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Öğe Association between homocysteine level and intima-media thickness in patients with first ischemic stroke(UNIVERSITATSVERLAG ULM GMBH, 2005) Tas, Aysenur; Tas, Fikret; Candan, Ferda; Topaktas, SuatObjective - Elevated plasma homocysteine may be a causal risk factor for atherosclerosis but this remains controversial. We evaluated the relationship between intima-media thickness of carotid arteries and plasma level of homocysteine in first ischemic stroke patients. Methods and Results - In the patient group, 175 patients with ischemic stroke (89 men and 86 women; mean age 61.2years [SD 6.83]) and in the control group, 110 healthy subjects without ischemic stroke with healthy subjects (58 men and 52 women; mean age 59.8 years [SD 8.15]) were studied. There was not a statistical difference between two groups regarding age, sex, and conventional vascular risk factors between two groups. Logistic regression analysis was carried out by use of a backward selection strategy with continuous variables (age, homocysteine,folate) and categorical variables (hypertension, diabetes mellitus, hypercholesterolemia, history of previous vascular events and smoking) as independent variables and ischemic stroke as the dependent variable. Important independent risk factors for IMT were hypertension (OR 1.08; 95% Cl 1.03 to 1.13, p= 0.001), homocysteine level (OR 12.1; 95% Cl 2.8 to 55, p= 0.002), hypercholesterolemia (OR 2.26; 95% Cl 1.35 to 3.81, p= 0.002), diabetes mellitus (OR 8.01, 95% Cl 2.1 to 28.2, p=0.003), previous vascular events (OR 2.0 1; 95 % Cl 1.22 to 3.31, p=0.005), current smoker (OR 2.11, 95% Cl 1.01 to 3.74, p=0.03), serum folate (OR 7.06; 95%Cl 7.0 to 7.8 1, p=0.002). Conclusions - Finally, increased plasma homocysteine level was an independent risk factor for intima media thickness in first ischemic stroke. So, we think that further comprehensive and long-term studies necessary on this subject.Öğe Cerebral hemiatrophy (Dyke-Davidoff-Masson syndrome) in childhood: Clinicoradiological analysis of 19 cases(BLACKWELL PUBLISHING, 2007) Atalar, Mehmet H.; Icagasioglu, Dilara; Tas, FikretBackground: The purpose of this study was to emphasize the clinical and imaging findings of 19 child cases of cerebral hemiatrophy. Methods:A total of 11 male and eight female patients underwent assessment with computed tomography and magnetic resonance imaging. The patients ranged from 1 to 17 years in age. The evaluated parameters were: location of the lesions, midline structural shift effect, ipsilateral calvarial and parenchymal changes. Results:Left cerebral hemiatrophy was seen in 14 of the cases while right cerebral hemiatrophy was observed in five cases. Unilateral calvarial thickening was seen in 11 cases, hyperpneumatization of paranasal sinuses in five, and hypoplasia of the middle frontal cranial fossa in three patients. Cerebral peduncle atrophy was noted in seven cases. In total, 11 patients had thalamic atrophy and lentiform nucleus hypoplasia. In one case, cerebral hemiatrophy was associated with ipsilateral large schizencephalic cleft and absence of the septum pellucidum, whereas in another case, there was diffuse cerebellar atrophy associated with cerebral hemiatrophy. Conclusions: Computed tomography and, in particular, magnetic resonance imaging are the procedures of choice with respect to assessment of the etiology and extent of cerebral parenchymal involvement in cerebral hemiatrophy.Öğe Comparison of nasal volume changes during rapid maxillary expansion using acoustic rhinometry and computed tomography(OXFORD UNIV PRESS, 2007) Doruk, Cenk; Soekuecue, Oral; Bicakci, A. Altug; Yilmaz, Ugur; Tas, FikretThe purpose of this study was to compare nasal volume changes using acoustic rhinometry (AR) and computed tomography (CT). The subjects were 10 children (6 girls and 4 boys, with an age range of 12-14 years) who required rapid maxillary expansion (RME) on the basis of their individual malocclusion. All patients were found to have normal nasal cavities following anterior rhinoscopic examination. AR and CT were undertaken at the start of treatment (t(1)) and 6 months after expansion (t(2)). Volume changes due to expansion were evaluated using Wilcoxon's test, and the correlation between the two methods was assessed with correlation analyses. Both methods demonstrated that nasal volume significantly increased following the use of RME (P < 0.05). Correlation analyses showed no difference in volume (P > 0.05) using either of the two methods.Öğe Evaluation of the effects of serum bilirubin levels on intimal medial hyperplasia of carotis vessels(Aves, 2005) Demirel, Yeltekin; Tas, Aysenur; Tas, Fikret; Bolayir, Ertugrul; Topaktas, SuatPurpose: To investigate whether there is an independent effect of serum total bilirubin level on carotid atherosclerosis. Material and Metods: A total number of 145 subjects was used in this case-control type study. While 75 of the subjects had intimal medial hyperplasia in their carotid arteries, 70 of subjects served as the control group who had the same risk factors without intimal medial hyperplasia. Intimal medial hyperplasia was used as a dependent variable whereas hypertension, diabetes, high cholesterol levels, smoking and serum bilirubin levels were used as independent variables. Results: There were no differences between groups when age and sex were compared. Low total bilirubin level was found to be a risk factor for intimal medial hyperplasia as a result of logistic regression analysis [OR: 1.57, confidential limit 95% (1.16-1.93)]. On the other hand, hypertension (OR: 0.28, CI 95 %) and, hypercholesterolemia (OR: 0.31, CI 95 %) were found to be risk factors for intimal medial hyperplasia. Diabetes (OR: 1.38, CI 95 %) and smoking (OR: 0.90, CI 95 %) were not found as risk factors for intimal medial hyperplasia. Conclusion: Low serum total bilirubin level could be suggested as a risk factor for carotid intimal medial hyperplasia.Öğe Thoracic Computed Tomography Findings in Malignant Mesothelioma(KOWSAR PUBL, 2012) Dogan, Omer Tamer; Salk, Ismail; Tas, Fikret; Epozturk, Kursat; Gumus, Cesur; Akkurt, Ibrahim; Ozsahin, Sefa LeventBackground: Malignant pleural mesothelioma (MPM) is an uncommon neoplasm. MPM occurs more frequently in patients born or living in certain villages of Turkey. Objectives: We aimed to review radiological findings of MPM. Patients and Methods: We reviewed the CT findings in 219 biopsy-proven MPM patients admitted to our clinic between 1993 and 2008. Results: The most common CT findings included pleural thickening (n = 197, 90%) classified as diffuse (n = 138, 63%), nodular (n = 49, 22%) and mass-type (n = 16, 7%). Pleural effusion was found in 173 patients (79%), involvement of the interlobar fissures in 159 (73%), mediastinal pleural involvement in 170 (78%), volume contraction in 142 (65%), mediastinal shift in 102 (47%) and mediastinal lymphadenopathy in 54 (25%). Conclusion: MPM may present with diverse radiological features. Pleural thickening and pleural effusion were the most frequent radiological findings. Thoracic CT scans might be assessed more cautiously in patients with environmental exposure to asbestos.
