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    The Clinical Characteristics and Therapeutic Outcomes of Elderly Patients with Chronic Lymphocytic Leukemia: A Retrospective Multicenter Study
    (AMER SOC HEMATOLOGY, 2014) Tombak, Anil; Tiftik, Naci; Dogu, Mehmet Hilmi; Sari, Ismail; Akay, Meltem Olga; Karagulle, Mustafa; Kaya, Emin; Korkmaz, Serdal; Sencan, Mehmet; Akyol, Gulsah; Kaynar, Leylagul; Comert, Melda; Saydam, Guray; Dal, Sinan Mehmet; Ayyildiz, Orhan M.; Yildirim, Rahsan; Kiki, Ilhami; Kara, Erdal; Esen, Ramazan; Sungur, Mehmet Ali; Erkurt, Mehmet Ali; Altuntas, Fevzi; Unal, Ali; Ilhan, Osman
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    Evaluation of Risk Factors Determining Focal Organ Involvement in Patients Diagnosed with Brucellosis
    (Doc Design Informatics Co Ltd, 2024) cakir-Kiymaz, Yasemin; Sungur, Mehmet Ali
    Objective: Brucellosis is a zoonotic infection that is common worldwide. It is a multisystemic disease in which specific organ involvement can be observed. However, no specific diagnostic tests can be used for early identification or prediction of focal organ involvement. This study aims to determine the risk factors that determine focal organ involvement in brucellosis. Methods: 143 patients who were followed with brucellosis between January and June 2022 were included in the study. The patients were divided into two groups, those with focal organ involvement and those without, and their clinical and laboratory findings were compared. The significance level was accepted as 0.05. Results: The average age of the patients was 45.64 +/- 17.3 years, and 51% (n=73) were women. The most common clinical findings were fatigue (97.2%, n=139), sweating (86.7%, n=124), and myalgia (68.5%, n=98). The most common form brucellosis was subacute brucellosis (52.4%, n=75). The focal organ involvement rate was 32.2% (n=46). The most common focal organ involvements were osteoarticular (27.9%, n=40), haematological (6.3%, n=9) and genitourinary (3.5%, n=5). There was no statistically significant difference between the groups in terms of age (p=0.698) and gender (p=0.374). While sweating was less in patients with focal brucellosis (p=0.010), back pain (p=0.046), hip pain (p <0.001), high ALT (p=0.014), high CRP (p=0.003) and high ESR (p <0.001) was more encountered. Conclusion: High CRP, ESR and ALT levels, anemia, back and hip pain may be parameters that predict focal organ involvement in patients diagnosed with brucellosis.
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    Frequency of Hepatosteatosis and Relationship Between Laboratory Parameters and Hepatosteatosis in Chronic Hepatitis B Patients
    (Galenos Publ House, 2024) Cakir, Yasemin; Sungur, Mehmet Ali; Oz, Murtaza; Buyuktuna, Seyit Ali
    Objectives: Hepatosteatosis is very common worldwide and is defined as the accumulation of lipid droplets in hepatocytes. Hepatosteatosis is often associated with metabolic factors such as obesity, insulin resistance, and hypertriglyceridemia. The relationship between chronic hepatitis B (CHB) and hepatosteatosis remains unknown. We investigated the frequency of hepatosteatosis in patients with CHB and to evaluate the relationship between hepatosteatosis and laboratory parameters. Materials and Methods: We retrospectively studied 262 patients with CHB. Patients were divided into two groups, hepatosteatosis and non-hepatosteatosis, according to liver ultrasonography findings. The groups were compared in terms of demographic characteristics and laboratory parameters. Results: A total of 262 patients with CHB were included. The mean age was 45.1 +/- 15.3 years, 136 (51.8%) of whom were male. Liver biopsy was performed in 86 (32.8%) of the patients, 20 (7.6%) had fibrosis, and 163 (62.2%) had steatosis. Among the patients with steatosis, grade 1 steatosis was observed in 30.9 (81/163), grade 2 in 26 (68/163), and grade 3 in 5.3 (14/163). Hypertension, hepatomegaly, and cirrhosis were correlated with the presence of steatosis. Patients with steatosis were older than those without. Fasting glucose levels, low-density lipoprotein levels, and triglyceride levels of patients with steatosis were higher than those of patients without steatosis. High-density lipoprotein levels were lower in the steatosis group. No correlation has been found with gender, body mass index, hepatitis delta virus co -infection, hepatitis B virus (HBV)-DNA levels, or hepatitis B e antigen status between steatosis. Conclusion: We found that hepatosteatosis is present in a significant proportion of patients with CHB. Although the presence of hepatosteatosis was associated with some metabolic parameters, the relationship between it and HBV parameters was not statistically significant.