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Öğe All-in-One Nanohybrids Combining Sonodynamic Photodynamic and Photothermal Therapies(Amer Chemical Soc, 2024) Taydas, Dilsad; Ozler, Muhammed Emre; Ergul, Mustafa; Inan, Zeynep Deniz Sahin; Sozmen, FazliA wide variety of methods are being developed to ultimately defeat cancer; while some of these strategies have shown highly positive results, there are serious obstacles to overcome to completely eradicate this disease. So, it is crucial to construct multifunctional nanostructures possessing intelligent capabilities that can be utilized to treat cancer. A possible strategy for producing these multifunctional nanostructures is to combine various cancer treatment techniques. Based on this point of view, we successfully synthesized multifunctional HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids. The peculiarities of these thermosensitive polymer-modified and protoporphyrin IX (PpIX)-loaded hollow nanohybrids are that they combine photodynamic therapy (PDT), sonodynamic therapy (SDT), and photothermal therapy (PTT) with an intelligent design. As an all-in-one nanohybrids, HCuS@Cu2S@Au-P(NIPAM-co-AAm)-PpIX nanohybrids were employed in the SDT-PDT-PTT combination therapy, which proved to have a synergistic therapeutic effect for in vitro tumor treatments against breast tumors.Öğe BODIPY based self-healing fluorescent gel formation via acylhydrazone linkage(ROYAL SOC CHEMISTRY, 2016) Ozdemir, Tugba; Sozmen, FazliPolymeric BODIPY derivatives with reactive functional groups undergo reversible formation of covalent bonds leading to self-healing properties. Cross-reactivity of acyl-hydrazine and aldehyde moieties forms the basis of dynamic covalent chemistry leading to sol-gel transition in this series of compounds. In addition, thin layers of absorbers show efficient energy transfer indicating a potential in solar concentration.Öğe Determination of biological activity of Tragopogon porrifolius and Polygonum cognatum consumed intensively by people in Sivas(Elsevier, 2020) Eruygur, Nuraniye; Ucar, Esra; Atas, Mehmet; Ergul, Merve; Ergul, Mustafa; Sozmen, FazliObjective: This study was aimed to investigate the in vitro antioxidant, antimicrobial, cytotoxicity, and enzyme inhibition activities of Tragopogon porrifolius and Polygonum cognatum which are naturally grown and consumed intensively by people in Sivas, Turkey. Methods: Plant materials were extracted with aqueous ethanol by maceration method. The components of the extracts were determined using the Gas Chromatography Mass Spectrometry. Antimicrobial, cytotoxic and enzyme inhibition activities of the extracts were investigated by micro dilution, XTT assay and 96-micro-well plate methods, respectively. The antioxidant activity evaluated using the DPPH radical scavenging, thiobarbituric acid and reducing power methods. The total phenol and total flavonoid content was also examined. Results: GC-MS analysis revealed the presence of 31 compounds inP. cognatum extract and 29 compounds in T. porrifolius extract. According to the results, T. porrifolius extract showed high level of antioxidant activity in comparison to P. Cognatum extract. T. porrifolius exhibited higher alpha-glucosidase inhibitory activity, and both extract showed strong alpha-amylase inhibition activity compared to reference drug acarbose. T. porrifolius and P. cognatum ethanolic extracts exhibited antimicrobial activity in the concentration range of 0.039-2.5 mg/ml. Both extracts also exhibited significant anticancer effect on MDA-MB-231 breast cancer cells. The IC50 values of T. porrifolius and P. cognatum extracts in MDA-MB-231 cells were determined as 0.0625 mg/mL and 0.053 mg/mL, respectively. Conclusion: Our findings demonstrated that T. porrifolius and P. cognatum ethanolic extracts have promising effect on antioxidant, antimicrobial and cytotoxic activity as well as enzyme inhibition activity, and hence further studies required to identify specific compounds responsible for these activities.Öğe Determination of inhibitory activities of enzymes, related to Alzheimer's disease and diabetes mellitus of plane tree (Platanus orientalis L.) extracts and their antioxidant, antimicrobial and anticancer activities(C M B ASSOC, 2018) Ucar, Esra; Eruygur, Nuraniye; Atas, Mehmet; Ergul, Merve; Ergul, Mustafa; Sozmen, FazliPlane tree (Platanus orientalis L.) leaves have been employed for centuries in various countries due to their pharmacological value. Therefore, determination of the biological activity of the leaves is of interest. The aim of the study was to evaluate the inhibitory effects against Alzheimer's disease-related enzymes Acetylcholinesterase (AChE) and Butyrylcholinesterase (BuChE), diabetes mellitus related enzymes alpha-glucosidase and alpha-amylase. The antioxidant, anticancer, and antimicrobial activities of the leaves were also studied. According to the results, both water and methanol extracts of P. orientalis demonstrated more alpha-glucosidase and alpha-amylase inhibition activity than the antidiabetic drug-acarbose at the same concentration level. In addition, extracts showed good inhibition activity against AChE and BuChE. Significant results were obtained regarding antioxidant, anticancer, and antimicrobial activities. These results are very promising especially for the improvement of pharmaceutical formulations to treat various diseases such as age-related diseases, cancer, diabetes etc. and it is necessary to conduct further experiments.Öğe Evaluation of Various Biological Activities of Endemic Sideritis libanotica Extracts(Horticulture and Forestry Society from Transylvania, 2019) Atas, Mehmet; Eruygur, Nuraniye; Sozmen, Fazli; Ergul, Mustafa; Ergul, Merve; Akpulat, Huseyin Askin; Ucar, EsraIn recent years, using of plants to develop combine therapies for treatment of certain diseases such as cancer, Alzheimer's disease, and diabetes mellitus is extremely plausible approach. Perhaps, the definitive treatment of some of these diseases is hidden in the complex content of a plant in nature. Thus, in the present study, we decided to determine the biological activities of methanol and water extracts of the endemic Sideritis libanotica. To the best of our knowledge, the present study is the first investigation on antioxidant, enzyme inhibitory activity, antimicrobial activity, and in vitro cytotoxicity of S. libanotica. According to results, while the methanol extract shows better anti-cholinesterase, ?-glucosidase, and ?-amylase inhibition activity and cytotoxicity than the water extract, the tyrosinase inhibitory activity of the water extract was found to be better than the methanol extract. This study provides valuable information on how the biological activity of endemic S. libanotica changes in different solvent extractions such as water and methanol. © 2019, Horticulture and Forestry Society from Transylvania. All rights reserved.Öğe Orthogonal Bodipy Trimers as Photosensitizers for Photodynamic Action(AMER CHEMICAL SOC, 2016) Ozdemir, Tugba; Bila, Jose Luis; Sozmen, Fazli; Yildirim, Leyla T.; Akkaya, Engin U.Orthogonally linked BODIPY units shale exceptional intersystem crossing efficiencies. We now report orthogonal BODIPY trimers with strong absorption in the visible region and high singlet oxygen generation capability. The X-ray diffraction structure confirms that the two peripheral BODIPY units are at a perpendicular angle to the core structure.Öğe Self immolative dioxetane based chemiluminescent probe for H2O2 detection(ELSEVIER SCIENCE SA, 2017) Seven, Ozlem; Sozmen, Fazli; Turan, Ilke SimsekChemiluminescent detection of H2O2 has been achieved by using self immolative dioxetane based probe which enables the signal amplification via disassembly of two chemiluminogenic modules at the same time in response to single analyte. Upon treatment of the probe with H2O2, boronate ester was deprotected subsequently to trigger the decomposition of 1,2-dioxetane ring via CIEEL mechanism which results in light emission as a selective sign of H2O2. (C) 2016 Elsevier B.V. All rights reserved.Öğe Two-Photon Absorption Response of Functionalized BODIPY Dyes in Near-IR Region by Tuning Conjugation Length and Meso-Substituents(Amer Chemical Soc, 2023) Yildiz, Elif Akhuseyin; Unlu, Bekir Asilcan; Karatay, Ahmet; Bozkurt, Yasemin; Ozler, Muhammed Emre; Sozmen, Fazli; Yabas, EbruBODIPY dyes substituted by phenol or -COOMe unitsat themeso-position (C8) with and without a distyryl group including a methoxymoiety at the -C3 and -C5 positions of the BODIPY have been synthesizedto analyze the photophysical properties. To clarify the ground-stateinteraction, absorption and emission features were investigated inthe THF environment. Extending the & pi;-conjugation with the methoxymoiety at -C3 and -C5 positions of BODIPY leads to a spectral shiftingof the absorption maxima toward red by 120 nm. In addition, attachingthe -COOMe unit at the meso-position of the BODIPY structureincreases nonradiative molecular relaxation as compared to compoundspossessing phenol substituents at the same position. We have investigatedthe effect of phenol and a -COOMe group and & pi;-extendedconjugation length with a methoxy moiety on the properties of two-photonabsorption (TPA) and electron transfer dynamics by performing open-aperture(OA) Z-scan and femtosecond transient absorption spectroscopy measurements,respectively. The synthesized BODIPY compounds with the distyryl groupincluding the methoxy unit show TPA character due to the longer conjugationlength and therefore intramolecular charge transfer ability. Basedon the OA Z-scan experiments upon photoexcitation with 800 nm pulsedlaser light, TPA cross-section values were obtained as 74 and 81 GMfor the compounds possessing phenol and -COOMe units at themeso-position of BODIPY treated by distyryl group with methoxy moieties,respectively. Additionally, optical and electronic properties werecalculated theoretically by using the DFT method.
