hand, increased NLR was associated with inferior CRT outcomes. Conclusion: MHR and NLR were simple and cost-effective biomarkers to predict DME. Moreover, higher NLR may contribute to poor CRT outcomes.Öğe Thyroid Nodules Located in the Lower Pole Have a Higher Risk of Malignancy than Located in the Isthmus: A Single-Center Experience(Hindawi Ltd, 2021) Duman, Gulhan; Sariakcali, BarisPurpose. The aim of our study is to investigate whether thyroid nodules (TNs) localization has value as a predictor of malignancy. Ultrasonography provides very valuable information in the evaluation of TNs, but it does not correlate perfectly with histopathologic findings. Therefore, studies that will include new diagnostic methods that can improve these unknowns can be welcomed gratefully. Methods. This study was carried out retrospectively in a tertiary care center from September 2016 to January 2020. The study included 862 adult patients who have one or more nodules. Ultrasonography of characteristics of nodules such as echogenicity, content, margins, calcifications, size, and localization was recorded. Fine-needle aspiration biopsy (FNAB) was performed on dominant and suspicious 1142 nodules. Results. The patients were composed of 692 (80.3%) females and 170 (19.7%) males. Compared to nodules located in the isthmus; the malignancy risk increased 8.39 (OR: 8.39 (2.34-30.12), p = 0.001) times in the lower pole, 4.27 (OR: 4.27 (1.16-15.72), p = 0.029), times in the middle pole, 8.09 (OR: 8.09 (2.11-30.94), p = 0.002) times in the upper pole, and 7.63 (OR: 7.63 (1.95-29.81), p = 0.003) times in the nodules covering the whole of the lobe. Although the most nodular location was in the middle pole, the risk of malignancy was less than that in the lower and upper poles. Conclusions. Unlike the other localization studies, we found a higher risk of malignancy in the lower and similarly upper thyroid poles. Besides well-defined malignancy indicators in the literature and guidelines, localization information is promising for this purpose in the future.
