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Öğe A RARE CAUSE OF ACUTE ABDOMINAL PAIN: THE OMENTAL TORSION(Emergency Medicine Physicians Assoc Turkey, 2019) Cankorkmaz, Levent; Ozer, Hatice; Tekin, Yusuf KenanIntroduction: Omental torsion represents the rotation of the omentum on its long axis. It is a rare cause of acute abdominal pain and can mimic clinically many diseases. In this case report, a boy with omental torsion which was detected during laparotomy. Case report: We report a case of primary torsion in a nine-year-old boy who presented with abdominal pain on the right lower abdominal area. The abdominal pain was initially localized to right lower quadrant. Physical examination which revealed tenderness in the right lower quadrant. The patient did not have rebound tenderness. Ultrasonography findings were normal except minimal free fluid in abdomen. The patient had undergone laparotomy. Rotation of greater omentum was seen during operation. Appendectomy and partial omentectomy was performed. Conclusion: Typical symptom of acute appendicitis begin as periumbilical or epigastric pain migrating to the right lower quadrant of the abdomen. This pain migration is the most discriminating feature of the patient's history. Primary omental torsion should be kept in mind as an unusual cause of acute abdominal pain. Especially, if the patient's abdominal pain initial location right lower quadrant.Öğe An Evaluation of the Different Serum Markers Associated with Mortality in Crimean-Congo Hemorrhagic Fever(Rambam Health Care Campus, 2020) Tekin, Yusuf Kenan; Engin, AynurBackground: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease with a high mortality rate. Although CCHF has been widely investigated over the past decade, a review of the literature indicated no data on the prognostic capacity of the mean platelet volume-to-platelet count ratio (MPVPCR) and the red cell distribution width-to-platelet count ratio (RDWPCR) for the systemic inflammatory response in patients with CCHF. This study aimed to evaluate the prognostic ability of MPVPCR and RDWPCR on mortality in patients with CCHF. Methods: A total of 807 patients that were admitted to the Cumhuriyet University Hospital's Emergency Department from January 2010 to December 2018 were involved. The RDWPCR and MPVPCR were separately calculated via absolute blood red cell and platelet counts at the time of admission. Before performing receiver-operating characteristic (ROC) curve analysis to define the optimum cut-off values of MPVPCR and RDWPCR stepwise logistic regression analysis was used to determine the predictive factors related to mortality in CCHF patients. Results: Values of both MPVPCR and RDWPCR were significantly lower in survivors than in non-survivors (MPVPCR: 0.20 +/- 0.23 versus 0.55 +/- 0.55, P<0.001; RDWPCR: 0.27 +/- 0.32 versus 0.77 +/- 0.77, P<0.001, respectively). The MPVPCR (odds ratio [OR], 5.95; P=0.048) was an independent predictor for the prognosis of mortality in CCHF patients. The area under the curve in the ROC curve analysis for MPVPCR was 0.876 with a cut-off of 0.21 (sensitivity 87%, specificity 76%). Conclusion: At the time of admission, MPVPCR might be a useful predictor of mortality in patients with CCHF.Öğe Apoptosis biomarkers (Apaf-1, sFa s, sFa s-L, and caspase-9), albumin, and fetuin-a levels in pulmonary thromboembolic patients(Via Medica, 2020) Aydin, Hüseyin; Tekin, Yusuf Kenan; Korkmaz, Ilhan; Eker, Zeynep; Demirtaş, ErdalINTRODUCTION: Pulmonary thromboembolism (PE) is the third most common medical emergency with mortality due to ischemia and reperfusion lung injury. Lung ischaemia-reperfusion injury. Lung reperfusion damage is believed to cause cellular damage and apoptosis. The aim of the present study was to evaluate the levels of fetuin-A, albumin, and apoptosis biomarkers (Apaf-1, sFas, and sFasL) among pulmonary thromboembolic patients. MATERIAL AND METHODS: Blood samples were collected from 45 volunteer patients and 40 healthy control volunteers. Human apoptosis biomarkers (Apaf-1, sFas, sFasL, and caspase-9) and fetuin-A values were measured by ELISA device. Student's t-test or Mann-Whitney U test were used for continuous variables, and categorical variables were compared with the chi-square test to assess the significance of intergroup differences. The mean values of apoptosis biomarkers and acute phase reactants between dead and survival patients were also compared. RESULTS: While the apoptosis mean values of Apaf-1, sFas, sFasL, and caspase-9 for the control group were 0.12 ± 0.01, 332.1 ± 28.0, 130.4 ± 34.6, and 74.3 ± 2.6, for the patient group they were 0.14 ± 0.02, 509.1 ± 67.6, 139.9 ± 23.7, and 79.4 ± 2.8, respectively. The group differences were significant for all the biomarkers (p = 0.01, p = 0.001, p = 0.19, and p = 0.01, respectively). The negative acute phase fetuin-A and albumin levels decreased significantly in the patient groups (p = 0.01 and p = 0.01, respectively). CONCLUSIONS: Intrinsic and extrinsic apoptosis pathways are stimulated during pulmonary embolism, and negative acute phase reactants are decreased. There was a correlation with the mortality and Apaf-1, sFas, caspase-9, fetuin, and albumin levels. Copyright © 2020 Via Medica.Öğe Are neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios associated with mortality in pediatric trauma patients? A retrospective study(Rambam Health Care Campus, 2019) Tekin, Yusuf KenanBackground: There are very limited data on the prognostic capacity of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for the systemic inflammatory response in pediatric trauma (PT) patients. The purpose of this study was to evaluate the prognostic ability of NLR and PLR on mortality in pediatric trauma patients. Methods: This study looked at 358 PT patients who were admitted to the Cumhuriyet University Hospital’s Emergency Department between January 2010 and June 2018. The NLR and PLR were calculated by dividing the blood neutrophil count and blood platelet count, respectively, by the lymphocyte count, at the time of admission. After performing a stepwise logistic regression analysis to determine the predictive factors on the mortality risk of post-traumatic systemic inflammatory response syndrome (SIRS), receiver operating characteristic (ROC) curve analysis was used to define the optimum cut-off values of the NLR and the PLR parameters for survival. Results: The NLR, and PLR values were significantly higher in survivors than in non-survivors (NLR, 6.2±5.7 versus 2.6±2.5, P<0.001; PLR, 145.3±85.0 versus 46.2±25.2, P<0.001). The NLR (odds ratio [OR], 3.21; P=0.048), PLR (OR, 0.90; P=0.032), blood glucose (OR, 1.02; P=0.024), and Injury Severity Score (ISS) (OR, 1.28; P=0.011) were independent predictors of the mortality risk in PT patients. The area under the curve in the ROC curve analysis was 0.764 with a cut-off of 2.77 (sensitivity 70%, specificity 77%) for the NLR; and 0.928 with a cut-off of 61.83 (sensitivity 90%, specificity 85%) for the PLR. Conclusion: Acquiring the NLR and PLR at the time of admission could be a useful predictor for mortality in PT patients. © 2019 Yusuf Kenan Tekin.Öğe Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients(Springer, 2023) Aslan, Elif Sibel; Aydin, Hueseyin; Tekin, Yusuf Kenan; Keles, Sami; White, Kenneth N.; Hekim, NezihBackground Due to the growing evidence of the importance of iron status in immune responses, the biomarkers of iron metabolism are of interest in novel Coronavirus Disease 2019 (COVID-19). The present prospective study was carried out to compare iron status indicated by levels of ferritin with the levels of two novel biomarkers related to iron homeostasis, hephaestin and hypoxia-inducible factors-1 (HIF-1 alpha) in the serum of patients with COVID-19 in comparison with a control group.Methods and results Blood samples from 34 COVID-19 patients and from 43 healthy volunteers were collected and the levels of HEPH and HIF-1 alpha were measured by ELISA and compared with levels of serum ferritin. COVID-19 patients had higher serum levels of ferritin than those levels in control group (P < 0.0001). Conversely levels of HIF-1 alpha and HEPH in the COVID-19 group were significantly lower than those of control group (P < 0.0001 for both). An inverse correlation between hephaestin and ferritin as well as between HIF-1 alpha and ferritin was found among all subjects (P < 0.0001), and among COVID-19 patients, but not to statistical significance.Conclusion Levels of hephaestin and HIF-1 alpha were found to be inversely related levels of ferritin across all participants in the study, and to our knowledge this is the first report of hephaestin and HIF-1 alpha as potential markers of iron status. Further studies are needed to corroborate the findings, utilizing a broader range of markers to monitor inflammatory as well as iron status.Öğe Change of hand flora during the shift in emergency servise staff(2018) Yurtbay, Sefa; Tekin, Yusuf Kenan; Korkmaz, İlhan; Güven, Mutlu Kukul Fatma; Demirtaş, ErdalObjective: We aimed to reveal the change in microorganisms in the hand flora during the working period from hospitalpersonnels in the emergency department of Cumhuriyet University by taking hand cultures before and after the workingperiod.Method: Our study was planned to evaluate the change of the hand flora and pre-shift and post-shift hand cultures from10 physicians, 13 nurses, 10 transport personnel in the emergency department of Cumhuriyet University. Also the microorganisms of air samples from special intervention areas (resuscitation, red area) as well as general use areas wereanalyzed.Results: We compared the washing status between pre (4,%11.1) and post-contact16 (44.4%) hand washing rate. Thevolunteers generally had washed their hands after the contact with the patient and the difference was statistically wassignificantly higher (p <0.05). there wasn’t any difference between the microorganisms samples that were reproduced onthe pre-shift right and left hand samples and post-shift right and left hand. According to the total count of samples takenfrom the left and right hand before shift in terms of the microorganism seen the difference was significiant (t=7,48;p=0,001).Conclusions: Although our participants knew the hand hygiene indications of emergency service workers, their harmonywas found to be low, consistent with many studies in the literature. It has been observed that the habit of using gloves andhand disinfectant was low also. Efficient strategies may be developed; improving institutional healthcare conditions,conducting educations at certain intervals, observing the practitioner and collecting feedback. However, it should be notedthat the most significant issue is that the significance in hand washing is ensured with changes in habits.Öğe Comparison of sulfur transferases in various tissue and mitochondria of rats with type 1 diabetes mellitus induced by streptozotocin(SPRINGER INDIA, 2016) Aydin, Huseyin; Celik, Veysel Kenan; Sari, Ismail; Tekin, Yusuf Kenan; Demirpence, Ozlem; Bakir, SevtapThis study aims to investigate the relationship between sulfurtransferase (STS) activities [rhodanese (TST), mercaptopyruvate sulfurtransferase (MST)] involved in the catalysis of several biochemical reactions including detoxification of cyanide (CN-), restructuring of Fe-S cluster in proteins, and detoxification of oxygen radicals. Rats with type 1 diabetes mellitus induced by streptozotocin (STZ) were anesthetized at 14th day, and liver, lung, kidney, and heart tissues were extracted. All samples were homogenized, and mitochondrial parts were separated. Same processes were performed also in the control group, and TST and MST activities were measured in each part. The homogenate MST (MST (Homo) .) activities of the type 1 diabetes mellitus group were compared with the control group, and a decrease was observed in the lung, liver, and kidney, respectively; at the same time, an increase was seen in the heart tissue. The mitochondrial MST (MST (Mito) .) activities of rats with type 1 diabetes mellitus group were compared with the control group, and a decrease was found in all tissues. The highest decrease in the TST (Mito) . level of rats with type 1 diabetes mellitus was observed in kidney tissue. The TST activities of the type 1 diabetes mellitus group were compared with the control group, and a decrease was observed in the liver, lung, and kidney, respectively; at the same time, an increase was seen in the heart tissue. It is demonstrated in the present study that decreases occur both in enzyme levels of tissue homogenates and in mitochondria, of rats with induced type 1 diabetes mellitus. However, these results were not statistically significant. In the presence of these findings, we think that kidney, liver, lung, and heart tissue can be affected by type 1 diabetes in the long term.Öğe Covid-19 Pandemisinin Acil Servis Yüküne Etkisi(2022) Çelik, Şimşek; Yurtbay, Sefa; Tekin, Yusuf Kenan; Korkmaz, Ilhan; Çelık, PelinGiriş: Pandemi döneminde acil servislere başvuran hasta sayısı ve profilinde değişiklikler olduğu görülmektedir. Bu araştırma, pandemi öncesi ve pandemi dönemindeki acil servise başvuran hasta yükünü incelemek, hastaların demografik özelliklerini ve başvuru şikayetlerini belirlemek amacıyla yapılmıştır. Gereç ve Yöntem: Acil Servise 1 Nisan 2019- 30 Nisan 2019 tarihleri arasında ve 1 Nisan- 30 Nisan 2020 tarihleri arasındaki hasta başvuruları geriye dönük olarak incelenmiştir. Hastaların demografik özellikleri ve acil servise başvuru şikayetleri değerlendirilmiştir. Bulgular: Acil servise başvuran hasta sayısı pandemi öncesi dönemde 36617 iken, pandemi döneminde ise 10907 olmuştur. Pandemi dönemi ve pandemi öncesi dönem karşılaştırıldığında; yeşil alanda takip edilen hasta, travma hastası, toplam yatan hasta, kardiyoloji servisine yatan hasta, nöroloji servisine yatan hasta, göğüs hastalıkları servisine yatan hasta ve ambulans ile acil servise başvuran hasta sayılarında pandemi döneminde önemli düzeyde azalma olduğu belirlenmiştir. Sonuç: Pandemi döneminde, pandemi öncesi döneme göre acil servisdeki toplam hasta sayısı ve alan hasta sayıları (yeşil, sarı) anlamlı oranda düşüş göstermiştir. Bu durum mortalite ve morbiditenin artmasına neden olabilir. Bu nedenle halkın hastaneye yatış gerektiren acil hastalıklar hakkında detaylı bir şekilde bilgilendirilmesi çok önemlidir.Öğe Current Basic Life Support for Senior Dentistry Students Evaluation of Knowledge Levels(Ataturk Universitesi, 2024) Çelik, Şimşek; Tekin, Yusuf KenanObjective: The aim of this study is to evaluate the basic life support knowledge, the self-confidence of applying basic life support, before and after the education of senior dentistry students. Methods: 96 senior dentistry students participated in this study. The basic life support knowledge level assessment was carried out in 2 stages, before and after the training, theoretically and practically with a model. The questionnaire and the application were evaluated over 10 points, and the students' level was determined by dividing the scores into three categories as bad, moderate and good (bad?3, 4?medium?7, 8?good). Results: The rates of correct answers to all questions in the questionnaire and all basic life support applications on the model increased significantly after the training. Theoretical knowledge (questionnaire) scores before the training went from 1.9±1.01 to 9.1±0.75 points after the training. It increased from 0.9±1.27 to 8.9±0.97 points, and these score increases were statistically significant (P<.001). The self-confidence scores of the students about basic life support increased from 2.5±0.85 before the education to 7.0±0.96 points after the education and were found to be statistically significant (P<.001). Conclusion: It is essential that dental students receive regular basic life support training that will develop their knowledge and skills in managing cardiac arrest, an important medical emergency that can occur at any time during their dental career. © 2024, Ataturk Universitesi. All rights reserved.Öğe DETERMINATION OF CHANGES IN VITAMIN D, FOLIC ACID AND VITAMIN B12 LEVELS IN PATIENTS PRESENTING TO THE EMERGENCY DEPARTMENT AFTER SUICIDAL INTERVENTIONS(Sivas Cumhuriyet Üniversitesi, 2023) Gençer, Tansu; Tekin, Yusuf Kenan; Gençer, Samet BarışABSTRACT Introduction: Depression is a psychological and physiological destruction process. In recent years, it has been one of the leading causes of public health problems in our country and in the world. Patients with depressive mood are at a higher risk compared to the normal population in terms of realizing suicidal ideation. Since the first place of application after a suicide attempt is usually the emergency services, the studies carried out in the ED are extremely important in this sense. Methods: Data in the study were analyzed using SPSS Data:23.0 (SPSS Inc., Chicago, Illinois, USA). Continuous variables were expressed as mean ± standard deviation (SD). In the evaluation of the data, the significance test of the difference between the two means (Independent t test) was used when the parametric test assumptions were fulfilled, and the Man Whitney U test was used when the parametric test assumptions were not fulfilled. Results: In our study, we compared the levels of vitamin D, folic acid and vitamin B12 in patients who applied to the emergency department after a suicide attempt with the normal population. Vitamin D and vitamin B12 levels were found to be significantly lower in the patient group compared to the control group. Conclusions: Our current clinical study supports many studies in the literature, with the detection of low levels of vitamin D and vitamin B12 after the examinations of the patient group who came to the emergency room with a depressive episode and the control group.Öğe Eosinophil Cell Count Predicts Mortality in the Intensive Care Unit after Return of Spontaneous Circulation(Rambam Health Care Campus, 2022) Korkmaz, Ilhan; Tekin, Yusuf Kenan; Tekin, Gulacan; Demirtas, Erdal; Yurtbay, Sefa; Nur, NaimBackground: Eosinophils constitute 1%-5% of peripheral blood leukocytes, less in the presence of acute infections (referred to as eosinopenia). Studies indicate that eosinopenia can be used as a prognostic predictor for chronic obstructive pulmonary disease exacerbation, sepsis, or acute myocardial infarction disease. There are only a few studies about predicting mortality in emergency departments and intensive care units (ICUs). Prognostic studies about patients in ICUs are generally carried out using different scoring systems. We aimed to analyze if the eosinophil count can estimate the prognosis among non-traumatic patients who underwent cardiopulmonary resuscitation and were hospitalized in ICU thereafter. Methods: The data were evaluated of 865 non-traumatic adult patients (>18 years of age) who were admitted with cardiopulmonary arrest or developed cardiopulmonary arrest during clinical follow-ups. Admission venous blood sample tests, complete blood count, and biochemical laboratory results were recorded. Arterial blood gas results were also evaluated. The mean results of the recorded laboratory results were compared between the surviving and non-surviving patients groups. Results: There was a significant difference between the two groups in regard to platelet, eosinophil count, pH, PaO2, SaO(2), and HCO3- (P<0.001 for all). In the multiple linear regression analysis, eosinophil counts were found to be an independent factor (odds ratio=0.03, 95% confidence interval 0.33-0.56, P<0.001) associated with the mortality after cardiopulmonary resuscitation. Conclusion: Because admission eosinophil counts can be measured easily, they are inexpensive biomarkers that can be used for predicting the prognosis among the patients who have return of spontaneous circulation and are treated in ICUs.Öğe Evaluation of respiratory function in healthcare workers wearing face masks during the COVID-19 pandemic(W B Saunders Co-Elsevier Inc, 2023) Cebecioglu, Ismail Kivanc; Demirtas, Erdal; Tekin, Yusuf Kenan; Korkmaz, IlhanBackground: The COVID pandemic, which has caused high mortality rates worldwide, has mainly affected the working environment of healthcare workers. Metabolic and respiratory changes occur in healthcare workers working with surgical masks. Objective: Our aim is to identify the metabolic and respiratory problems faced by healthcare personnel working with surgical masks and to produce solutions to minimize them. Methods: The study was conducted among emergency service workers who used surgical masks for at least 8 h in the emergency room between June 2020 and July 2020. Venous blood gas samples were taken from the health personnel participating in the study and their vital signs were checked. Result: A total of 60 healthcare professionals with a mean age of 28.20 +/- 6.30 years were included in the study. The distribution of men and women in the study was balanced with 30 ( 50.0%) men and 30 (50.0%) women. When the first and last vital signs (blood pressure, pulse, saturation) of the health workers participating in the study were examined, no statistically significant differences were found (p > 0.05). While there was no statistically significant difference in the Na, Chlorine, Ca values of meta-bolic indicators (p > 0.05), the first measurements of K (0.017) and Lactate (0.037) values were found to be higher than the last measurements (p > 0.05). The first measurements of the respiratory parameters pH (0.002), pCO2 (0.028), sO2 (0.045) and pO2 (0.048) were lower than the last measurements (p > 0.05). The first measurement value of pCO2 (0.028) was found to be higher than the last (p > 0.05). Conclusions: Regular and long-term use of surgical masks does not harm the body metabolically and respiratorily.(c) 2022 Elsevier Inc. All rights reserved.Öğe Evaluation of the Demographic and Laboratory Data of Patients Diagnosed with Crimean-Congo Hemorrhagic Fever in the Emergency Department and Their Relationship with Morbidity and Mortality(Emergency Medicine Physicians Assoc Turkey, 2021) Soylu, Umit; Demirtas, Erdal; Buyuktuna, Seyit Ali; Korkmaz, Ilhan; Tekin, Yusuf Kenan; Yurtbay, SefaAim: Crimean-Congo hemorrhagic fever (CCHF) is transmitted by infected ticks or through contaminated blood, tissue, and body fluids. Pathological laboratory results, such as thrombocytopenia, leukopenia, and anemia, along with biochemistry and coagulation parameters, can be used for its diagnosis and the determination of its prognosis. Materials and Methods: Data of patients over 17 years of age diagnosed with CCHF between 2013 and 2018 were reviewed retrospectively. The complete blood count, liver-renal enzymes, electrolytes, prothrombin time, activated partial thromboplastin time (aPTT), D-dimer values, fibrinogen values, and international normalized ratio (INR) were recorded and analyzed at admission. Results: Non-survivors had higher levels of alkaline phosphatase, alanine aminotransferase, amylase, aspartate aminotransferase (AST), blood urea nitrogen (BUN), direct bilirubin, gamma-glutamyl transferase, creatinine, potassium, total bilirubin and uric acid (p<0.05), whereas creatine kinase (CK), CK-MB, and calcium levels were lower (p<0.05). Non-survivors had higher levels of basophil, mean corpuscular hemoglobin concentration, mean corpuscular volume, neutrophil, nucleated red blood cells, platelet distribution width, and white blood cells (p<0.05). Conclusion: Evaluation of routine blood parameters of CCHF patients in the emergency room is a useful tool to accelerate recovery in intensive care and prevent delay in patient treatment. Platelet, aPTT, INR, BUN, and AST values are predictors for mortality.Öğe Glutamine-Driven Metabolic Adaptation to COVID-19 Infection(Springer India, 2023) Aydin, Huseyin; Tekin, Yusuf Kenan; Korkmaz, Ilhan; Tekin, Gulacan; Yurtbay, Sefa; Keles, Sami; Hekim, NezihBackground COVID-19 is known to be transmitted by direct contact, droplets or feces/orally. There are many factors which determines the clinical progression of the disease. Aminoacid disturbance in viral disease is shown in many studies. In this study we aimed to evaluate the change of aminoacid metabolism especially the aspartate, glutamine and glycine levels which have been associated with an immune defence effect in viral disease. Methods Blood samples from 35 volunteer patients with COVID-19, concretized diagnosis was made by oropharyngeal from nazofaringeal swab specimens and reverse transcriptase-polymerase chain reaction, and 35 control group were analyzed. The amino acid levels were measured with liquid chromatography-mass spectrometry technology. Two groups were compared by Kolmogorov-Smirnov analysis, Kruskal-Wallis and the Mann-Whitney U. The square test was used to evaluate the tests obtained by counting, and the error level was taken as 0.05. Results The average age of the patient and control group were 48.5 +/- 14.9 and 48.8 +/- 14.6 years respectively. The decrease in aspartate (p = 5.5 x 10(-9)) and glutamine levels (p = 9.0 x 10(-17)) were significiantly in COVID group, whereas Glycine (p = 0.243) increase was not significiant. Conclusions Metabolic pathways, are affected in rapidly dividing cells in viral diseases which are important for immun defence. We determined that aspartate, glutamine and glycine levels in Covid 19 patients were affected by the warburg effect, malate aspartate shuttle, glutaminolysis and pentose phosphate pathway. Enteral or parenteral administration of these plasma amino acid levels will correct the duration and pathophysiology of the patients' stay in hospital and intensive care.Öğe Increased Circulating Fetuin-A Levels in Patients with Atrial Fibrillation(Sociedade Brasileira de Cardiologia, 2024) Tekin, Gülaçan; Tekin, Yusuf Kenan; Aydın, Hüseyin; Nur, NaimBackground: Biomarkers related to the pathogenesis of atrial fibrillation (AF) have attracted the attention of experts. One of these recently studied biomarkers is Fetuin-A. Objectives: This study aimed to evaluate the relationship between serum Fetuin-A levels and AF. Methods: This study used the convenience sampling method, based on inclusion criteria and consent to participate in the study. The Shapiro-Wilk test was used to confirm the normal distribution of all continuous variables. Categorical variables were presented using absolute and relative frequencies. Both groups (48 patients with AF and 47 controls) were compared in terms of biochemical, hematological, and echocardiographic findings and Fetuin-A. the Chi-square or Fisher's exact test were used to compare groups concerning categorical variables. Continuous variables were compared using the independent samples t-test. P<0.05 was considered statistically significant. Results: Serum Fetuin-A values increased in AF patients when compared to the controls (544±49 ?g/mL versus 484±46 ?g/mL, p=0.001). Moreover, Fetuin-A level was independently associated with AF — AOR = 0.978, 95%; confidence interval (CI) 0.969-988, p < 0.001. The cut-off values in Fetuin-A levels in patients with AF were >511.80 ?g/mL with a sensitivity of 75% and a specificity of 73% — area under the curve (AUC) = 0.804, 95% CI = 0.715-0.892. Conclusions: According to this study, there was a relationship between serum Fetuin-A levels and AF, regardless of conventional cardiovascular risk factors. Therefore, Fetuin-A may play a role in the pathophysiology of AF. Prospectively designed cohort studies are necessary to assess whether or not the results can be generalized for other populations. © 2024, Sociedade Brasileira de Cardiologia. All rights reserved.Öğe Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Crimean-Congo Hemorrhagic Fever(2024) Tekin, Yusuf Kenan; Çelik, ŞimşekObjective:This study aimed to determine the relationship of lactate/albumin (L/A) ratio with prognosis and fatality in CCHF patients. Materials and Methods: A total of 260 patients diagnosed with CCHF between January 2019 and December 2022, 36 of whom were deceased and 224 of whom were alive, were retrospectively included in the study. The findings of survivor and non-survivor patients were compared. Results: There was no significant difference between the groups in terms of age and gender. While albumin, glucose and platelet levels were quite low in the patient group who died due to CCHF (pÖğe Mean Platelet Volume-to-Platelet Count Ratio, Mean Platelet Volume-to-Lymphocyte Ratio, and Red Blood Cell Distribution Width-Platelet Count Ratio as Markers of Inflammation in Patients with Ascending Thoracic Aortic Aneurysm(Soc Brasil Cirurgia Cardiovasc, 2020) Tekin, Yusuf Kenan; Tekin, GulacanObjective: Ascending thoracic aortic aneurysm (ATAA), seen in adults, is an important cause of morbidity and mortality. In this study, we aimed to evaluate the levels of mean platelet volume (MPV), mean platelet volume-to-platelet count ratio (MPVPCR), mean platelet volume-to-lymphocyte ratio (MPVLR), and red cell distribution width platelet count ratio (RDWPCR) in patients with thoracic aortic aneurysm. Methods: 105 patients admitted to the emergency department were diagnosed with thoracic aortic aneurysm between January and December 2014, and 100 healthy individuals were involved in this retrospective study. MPV, MPVLR, MPVPCR and RDWPCRs were calculated at the time of admission. Results: Platelet and lymphocyte levels were found to be significantly lower in the patient group when compared to the healthy group (P<0.001, P<0.001, respectively), while MPV, MPVPCR, MPVLR and RDWPCR were found to be significantly higher (P<0.001, P<0.001, P<0.001, and P=0.013, respectively). In the patient group, the high-sensitivity C-reactive protein was significantly higher (P<0.001), and the neutrophil (P=0.062) was also higher. In ROC analysis, MPVPCR had the highest sensitivity (80%) and RDWPCR had the highest specificity (72%). Conclusion: The results for MPV, MPVPCR, MPVLR and RDWPCR can be evaluated as useful parameters in the emergency clinical approach in the evaluation of inflammatory activity in ATAA patients. More extensive studies are required to address the role of these parameters in determining the severity of the disease.Öğe Occlusive coronary artery disease: A diagnosis that must be excluded(W B Saunders Co-Elsevier Inc, 2024) Tekin, Gulacan; Tekin, Yusuf Kenan[Abstract Not Available]Öğe Optic nerve sheath diameter measurements to predict delayed neurological sequelae after carbon monoxide poisoning(Taylor & Francis Ltd, 2024) Tekin, Yusuf KenanObjectives: Delayed neurological sequelae are a major complication of carbon monoxide poisoning. However, today there is still no objective screening tool for predicting delayed neurological sequelae in patients with carbon monoxide poisoning. The present study aimed to assess the usefulness of optic nerve sheath diameter measurements in predicting delayed neurological sequelae after carbon monoxide poisoning. Methods: In this retrospective study, patients with a diagnosis of carbon monoxide poisoning in the emergency department from 2010 to 2021 were included in the study. Right and left optic nerve sheath diameters were calculated based on cranial computed tomography scans, and the presence of delayed neurological sequelae was evaluated. Results: The mean (+/- standard deviation) optic nerve sheath diameter in patients who developed delayed neurological sequelae was statistically significantly greater on both the right and left compared to patients who did not develop delayed neurological sequelae (right; 5.02 +/- 0.06 mm versus 4.89 +/- 0.07 mm, P < 0.001; left; 5.03 +/- 0.09 mm versus 4.85 +/- 0.10 mm, P < 0.001). A multivariate linear regression analysis revealed that carboxyhemoglobin and both right and left optic nerve sheath diameter were the factors associated with the delayed neurological sequelae. Discussion: The present study revealed that optic nerve sheath diameter measurements may be a useful screening tool to predict delayed neurological sequelae after carbon monoxide poisoning. The ability to predict a poor neurological prognosis in carbon monoxide poisoning is important for initiating early rehabilitation interventions and make help future trials. Limitations of this study include that normal optic nerve sheath diameters are not well established, and that not every patient underwent computed tomography. Conclusions: Optic nerve sheath diameters measurements may be a helpful screening tool for predicting delayed neurological sequelae after carbon monoxide poisoning.Öğe Response to the Letter: Mean Platelet Volume and Related Parameters May Not Contribute to the Diagnosis in Patients with Ascending Thoracic Aortic Aneurysm(Soc Brasil Cirurgia Cardiovasc, 2022) Tekin, Yusuf Kenan; Tekin, Gulacan; Korkmaz, Ilhan; Yurtbay, Sefa[Abstract Not Available]
