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    Correlation Between Serum Glucose/Potassium Ratio and The Severity of Mushroom Poisoning at The Time of Admission to The Emergency Departments
    (Sivas Cumhuriyet University, 2022) Tekin, Yusuf; Demirtaş, Erdal; Korkmaz, İlhan; Demirel, Yeltekin; Tekin, Gülaçan; Nur, Naim
    Exposure to wild mushrooms can lead to serious toxicity and death. It is accepted that patients who ingest potentially lethal mushrooms typically develop toxicity signs after six hours. However, clinical manifestations of poisoning that occur less than six hours after ingestion do not exclude the potential for life-threatening toxicity, especially when more than one type of mushroom has been eaten. Whereas there are not any clinical parameters that help to establish the severity of mushroom poisoning. In this study, we aimed to determine the relationship of serum glucose/potassium ratio and the clinical severity of mushroom poisoning cases.This is a retrospective study which includes the mushroom poisoning 510 cases between the years 2007 - 2018. Data consisted of age, gender, clinical history of mushroom poisoning including time from consumption to first symptoms, date of presentation, discharge time and laboratory results including complete blood cell count, biochemistry tests for liver and renal function, and coagulation profile. Patients included in this study were classified as mild-moderate and severe mushroom poisoning groups according to laboratory and clinical characteristics. Glucose, BUN, Creatinine, ALT, AST mean values and glucose/potassium ratio were significantly higher in the clinically severe group patients (p=0.008, p=0.01, p=0.039, p=0.037, p=0.046 and p=0.036 respectively). The sensitivity, specificity and area under curve for glucose/potassium ratio were as follows; 0.68, 0.57 (AUC %95CI) was 0.0647. Glucose/potassium ratio can predict the severity in mushroom poisonings according to our results which can helpful by management in mushroom poisonings as a laboratory result.
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    Increased Circulating Fetuin-A Levels in Patients with Atrial Fibrillation
    (Sociedade Brasileira de Cardiologia, 2024) Tekin, Gülaçan; Tekin, Yusuf Kenan; Aydın, Hüseyin; Nur, Naim
    Background: Biomarkers related to the pathogenesis of atrial fibrillation (AF) have attracted the attention of experts. One of these recently studied biomarkers is Fetuin-A. Objectives: This study aimed to evaluate the relationship between serum Fetuin-A levels and AF. Methods: This study used the convenience sampling method, based on inclusion criteria and consent to participate in the study. The Shapiro-Wilk test was used to confirm the normal distribution of all continuous variables. Categorical variables were presented using absolute and relative frequencies. Both groups (48 patients with AF and 47 controls) were compared in terms of biochemical, hematological, and echocardiographic findings and Fetuin-A. the Chi-square or Fisher's exact test were used to compare groups concerning categorical variables. Continuous variables were compared using the independent samples t-test. P<0.05 was considered statistically significant. Results: Serum Fetuin-A values increased in AF patients when compared to the controls (544±49 ?g/mL versus 484±46 ?g/mL, p=0.001). Moreover, Fetuin-A level was independently associated with AF — AOR = 0.978, 95%; confidence interval (CI) 0.969-988, p < 0.001. The cut-off values in Fetuin-A levels in patients with AF were >511.80 ?g/mL with a sensitivity of 75% and a specificity of 73% — area under the curve (AUC) = 0.804, 95% CI = 0.715-0.892. Conclusions: According to this study, there was a relationship between serum Fetuin-A levels and AF, regardless of conventional cardiovascular risk factors. Therefore, Fetuin-A may play a role in the pathophysiology of AF. Prospectively designed cohort studies are necessary to assess whether or not the results can be generalized for other populations. © 2024, Sociedade Brasileira de Cardiologia. All rights reserved.
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    Kalp Yetersizliği Olan Hastalarda Natriüretik Peptid Düzeyleriile Uyku Kalitesi Arasındaki İlişki
    (2020) Kurt, Recep; Şahin, Anıl; Güneş, Hakan; Turgut, Okan Onur; Tekin, Gülaçan; Yılmaz, Mehmet Birhan
    Amaç: Ejeksiyon fraksiyonu azalmış kalp yetersizliği hastalarında uyku kalitesini etkileyen faktörleri araştırmak. Gereç ve Yöntem: Toplam 105 kalp yetersizliği olan hasta (35 kadın, 70 erkek) çalışmaya dahil edildi. Uyku kalitesi son 1 aylık uyku kalitesi ile ilgili olan Pittsburgh uyku kalitesi indeksi ile değerlendirildi. Global Pittsburgh uyku kalitesi indeksi skoru >5 olan hastalar (76 hasta, Grup II) kötü uyku grubu ve ?5 olan hastalar (29 hasta, Grup I) değerine sahip hasta iyi uyku grubu olarak kabul edildi.Bulgular: Pittsburgh uyku kalitesi indeksi skorları yaş, B?tipi natriüretik peptid, kreatinin, kan üre azotu, sistolik pulmoner arter basıncı, sol ventrikül diyastolik sonu çap, sol atriyal çap ile pozitif korelasyon gösterirken sol ventrikül ejeksiyon fraksiyonu, vücut kitle indeksi ile negatif korelasyon gösterdi. Çok aşamalı lojistik regresyon modelinde ileriye doğru aşamalı regresyon kullanılarak; B?tipi natriüretik peptid, seviyesi (OR = 1,001,% 95 GA: 1,000?1,001 p=0,001), kronik böbrek hastalığı varlığı (OR=19.739,%95 GA: 2.436?159.957, p=0,005) ve daha ileri New York Kalp Cemiyeti sınıfının (OR=23.494, %95 GA: 4.917?112.266 p<0,001) kötü uyku kalitesinin varlığı ile bağımsız olarak ilişkili olduğu sonucuna varılmıştır. Sonuç: Kalp yetersizliği hastalarında kötü uyku kalitesi yaygındır. Yüksek B?tipi natriüretik peptid, seviyeleri, ileri New York Kalp Cemiyeti sınıfları ve kronik böbrek hastalığı varlığı kalp yetersizliği hastalarında kötü uyku kalitesinin bağımsız öngördürücüleri olarak saptanmıştır.