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    Anticancer properties of bromelain: State-of-the-art and recent trends
    (Frontiers Media Sa, 2023) Pezzani, Raffaele; Jimenez-Garcia, Manuel; Capo, Xavier; Sonmez Gurer, Eda; Sharopov, Farukh; Rachel, Tchokouaha Yamthe Lauve; Ntieche Woutouoba, David
    Bromelain is a key enzyme found in pineapple (Ananas comosus (L.) Merr.); a proteolytic substance with multiple beneficial effects for human health such as anti-inflammatory, immunomodulatory, antioxidant and anticarcinogenic, traditionally used in many countries for its potential therapeutic value. The aim of this updated and comprehensive review focuses on the potential anticancer benefits of bromelain, analyzing the cytotoxic, apoptotic, necrotic, autophagic, immunomodulating, and anti-inflammatory effects in cancer cells and animal models. Detailed information about Bromelain and its anticancer effects at the cellular, molecular and signaling levels were collected from online databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar. The results of the analyzed studies showed that Bromelain possesses corroborated pharmacological activities, such as anticancer, anti-edema, anti-inflammatory, anti-microbial, anti-coagulant, anti-osteoarthritis, anti-trauma pain, anti-diarrhea, wound repair. Nonetheless, bromelain clinical studies are scarce and still more research is needed to validate the scientific value of this enzyme in human cancer diseases.
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    Investigation of resveratrol and phenolic compounds of ethnomedicinal plant Polygonum cognatum Meissn. collected from Sivas
    (Marmara Univ, 2022) Inal, Ebrar; Ulusoy, Seyma; Algin Yapar, Evren; Sonmez Gurer, Eda; Yalcin, Sule; Kartal, Murat
    Polygonum cognatum Meissn., which is also known as madimak, solucanotu has been used in the Turkish folk medicine for the treatment of various diseases and has also been consumed in the dishes and salads by local people. It has even been the subject of a folk song, sung among the people in Sivas. In this study, it was aimed to examine the resveratrol and phenolic compounds that are valuable for health industry, in leaf and root extracts obtained from P. cognatum, which is widely distrubuted in Sivas. While resveratrol was investigated by using HPLC-PDA, the phenolic compounds were determined by using LC-HRMS. Results of analyses showed that resveratrol could not be detected in both leaf and root extracts, but both root and leaf extracts were quite rich in following phenolic compounds. While chlorogenic acid, hyperoside, rutin, and fumaric acid were the most abundant phenolic compounds detected from the leaf extract, the (+)-catechin, fumaric acid, chlorogenic acid and p-coumaric acid were the most abundant phenolic compounds in the root extract. As a conclusion, P. cognatum with its rich phenolic compounds content of the root and leaf parts are good candidates in terms of using in dietary supplements, health care and cosmetic products.