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Öğe A cross-sectional study on the comparison of serum SIRT-1 and MMP-9 levels of patients with bronchiectasis and healthy controls(Professional Medical Publications, 2025) Bakir, Deniz; Bedir, Mustafa D.; Ozbek, Dilara Ulger; Seyfikli, ZehraBackground & Objectives: Bronchiectasis is the permanent enlargement of the bronchi following damage to the respiratory tract (bronchi) in the lungs. Bronchiectasis not associated with cystic fibrosis is gaining an increasing place among chronic respiratory diseases worldwide. The purpose of this study was to identify the levels of MMP-9, known to cause bronchial damage in chronic pulmonary illness, and SIRT-1, an anti-aging and anti-infective regulatory protein, in patients with bronchiectasis and to evaluate the importance of these biomarkers in diagnosis. Methods: This cross-sectional study was conducted in the Chest Diseases Clinic of Sivas Cumhuriyet University Medical Faculty Hospital between November 2020 and September 2022. We recruited 30 patients with bronchiectasis whose diagnosis was verified by high-resolution chest CT scan and 30 healthy controls. SIRT-1 and MMP-9 levels in the serum of the study group were determined by the ELISA method. Results: SIRT-1 and MMP-9 concentrations were found to be statistically significant. In comparison to the control group, it was observed that the bronchiectasis group had a lower serum SIRT-1 levels (p<0.001). The bronchiectasis group had higher serum MMP-9 values than the control group (p<0.001). Age-related differences in SIRT-1 and MMP-9 concentrations were not observed. No correlation was found between MMP-9 and SIRT-1. The results of Receiver Operating Characteristic (ROC) analysis indicated that MMP-9 has relatively high sensitivities. Conclusions: We concluded that, higher inflammation elevates MMP-9 levels while decreasing SIRT-1 levels. MMP-9 and SIRT-1 may be potential biomarkers in the diagnosis of bronchiectasis. © 2025, Professional Medical Publications. All rights reserved.Öğe Assessment of exposure to tobacco smoke: Measurement of exhaled carbon monoxide and hair nicotine(Turkiye Klinikleri, 2012) Doruk, Sibel; Demirtaş, Ibrahim; Akşit, Hüseyin; Erkorkmaz, Ünal; Seyfikli, ZehraAim: To investigate the effect of tobacco smoke (TS) exposure on the quantity of exhaled carbon monoxide (eCO) and hair nicotine (HN) and to evaluate the relationship between these values. Materials and methods: Included in the study were 96 subjects (64 male, 32 female) divided into 3 groups. The subjects in Group 1 (n = 46) were current smokers, and the subjects in Group 2 (n = 20) and Group 3 (n = 30) were nonsmokers with or without environmental TS exposure, respectively. The eCO level of all of the subjects was measured with a breath CO monitor. Gas chromatography/mass spectrometry were used for quantification of the HN (n = 47). Results: The mean age of the subjects was 39.1 years. The mean levels of eCO were 9.3 ppm, 1.3 ppm, and 1.0 ppm and the mean HN concentrations were 20.9 ng/mg, 2.1 ng/mg, and 0.7 ng/mg in the 3 groups, respectively. There was a significant difference between Group 1 and the other groups according to the levels of eCO and HN concentrations, but the levels of eCO and HN concentrations were similar in Group 2 and Group 3. There was a positive correlation between the levels of eCO and the HN concentrations. The cutoff values of eCO and HN for smokers were 6 ppm and 4 ng/mg, respectively. Conclusion: Although nicotine analysis in some biological samples like hair is specific to TS exposure, these methods are expensive and difficult procedures. Our results suggest that instead of HN analysis, a cheap and easy method like eCO measurement may be used, but further studies with more cases are needed. © TÜBİTAK.Öğe The assessment of the malignant mesothelioma cases and environmental asbestos exposure in Sivas province, Turkey(SPRINGER, 2014) Berk, Serdar; Yalcin, Huseyin; Dogan, Omer Tamer; Epozturk, Kursat; Akkurt, Ibrahim; Seyfikli, ZehraOne of the most significant diseases related to environmental asbestos exposure is malignant mesothelioma (MM). Sivas province is located in the Central Anatolia where asbestos exposure is common. We aimed to study clinical, demographical and epidemiologic features of the patients with MM in Sivas, along with the history of asbestos exposure. In total, 219 patients with MM who were diagnosed in our hospital between 1993 and 2010 were retrospectively analyzed in terms of demographical and clinical features. Rock, soil and house plaster samples were taken from the habitats of those patients and were evaluated with optical microscopy and X-ray diffraction methods. The age of the patients ranged between 18 and 85 years. The male-to-female ratio was 1.4:1. Most of the patients confirmed an asbestos exposure history. The most frequent symptoms of the patients were chest pain (60 %) and dyspnea (50 %). The gap between the start of first symptoms and the diagnosis date was approximately 4 months in average. The plaster materials used in most of the houses were made up of mainly carbonate and silicate minerals and some chrysotile. Ophiolitic units contained fibrous minerals such as serpentine (clino + orthochrysotile) chiefly and pectolite, brucite, hydrotalcite and tremolite/actinolite in smaller amounts. MM is not primarily related to occupational asbestos exposure in our region, and hence, environmental asbestos exposure may be indicted. Yet, single or combined roles and/or interactions of other fibrous and non-fibrous minerals in the etiology of MM are not yet fully understood and remain to be investigated.Öğe 'Biomass Lung': Primitive biomass combustion and lung disease(2002) Bariş, Yusuf Izzettin; Hoskins, John A.; Seyfikli, Zehra; Demir, AhmetDomestic burning of biomass fuel is one of the most important risk factors for the development of respiratory diseases and infant mortality. The fuel which causes the highest level of disease is dung. In the rural areas of developing countries some 80% of households rely on biomass fuels for cooking and often heating as well and so suffer high indoor air pollution. Even when the fire or stove is outside the home those near it are still exposed to the smoke. In areas where the winters are long and cold the problem is aggravated since the fire or stove is indoors for many months of the year. The consequence of biomass burning is a level of morbidity in those exposed to the smoke as well as mortality. The rural areas of Turkey are among many in the world where biomass is the major fuel source. In this case report 8 patients from rural areas, particularly Anatolia, who used biomass are presented. Many of these are non-smoking, female patients who have respiratory complaints and a clinical picture of the chronic lung diseases which would have been expected if they had been heavy smokers. Typically patients cook on the traditional 'tandir' stove using dung and crop residues as the fuel. Ventilation systems are poor and they are exposed to a high level of smoke pollution leading to cough and dyspnoea. Anthracosis is a common outcome of this level of exposure and several of the patients developed lung tumours. The findings from clinical examination of 8 of these patients (2 M, 6 F) are presented together with their outcome where known. Copyright © 2003 S. Karger AG, Basel.Öğe Clinical characteristics, treatment and survival outcomes in malignant mesothelioma(EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2012) Berk, Serdar; Dogan, Omer Tamer; Kilickap, Saadettin; Epozturk, Kursat; Akkurt, Ibrahim; Seyfikli, Zehra…Öğe Clinical Characteristics, Treatment and Survival Outcomes in Malignant Mesothelioma: Eighteen Years' Experience in Turkey(ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2012) Berk, Serdar; Dogan, Omer Tamer; Kilickap, Saadettin; Epozturk, Kursat; Akkurt, Ibrahim; Seyfikli, ZehraBackground: Malignant mesothelioma (MM) is an insidious tumor with poor prognosis, arising from mesothelial surfaces such as pleura, peritoneum and pericardium. We here aimed to evaluate the demographic, clinical, and radiological features of patients with MM followed in our center as well as their survival. Methods: The study included 228 patients (131 male, 97 female) who were followed up in our institution between 1993 and 2010 with the diagnosis of MM. Results: The mean age was 59.1 years in men and 58.7 years in women and the sex ratio was 1.4:1 in favor of males. Environmental asbestos exposure was present in 86% of the patients for a mean duration of 40 +/- 20 years (range: 3-70). Pleural effusion and thoracic/abdominal pain were the most common presenting signs and symptoms (70.2% and 57.8%, respectively). One hundred-thirteen (66%) patients were treated with platinum-based combination chemotherapy (PBCT) plus supportive care (SC) and 67 (34%) patients received SC alone. The median follow-up time was 10.0 months. The median overall survival was significantly improved with PBCT plus SC compared to SC alone (11.4 vs. 5.1 months; p=0.005). The 6, 12, 18, and 24-month survival rates were significantly improved with PBCT plus SC compared to SC alone (72%, 43%, 19%, and 2% vs. 49%, 31%, 11%, and 1%). Conclusion: The survival of patients with MM improved in patients treated with PBCT. The survival advantage continued 12- and 24-month after the initial time of combination chemotherapy.Öğe The evaluation of the relationship between malignant mesothelioma and environmental asbestos exposure in Sivas(EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2012) Berk, Serdar; Yalcin, Huseyin; Epozturk, Kursat; Dogan, Omer Tamer; Seyfikli, Zehra; Akkurt, Ibrahim…Öğe Oxidative status in the lungs associated with tobacco smoke exposure(WALTER DE GRUYTER GMBH, 2011) Doruk, Sibel; Ozyurt, Huseyin; Inonu, Handan; Erkorkmaz, Unal; Saylan, Oguzhan; Seyfikli, ZehraBackground: Oxidative stress has a critical role in inflammatory responce against tobacco smoke (TS). Testing exhaled breath condensate (EBC) samples is one of the methods used for assessment of airway inflammation caused by TS. We aimed to investigate oxidative stress in the lungs associated with TS and to evaluate the effect of this stress with pulmonary function tests (PFTs). Methods: We included 69 subjects as three groups into the study (Group 1; 26 smokers, Group II; 21 passive smokers, Group In; 22 non-smokers without TS exposure). Levels of malondialdehyde (MDA), 8-hydroxydeoxyguanosine (8-OHdG), nitrite/nitrate [index of nitric oxide (NO) production], vitamin C. superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were measured in EBC samples collected using a condenser and PFTs were performed. Results: The levels of MDA, 8-OHdG, SOD and GSH-Px were higher in smokers. NO levels gradually increased from Group I to Group III. MDA levels were lower in Group III than Group II. The levels of vitamin C were similar in all groups. We determined negative correlation between 8-OHdG levels and forced expiratory volume in one second (FEV1), and maximum mean expiratory flow (MMEF), and a positive correlation between SOD levels and FEV1. Conclusions: TS exposure affected the balance between oxidative stress and antioxidant capacity of lungs. Preventing environmental TS exposure might decrease oxidative damage. Increased levels of 8-OHdG and SOD levels could be assessed as an early sign of airway damage.Öğe Relationship between chronic obstructive pulmonary disease and telomerase, agmatine, deubiquitinase and sirtuin in the pathway of aging(Bayrakol Medical Publisher, 2023) Kurucay, Deniz; Ozmen, Zeliha Cansel; Seyfikli, Zehra; Ersan, SerpilAim: Chronic Obstructive Pulmonary Disease (COPD) is a progressive disease that has both chronic bronchitis-related changes in airways and differences of emphysema in the lung parenchyma. Aging is a complex and irreversible process involving cells, tissues, organs and systems resulting from numerous endogenous and exogenous factors. Agmatine, telomerase, deubiquitinase and sirtuin molecules appear during aging process. A better understanding of the role of these molecules in aging process may lead to advancing therapies for COPD and comorbidities.In the present study, it was aimed to investigate whether there was a relationship between COPD, a chronic progressive disease, and agmatine, telomerase, sirtuin and deubiquitinase, which are molecules involved in the aging pathway.Material and Methods: Thirty-five patients with COPD and 35 healthy persons without chronic diseases participated in this study. Serum agmatine levels were measured by a fluorescence detector using a high-performance liquid chromatography method (HPLC). Serum Sirtuin, deuibiquitinase and telomerase levels were performed using the ELISA method.Results: A result of the statical analysis in the terms of the deubiquitinase showed no differences between patients and control groups (p>0.05). In the patient group, sirtuin values were lower than in controls (P<005). Telomerase and agmatine values were higher (P<0.05).Discussion: As a result, the increase in telomerase activity may be to prolong the telomere shortening in COPD patients. The increase in agmatine may also be caused by depression and hypoxia in COPD. Decreased sirtuin in COPD can be explained by the increase in aging and inflammation.Öğe The prevalence of sleep related disorders among the drivers and it's relation with traffic accidents(Turkish Assoc Tuberculosis & Thorax, 2006) Dogan, Omer Tamer; Dal, Ugur; Ozsahin, Sefa Levent; Akkurt, Ibrahim; Seyfikli, ZehraStudies consistently show that patients with sleep related diseases (SRD) have higher accident rates. Polysomnography (PSG) is the gold standard for the diagnosis of SRD. Sleep habits questionnaires are also useful tool for research of the prevalence of SRD on large populations. The aim of this study is to investigate the prevalence of SRD and SRD related traffic accidents on the whole population of professional drivers in Sivas city. A questionnaire that includes questions about drivers' background such as how long they have been driving, if they had any accidents, and if they drive just in Sivas city or inter state. This questionnaire composed of 50 questions about SRD and was asked to drivers answer them face to face. Three hundred forty male drivers participated for this study. Their mean age was 39.5 +/- 9.3 (21-68) years. The mean driving duration was 13.3 +/- 7.9 years. The percentage of drivers who drove in Sivas was 52.1% and 47.9% of the drivers drove inter state. The percentage of drivers who had at least one accident was 36.3%. The prevalence of habitual snoring, insomnia, sleep apnea, nocturnal myoklonus were 41.2%, 39.1%, 32.9%, and 33.6% respectively. The traffic accident Odds ratio was 1.619 for drivers with habitual snoring (95% CI, 1.034 to 2.536, p= 0.02). In conclusion, this study found out that drivers with habituel snoring seems to have tendency (approximately 2-folds) of involving in traffic accidents than drivers who do not have habituel snoring. Polysomnography of candidate drivers with sleep disordered symptoms has to be logical before giving to driving license.
