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Öğe A 53-year-old female with bladder leiomyoma: A rare case and review of the literature(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Asdemir, Tugba Yildiz; Saygin, Huseyin; Korgali, Esat; Cicek, ResulLeiomyoma as a benign tumor of the urinary bladder, is uncommon and usually presents with obstructive voiding symptoms or irritative urinary symptoms. A 53-year-old woman was hospitalized to the general surgery clinic due to abdominal pain. During her contrast-enhanced computed tomography (CT) examination, incidentally, a mass on the left anterosuperolateral side of the bladder wall was revealed. No significant finding was detected on physical examination. There was only microscopic hematuria as a result of urinalysis. Contrast-enhanced CT confirmed the presence of a mass on the left anterosuperolateral side of the bladder wall without evidence of extravesical extension and showed a well-delineated 2,6 cm x 2,4 cm endovesical bladder tumor arising from the left anterosuperolateral bladder wall and there was a thickening of the urinary bladder wall. On cystoscopy, an intraluminally protruding, rounded, smooth, sessile solid mass, 2,5 cm in diameter and covered by normal bladder mucosa, was seen. She underwent an uneventful transurethral resection of bladder tumor (TURBT) and histological examination revealed intersecting fascicles of smooth muscle without any evidence of malignant change, and thus diagnosis of leiomyoma was confirmed. Confirmation of the diagnosis may be difficult due to the poor yield of cold cup biopsy. In our case, transurethral resection (TUR) was diagnostic.Öğe A Cause of Right-Sided Flank Pain: Retrocaval Ureter(Erciyes Univ Sch Medicine, 2024) Ergin, Ismail Emre; Ozturk, Abuzer; Velibeyoglu, Arslan Fatih; Saygin, HuseyinBackground: The retrocaval ureter represents a rare congenital anomaly that occurs 0.1% of the population and causes progressive ureterohydronephrosis, most of which asymptomatic. Case Report: In this case report, the retrocaval ureter detected in an adult male complaining of right-sided colicky flank pain is discussed. Conclusion: This condition, whose main cause is an anomaly in the development of vena cava, is easily diagnosed with imaging methods, and its symptoms can be completely corrected with surgical treatment.Öğe Comparison of Prostate Specific Antigen and Neuropeptide Y Parameters in Patients with Prostate Cancer(Galenos Publ House, 2024) Ozturk, Abuzer; Saygin, Huseyin; Asdemir, Aydemir; Bolat, Serkan; Ergin, Ismail Emre; Kirac, Emre; Korgali, EsatObjective: Prostate cancer is a solid tumor that can be fatal in men. Early detection and proper management are essential for improving outcomes and reducing mortality rates associated with this disease. This study aimed to evaluate the potential of neuropeptide Y (NPY) as a biomarker to enhance the effectiveness of prostate specific antigen (PSA) testing in diagnosing and predicting prostate cancer prognosis. NPY, a well-known sympathetic neurotransmitter, possesses growth-promoting and angiogenic properties in various cell types, including those relevant to prostate cancer. Additionally, NPY has been linked to neuroendocrine differentiation of prostate cancer cells. By comparing the efficacy of PSA testing alone with the addition of NPY, this study aimed to determine whether NPY could offer additional predictive value for prostate cancer progression and prognosis. Materials and Methods: This study involved 90 patients each diagnosed with localized prostate cancer (LPC), metastatic prostate cancer (mPC) at diagnosis, and metastatic castration-resistant prostate cancer (mCRPC) who visited our urology clinic between 2022 and 2023. Blood samples were collected from all participants between 08:00 and 09:00 after a 12 hour fast. In the LPC and mPC groups, samples were collected upon diagnosis, whereas in the mCRPC group, samples were collected upon development of treatment resistance. NPY levels in blood samples were analyzed using enzyme-linked immunosorbent assay method. Serum NPY levels were compared between the LPC, mPC, and mCRPC groups. Results: PSA values were calculated as 12.6 (7.08-32.47) ng/L in the LPC group, 159 (73.1-405.2) ng/L in the mPC group, and 38.33 (18.4-132) ng/L in the mCRPC group, with a statistically significant difference between the groups (p<0.001). The average NPY values were 351.3 +/- 162.7 ng/L in the LPC group, 276.5 +/- 85 ng/L in the mPC group, and 272.13 +/- 94.7 ng/L in the mCRPC group. NPY values were found to be statistically significantly higher in the LPC group (p=0.018). Conclusion: The serum NPY levels were notably elevated in the LPC group compared with the mPC and mCRPC groups. This finding implies a potential association between low NPY levels and mPC as well as mCRPC.Öğe Correlation Between PSA Density and Multiparametric Prostate MRI in the Diagnosis of Prostate Cancer(Galenos Publ House, 2024) Aslanoglu, Ahmet; Saygin, Huseyin; Ozturk, Abuzer; Ergin, Ismail Emre; Asdemir, Aydemir; Velibeyoglu, Arslan Fatih; Korgali, EsatObjective: In the diagnosis of prostate cancer, only digital rectal examination and prostate -specific antigen (PSA) testing cause unnecessary prostate biopsies, excessive cost, and treatment burden. Therefore, PSA density (PSAD) and multiparametric magnetic resonance imaging (mp-MRI) of the prostate are becoming common. In this study, we aimed to investigate the predictiveness of PSAD and mp-MRI of the prostate in the diagnosis of prostate cancer, which are non-invasive diagnostic methods. Materials and Methods: The files of 193 patients who applied to the urology outpatient clinic for approximately 5 years were reviewed and evaluated retrospectively. Serum PSAD values and prostate imaging reporting and data system (PIRADS) scores were recorded. Prostate biopsies were performed. The cut-off value for PSAD was 0.15 ng/mL/cc. Patients with <0.15 were divided into group 1, and those with >= 0.15 were divided into group 2. Patients with a PIRADS score of 3 were divided into the suspicious group, and patients with a PIRADS score of 4 or 5 were divided into the risky group. Results: Prostate volume, PSA, and PSAD were significantly different between the benign and malignant groups. PSAD was positively correlated with the PIRADS score. Of the 123 patients with a PIRADS score of 3, 82.9% had benign prostatic enlargement (BPE) and 17.1% had prostate cancer. Of the 70 patients with a PIRADS score of 4 or 5, 45.7% had BPE and 54.3% had prostate cancer (p<0.001). Clinically significant prostate cancer rates were significantly different between the PSA score groups and were also different for PIRADS (p<0.001). The sensitivity and specificity of PSAD in the diagnosis of prostate cancer were 67.8% and 64.9%, respectively. The sensitivity and specificity of the PIRADS score in the diagnosis of prostate cancer were 64.4% and 76.1%, respectively. When these two parameters were used in combination, the specificity was 87.3% and the sensitivity was 81.4% in the presence of at least one. Conclusion: According to the data of the study, it was concluded that PSAD and PRIDAS scores are complementary diagnostic methods in the diagnosis of prostate cancer and are indispensable elements in the diagnosis. PSAD and PRIDAS scores are important diagnostic parameters in making the biopsy decision in the diagnosis of prostate cancer and help to prevent unnecessary prostate biopsies.Öğe Determination of kidney stone prevalence in Sivas city center: A retrospective research(Bayrakol Medical Publisher, 2021) Saygin, Huseyin; Cinar, Ziynet; Ozturk, Abuzer; Kirac, Emre; Ergin, Ismail Emre; Velibeyoglu, Arslan Fatih; Korgali, EsatAim: In this study, it was aimed to determine the prevalence of urinary stone disease (USD) in the center of Sivas based on data from patients who were diagnosed with USD at the urology clinic of the hospitals in Sivas center. Material and Methods: This is a retrospective study. The records of the patients who applied to the Urology Department of the Faculty of Medicine of Sivas Cumhuriyet University and Sivas Numune Hospital i between 2014 and 2019 were examined in this research. Evaluations of statistics were made on the basis of data to determine the prevalence of USD in Sivas center. Results: The data of 30218 people (20114 mates and 10104 females) who applied to the Urology Policlinic of Sivas Central Hospitals in 2014 and 2019 were evaluated for USD. Also, 4739 patients who were operated in both hospitals were evaluated according to gender and age. Results significantly increased with age for both genders (p<0.05). On the other hand, the number of people treated with Extracorporeal Shock Wave Lithotripsy (ESWL) in both hospitals was 1543. They were evaluated by age and gender, and results were not statistically significant (p>0.05). The prevalence of USD in the Sivas Center was determined as 8%. Agglomeration was observed in 31-70 age groups in both sexes. The results showed that the risk of USD was twice as high among men in both Numune Hospital and C.U Hospital. Discussion: Our country is one of the regions where USD is common, but there are not enough prevalence studies on this subject. It is a known fact that processes of diseases and treatment put a great burden on the economy of the country. Knowing the frequency of the disease makes it easier to take precautions. More epidemiological studies in larger populations are needed to direct health policies.Öğe Effects of electronic cigarettes on oxidative stress markers in the rat kidney tissues(Kare Publishing, 2022) Dogan, Kubra; Saygin, Huseyin; Yalman, YucelObjectives: Electronic cigarettes (e-cigarettes) are an alternative to traditional cigarettes. Although numerous studies have been conducted regarding the effects of traditional cigarettes on oxidative stress biomarkers in the kidney, there are only a few studies on the effects of e-cigarettes. Methods: A total of 24 male Wistar albino rats were separated into three groups: Group 1 was treated with traditional cigarettes, Group 2 with e-cigarettes, and Group 3 formed the control group. Kidney homogenates and plasma samples were obtained, and the glutathione peroxidase, protein carbonyl, superoxide dismutase (SOD), catalase (CAT), lipid hydroperoxide (LPO), and symmetric dimethylarginine (SDMA) levels were examined. Results: Higher plasma SDMA levels were determined in Group 1 and Group 2 compared with Group 3 (<0.0001). Higher SOD activity was found in Group 1 compared with Group 2 (p=0.0094). Lower CAT activity was found in Group 1 compared with both Group 2 (p=0.0035) and Group 3 (p<0.0001). Higher LPO levels were determined in the traditional cigarette smoking group compared with the control group (p=0.028), and no statistically significant difference was found between the e-cigarette and the control groups. Conclusion: E-cigarettes and traditional cigarettes are associated with the dysregulation of particular oxidative stress markers in the kidney. However, e-cigarettes have less effect on some oxidative stress markers than traditional ciga-rettes. Long-term use of traditional cigarettes and e-cigarettes causes oxidative stress, which may lead to renal tissue damage and diminished kidney function. © 2022, Kare Publishing. All rights reserved.Öğe Effects of psoriasis and metabolic syndrome on male sexual functions(Imr Press, 2021) Saygin, Huseyin; Tosun, Mustafa; Ozturk, Abuzer; Ergin, Ismail Emre; Kirac, Emre; Asdemir, Aydemir; Velibeyoglu, Arslan FatihBackground and Objective: Psoriasis is a chronic inflammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis. Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded. Results: IIEF, HAM-D scores and MetS were significantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a significant negative correlation with age, HAM-D and PASI scores (r = -0.405, -0.217 and -0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment. Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.Öğe Fluoroquinolone Resistance Level in Rectal Swab Taken Before Transrectal Ultrasound Prostate Biopsy(Galenos Publ House, 2022) Saygin, Huseyin; Ozturk, Abuzer; Asdemir, Aydemir; Ergin, Ismail Emre; Velibeyoglu, Arslan Fatih; Kirac, Emre; Hasbek, MursitObjective: It has been shown that antibiotic prophylaxis before transrectal ultrasound prostate biopsy (TRUS-Bx) reduces the incidence of post-biopsy infectious complications. Without the superiority of a particular antibiotic regimen, there are differences in the antibiotic regimens used by clinics. However, recently, there have been serious concerns about TRUS-Bx-related infectious complications due to the increase in fluoroquinolone (FQ)-resistant bacterial strains. To overcome this global problem, alternative antibiotic prophylaxis should be investigated and appropriate antibiotic management should be applied in patients who will undergo TRUS-Bx. This study aimed to determine the antibiotic susceptibility of the rectal flora based on rectal cultures before TRUS-Bx, to systematically determine the basic prevalence of FQ resistance, to investigate the relationship between FQ resistance and the risk of infection after TRUS-Bx, and to determine the susceptibility of Fosfomycin and trimethoprim-sulfamethoxazole (TMP-SMX) as an alternative to the FQ group.Materials and Methods: Rectal swab cultures were taken from each patient to undergo TRUS-Bx two days before the procedure. Two daily doses of 500 mg ciprofloxacin were given orally for one week, starting one hour before the procedure. All patients underwent 12 core biopsies.Results: Antibiograms obtained from rectal swabs showed sensitivity to FQ in 78 patients (89.7%), to Fosfomycin in 85 patients (97.7%), to TMP-SMX in 78 patients (89.7%).Conclusion: Although different antibiotic prophylaxis methods are discussed due to FQ resistance in today's medical practices, FQ sensitivity continues at a high rate of 89.7% in our region and still seems to be a viable prophylaxis method.Öğe Giant prostatic urethral stones in a young patient(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Saygin, Huseyin; Korgali, Esat; Asdemir, Tugba YildizGiant prostatic urethral stones have been reported as a very rare entity, and the etiology of these stones is not clear. Here we report a case of a 44-year-old man with giant multiple prostatic urethral stones presented with voiding difficulty and recurrent urinary tract infections. A big stone in the right cavity was observed endoscopically, some of them protruding into the urethra, and two other big stones in the left cavity were observed after resection of the surface tissue on the stones on the prostate. Following cystoscopy, giant prostatic stones were removed endoscopically after holmium-YAG laser lithotripsy.Öğe Investigation of Effects of Essential Oil from Berries of Juniperus excelsa Bieb. Subsp excelsa (Cupressaceae) on Angiogenesis in Shell-less Chick Embryo (CAM) Culture(TAYLOR & FRANCIS LTD, 2015) Goze, Aysegul; Gose, Ismihan; Alim, Ahmet; Saygin, Huseyin; Alim, Betul AycanThe aim of this study was to investigate the effect of essential oil of the berries from Juniperus excelsa Bieb. subsp. excelsa (Cupressaceae) to the vascularization systems of the chick embryos in a chorioallantoic membrane model. The berries of J. excelsa were subjected to hydrodistillation. 50 mu l of essential oil were applied to the center of the blastodisc using a precision micropipette prior to the transfer of shell-less cultures to the incubator. Antiangiogenic effect of essential oil of the study plant was determined with the use of the chick chorioallantoic membrane model. Numbers of main, branching and capillary blood vessels were counted. In the statistical analysis, when the groups were compared with regard to the main blood vessel (MBV) and branch blood vessel (BBV) development, no significant difference (p>0.05) was observed. However, when the groups were compared with regard to capillary vessel (CV) development, the difference between the data of the groups was found significant (p<0.05). This study examined the effect of exposure J. excelsa essential oil on extraembryonic vascular development in the chick embryo area vasculosa (AV) in shell-less culture for the first time. Essential oil of the berries from J. excelsa has antiangiogenic effect.Öğe Late diagnosed congenital anterior urethral diverticulum in a male teenager: A case report(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Saygin, Huseyin; Korgali, Esat; Cicek, ResulIn this case report we present the case of an 18-year-old boy with a congenital anterior urethral diverticulum. This is a rare condition in males which can lead to obstructive lower urinary tract symptoms and urosepsis. Diagnosis is made by urethroscopy and radiological imaging. Surgical treatment can be open or endoscopic. Long-term follow up is required to check for reoccurrence of the obstruction.Öğe Macro hematoma after micro percutaneous nephrolithotomy: A case report(Bayrakol Medical Publisher, 2021) Asdemir, Aydemir; Saygin, Huseyin; Korgali, Esat; Cicek, ResulThe micropercutaneous nephrolithotomy (mPNL, microperc) method was developed in order to prevent complications. In our clinic, we performed microperc on a 39-year-old man who expelled renal stone. During the microperc procedure, lower pole calyceal access was successfully obtained to get direct access to the stone by using 4.8Fr microperc needle. The patient's hemoglobin dropped from 16.8 to 9.6 gr/dl about 6 hours after surgery. A new computerised tomography (CT) scan demonstrated a large retroperitoneal hematoma measuring 182x97x92 mm. When we performed retroperitoneal exploration, we saw a bleeding area due to the entrance of microperc needle. Then, we controlled the hemorrhage. The patient's hemodynamics remained stable and he did not need any blood transfusion after exploration. Based on this case, it appears reasonable to allow open surgery after microperc to control macro hematoma.Öğe Relationship Between the Visceral Adiposity Index and Peyronie's Disease(Galenos Publ House, 2023) Kolukcu, Engin; Bolat, Mustafa Suat; Demir, Mehmet; Sarikaya, Kubilay; Saygin, HuseyinObjective: We aimed to investigate the relationship between Peyronie's disease (PD) and the visceral adiposity index (VAI), which is thought to predict visceral obesity homogeneously.Materials and Methods: We included 102 healthy volunteers (Group 1) and 89 patients with PD (Group 2) in this retrospective study. We recorded demographic, anthropometric, and clinical data, including age, comorbidity, International Index of Erectile Function (IIEF) score, waist circumference (WC), body mass index (BMI), visceral adiposity index testosterone (VAI), serum fasting glucose, high-density lipoprotein (HDL), and triglyceride (TG). For Group 2 participants, plaque size, duration of symptoms, and degree of penile curvature were recorded.Results: The mean ages of Group 1 and Group 2 were 55.12 +/- 9.51 years and 54.79 +/- 9.99 years, respectively (p>0.05). The mean BMI, WC, VAI, fasting glucose, and TG values were significantly higher in Group 2 (p<0.001, p=0.004, p=0.001, p=0.001, and p=0.003, respectively). The mean HDL values between the groups were similar (p>0.05). The mean IIEF score was lower in Group 2 than in Group 1 (p=0.008). An increase of 1 unit in the VAI value increases the probability of having PD 1.2 times (p=0.001). Each VAI integer increase decreased 1.25 points in the IIEF score, a 1 mm increase in plaque size, and a 1.98-degree increase in curvature.Conclusion: Our study has shown that VAI can be used as a reliable, independent risk factor for plaque size and penile curvature in patients with patients with PD.Öğe The effect of smoking and electronic cigarettes on rat testicles(Elsevier Espana Slu, 2023) Saygin, Huseyin; Korgali, Esat; Koc, Tulay; Dogan, KubraObjective: After the negative effects of smoking on public health were proven, smoking cessation campaigns were initiated by health ministries and non-governmental organizations. Many drugs have been tried to reduce the addiction to smoking and the nicotine contained in it. Recently, e-cigarettes (EC) are widely used for smoking cessation efforts, although the effects and possible harms are not fully known. In our study, we planned to show the effect of cigarette and EC smoke on the male urogenital system. Methods: Adult male wistar rats were exposed to cigarette and EC smoke in a specially designed glass bell jar. Urine cotinine levels, testicular weights, gonadosomatic index, sperm count and sperm motility, testicular histology, and biochemical findings were compared with the control group. Results: In some rats in the cigarette and EC group, the seminiferous tubules were disorganized, and the germ cells and Sertoli cells were separated and shed. Stopped germ cell separation, cavity formation, necrosis, fibrosis, and atrophy were observed in severe cases. Higher PCO levels were found in the cigarette group compared to controls. Tissue homogenates levels of LPO were higher in both EC and cigarette groups compared to controls. No significant differences were observed between groups in terms of sperm motility and sperm count. Conclusion: Cigarette and EC liquid can increase oxidative stress as well as cause morphological changes in the testicle. To be a safe option in smoking cessation studies, its effect on people needs to be enlightened. (c) 2023 Asociacion Espanola de Androlog ' ia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.Öğe Xanthoma of the Bladder-A Rare Entity(Galenos Publ House, 2024) Dogan, Mehmet Akif; Saygin, Huseyin; Kaya, Seyhmus; Aydin, Sedanur; Velibeyoglu, Arslan FatihXanthoma is a non-neoplastic lesion caused by an abnormal focal aggregation of lipid-containing histiocytes in tissues. Typically associated with hyperlipidemia, it can also be observed in patients with normal lipid levels. Bladder xanthoma is a rare lesion. It is usually asymptomatic and is usually encountered incidentally. It may be isolated or associated with urothelial carcinoma of the urinary bladder. In this case report, we present an incidental case of bladder xanthoma in a 64-year-old patient who underwent surgical treatment due to lower urinary tract symptoms and an investigation of the etiology of hematuria.
