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Öğe After the Earthquakes with Epicenter in Kahramanmaraş on February 6, 2023; Crush Syndrome(Sivas Cumhuriyet Üniversitesi, 2024) Aşkın, Muhammed Faruk; Taştemur, Şeyma; Gedikli, Mustafa Asım; Candan, Ferhan; Koc, YenerObjective: One of the vital problems after earthquakes that caused many deaths and injuries is crush syndrome due to traumatic muscle damage. The aim of this study was to determine the clinical course of patients with crush syndrome and identify factors that may be associated with crush syndrome. Methods: After the two earthquakes of 7.7 and 7.6 magnitude affecting 11 provinces with the epicentre in Kahramanmaraş on 6 February 2023, 319 patients over the age of 18 were admitted to our hospital between 6-14 February. 87 of 319 patients received inpatient follow-up and treatment. The age, gender, duration of stay in the rubble, province of residence, operation performed, duration of hospital stay, amount of fluid given in the first 24 hours, amount of urine output in the first 24 hours, body trauma sites, some laboratory parameters at the time of admission and during follow-up were retrospectively evaluated from the hospital records of all 43 patients diagnosed with crush syndrome among the inpatients between 6-28 February. Results: The age of the patients was 39±19.6 years, duration of stay under the cave-in(hours) 22.74±36.32, duration of hospitalization(days) 7.26±5.42, amount of fluid given in the first 24 hours(ml) 4954.18±3142, amount of urine output in the first 24 hours(ml) 2646.42±2262.65, admission creatinine(mg/dl) 1.59±2.25, admission creatine kinase(CK)(U/L) 11716.37±18520. 44.2% of the patients were female, 72.1% came from Kahramanmaraş province, 46.5% underwent surgical intervention, 67.4% had an admission CK above 1000 u/l, 14% received hemodialysis treatment and 51.2% had a duration of hospitalization longer than 21 days. The effect of other parameters on the duration of hospitalization and the time to reach the reference range of CK and correlation with laboratory parameters were analysed. Conclusion: As a result, it is thought that the parameters affecting the time to reach the CK reference range and the duration of hospitalization can be used to calculate and reduce the duration of hospitalization in prospective crush syndrome cases.Öğe Anticancer activity of sinapic acid by inducing apoptosis in HT-29 human colon cancer cell line(28.04.2023) Taştemur, Şeyma; Hacısüleyman, Levent; Karataş, Özhan; Yulak Fatih; Ataseven HilmiColorectal cancer is the third most lethal and fourth most commonly diagnosed cancer worldwide. Sinapic acid, a derivative of hydroxycinnamic acid, is a promising phytochemical exhibiting numerous pharmacological activities in various systems. It is a substantial chain-breaking antioxidant that operates as a radical scavenger. The aim of this research was to investigate the antiproliferative effect of sinapic acid on the HT-29 cell line besides the mechanisms underlying this activity. The effect of sinapic acid on the viability of HT-29 cell line was investigated using XTT assay. The levels of BCL-2, cleaved caspase 3, BAX, cleaved PARP, and 8-oxo-dG were measured using ELISA. Gamma-H2AX and cytochrome c expressions were assessed semiquantitatively using immunofluorescence staining. Sinapic acid at 200 µm and higher doses produced a significant antiproliferative effect on HT-29 cells. The IC50 value was found to be 317.5 µm for 24 h. Sinapic acid (317.5 µm) significantly elevated cleaved caspase 3, BAX, cleaved PARP, and 8-oxo-dG levels. The levels of gamma-H2AX foci are significantly higher, while the levels of cytochrome c are lower in sinapic acid-treated HT-29 cells. These results indicate that sinapic acid has antiproliferative, apoptotic, and genotoxic effects on colon cancer cells.Öğe Lenalidomidin tek başına uygulanması ve verapamil ile kombinasyonunun myelom hücre hattı üzerine olan sitotoksik etkilerinin in vitro karşılaştırılması(Cumhuriyet Üniversitesi, 2019) Taştemur, Şeyma; Şencan, MehmetMultiple myelom (MM) plazma hücrelerinin monoklonal çoğalması ile karakterize kötü huylu hematolojik bir hastalıktır. Plazma hücrelerinden M proteini olarak tanımlanan monoklonal immunoglobulin salınmaktadır. MM hematolojik malignitelerin %10-15'ini oluşturmaktadır. Hastalığın seyrinde böbrek hasarı, hiperkalsemi, anemi, kemik hastalığı, kronik yorgunluk, kilo kaybı gibi semptom ve bulgular izlenmektedir. Tedavide yeni ajanlarla yüksek doz kemoterapi ve Otolog Kök Hücre Nakli (OKHN) uygulanabilmektedir. Bununla birlikte MM, bu tedavi seçeneklerine rağmen çaresiz kalınmış bir malignitedir. MM tedavisindeki başarısızlığın sebeplerinden biri de kemoterapötik ilaçlara karşı gelişen dirençtir. İlaç direncini ortadan kaldırmak için kemosensitizer ajanlarla kombinasyonlar çeşitli çalışmalarda bir süredir denenmektedir. Bu amaçla kullanılan kemosensitizerlerden biri de P-glikoproteini (P-gp) baskılayan Verapamil'dir. Çalışmamızda bir immünmodülatuvar ajan olan Lenalidomid tek başına ve Verapamil ile kombine edilerek sitotoksik etkileri karşılaştırılmıştır. Çalışmada U266 multiple myelom hücre hattı kullanılmıştır. 0,001 µM, 0,01 µM, 0,1 µM, 1 µM, 10 µM, 50 µM, 100 µM konsantrasyonlarında tek başına lenalidomid ve yine bu konsantrasyonlarda lenalidomide eklenen 2,5 µg/mL verapamille kombinasyonu olası sitotoksik özellikleri açısından karşılaştırılmıştır. Hücre canlılığı XTT testi ile ölçülmüştür. Lenalidomidin verapamil ile kombine edilmesiyle IC50 değerinde istatistiki olarak anlamlı düşüş sağlanmıştır. Çalışmamız, verapamil ile kombine edildiğinde lenalidomidin sitotoksik etksinin arttığını ortaya konmuştur.Öğe Quercetin in the treatment and prevention of COVID-19(Sivas Cumhuriyet University, 2021) Taştemur, Şeyma; Ataseven, HilmiCoronavirus Disease-19 ( COVID-19) is a disease that started at the end of 2019 and continues to affect all the world as a pandemic. There is no definitive cure for COVID-19 yet. The disease is characterized by excessive immune activity, inflammation and coagulopathy. Many agents have been tried for treatment and prevention. Flavonoids are valuable natural food components with antioxidant, anti-inflammatory and anticoagulant properties. Quercetin, the best known flavonoid, is one of the most studied and beneficial one. Quercetin, which has been shown to be effective in many viral diseases, is mainly used in diseases such as cardiovascular disease and diabetes, which are associated with chronic inflammation. it is an important candidate for the treatment and prophylaxis of COVID-19, thanks to its powerful anti-inflammatory, antioxidant and immune-modulating effects.
