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    Effect on oxidative stress, hepatic chemical metabolizing parameters, and genotoxic damage of mad honey intake in rats
    (SAGE PUBLICATIONS LTD, 2018) Eraslan, G.; Kanbur, M.; Karabacak, M.; Arslan, K.; Silig, Y.; Soyer Sarica, Z.; Tekeli, M. Y.; Tas, A.
    A total of 66 male Wistar rats were used and six groups (control: 10 animals and experimental: 12 animals) were formed. While a separate control group was established for each study period, mad honey application to the animals in the experimental group was carried out with a single dose (12.5 g kg(-1) body weight (b.w.); acute stage), at a dose of 7.5 g kg(-1) b.w. for 21 days (subacute stage), and at a dose of 5 g kg(-1) b.w. for 60 days (chronic stage). Tissue and blood oxidative stress markers (malondialdehyde (MDA), nitric oxide (NO), 4-hydroxynonenal (HNE), superoxide dismutase, catalase, glutathione (GSH) peroxidase, and glucose-6-phosphate dehydrogenase), hepatic chemical metabolizing parameters in the liver (cytochrome P450 2E1, nicotinamide adenine dinucleotide (NADH)-cytochrome b5 reductase, nicotinamide adenine dinucleotide phosphate (NADPH)-cytochrome c reductase (CYTC), GSH S-transferase (GST), and GSH), and micronucleus and comet test in some samples were examined. Findings from the study showed that single and repeated doses given over the period increased MDA, NO, and HNE levels while decreasing/increasing tissue and blood antioxidant enzyme activities. From hepatic chemical metabolizing parameters, GST activity increased in the subacute and chronic stages and CYTC activity increased in the acute period, whereas GSH level decreased in the subacute stage. Changes in tail and head intensities were found in most of the comet results. Mad honey caused oxidative stresses for each exposure period and made some significant changes on the comet test in certain periods for some samples obtained. In other words, according to the available research results obtained, careless consumption of mad honey for different medical purposes is not appropriate.
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    Effects of the Pringle Manoeuvre on the Healing of Left Colonic Anastomoses in Rats
    (ACTA MEDICAL BELGICA, 2014) Dogan, M.; Sen, M.; Koc, M.; Silig, Y.; Akyol, G.; Karadayi, K.; Turan, M.
    Background : Whether to perform colorectal cancer and liver metastasis resections simultaneously or in separate procedures is controversial. The aim of the present study was to investigate the effect of the Pringle manoeuvre on the healing of left-sided colonic anastomoses in rats. Methods : Sixteen rats were randomly separated into two groups. In Groups 1 and 2, 1 cm of descending colon was resected and a primary anastomosis was performed. In Group 2, an intermittent pedicle clamp (the Pringle manoeuvre) was performed. On postoperative day 5, laparotomy was performed and the bursting pressures of all colon anastomoses were determined. Tissues were sampled for assay of hydroxyproline levels. Cultures of intraperitoneal swabs were also performed. Results : Clostridium was twice as abundant in the Pringle manoeuvre group as in the control group (p <0.05). Anastomosis-bursting pressures and tissue hydroxyproline levels were significantly lower in the Pringle manoeuvre group than in the control group (p <0.05). Conclusions : The Pringle manoeuvre may compromise the viability of colonic anastomoses.
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    Evaluation of novel azomethine compound in genes involved in cell cycle and apoptosis in osteosarcoma cells
    (Wiley, 2024) Agbektas, T.; Pazarci, O.; Tas, A.; Huseynzada, A.; Guliyev, R.; Hasanova, U.; Silig, Y.
    [No abstract available]
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    Primary brain tumor incidence and association with CYP1A1 and CYP2E1 polymorphisms in a Turkish population
    (WILEY, 2006) Pinarbasi, H.; Silig, Y.; Gurelik, M.; Cetinkaya, O.; Bakir, S.
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