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Öğe Assessment of Hematological Factors Involved in Development and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss(LIPPINCOTT WILLIAMS & WILKINS, 2016) Durmus, Kasim; Terzi, Hatice; Karatas, Tuba Dogan; Dogan, Mansur; Uysal, Ismail Onder; Sencan, Mehmet; Altuntas, Emine ElifObjective: The aim of this study was to investigate the possible effects of routine hematological parameters on the development and prognosis of idiopathic sudden sensorineural hearing loss in patients applying to our clinic. Study design: A retrospective clinical study. Setting One academic health center from 2008 to 2014. Patients and intervention: One hundred forty patients with sudden hearing loss and 132 healthy controls were included in the present study. Results: Patients having idiopathic sudden sensorineural hearing loss were divided into 2 subgroups based on whether they recovered (complete, partial, and slight recovery) (Group 1; n = 83, 59.3%) or not (Group 2; n = 57, 40.7%) during the follow-up term. Group 1, Group 2, and the controls differed statistically significantly in terms of neutrophil-to-lymphocyte ratio (P = 0.001), platelet-to-lymphocyte ratio (P = 0.001), lymphocytes%(P = 0.001), mean corpuscular hemoglobin (P = 0.019), mean corpuscular hemoglobin concentration (P = 0.015), platelet (P = 0.001), mean platelet volume (P = 0.001), platelet distribution width (P = 0.009), and glucose (P = 0.001). The study groups and the controls did not have any significant difference in terms of other laboratory parameters affecting the prognosis of Idiopathic sudden sensorineural hearing loss. Conclusions: The results the authors obtained showed that laboratory parameters such as lymphocyte, lymphocyte%, platelet, mean platelet volume, platelet distribution width, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration may be indicative for prognosis and treatment success in groups of patients suffering idiopathic sudden sensorineural hearing loss in whose etiology many factors play a role.Öğe The association between therapeutic outcomes and VEGF G-1154A and C-936T gene polymorphisms in patients with glomerulonephritis(INFORMA HEALTHCARE, 2014) Terzi, Hatice; Kayatas, Mansur; Korkmaz, Serdal; Yildiz, Gursel; Candan, FerhanBackground: In this present study, we aimed to investigate the association between therapeutic outcomes and vascular endothelial growth factor (VEGF) G-1154A and C-936T gene polymorphisms in patients with glomerulonephritis. Methods: Thirty-eight patients with glomerulonephritis diagnosed by renal biopsy were included to the study. All patients had proteinuria at least 1 gram (g)/day in urine analysis. At the end of a yearly therapy, patients with proteinuria less than 0.5 g/day were accepted as in complete remission and they were termed as group 1. The patients with proteinuria over 0.5 g/day were accepted as in no remission and they were termed as group 2. Results: The mean age of patients in group 1 and group 2 was 35.88 +/- 13.80 years and 37.30 +/- 13.89 years, respectively. There were nine (50%) male and nine (50%) female patients in group 1. In group 2, seven (35%) male and 13 (65%) female patients were present. Although VEGF G-1154A (GG) gene polymorphism was found in 55% of group 2 patients, and 22.2% of group 1 patients, but the differences did not reach statistical significance. There were no statistical differences between groups in terms of other gene polymorphisms. Namely, we obtained no statistical differences between therapeutic outcomes and gene polymorphisms. Conclusions: There is a significant difference between groups in terms of VEGF G-1154A (GG) gene polymorphism, but the minority of the patient population has led to not to reach statistical significance. So, this gene polymorphism has to be investigated in larger studies.Öğe Bir Üniversite Hastanesinde Çalışan Hemşire ve Ebelerin Kan ve Kan Ürünleri Transfüzyonu Konusundaki Bilgi Düzeylerinin Belirlenmesi(Sivas Cumhuriyet Üniversitesi, 2024) Terzi, Hatice; Sevimligül, Gülgün; Yurtsever, İlkay; Şencan, MehmetAmaç: Kan transfüzyonu, gerçekte bir doku nakli olup, gelişebilecek komplikasyonlar hayati önem arzeder. Bu nedenle transfüzyonu yapacak olan sağlık personellerinin bu konuda eğitimli olması gerekmektedir. Çalışmamızda hastanemizde görevli hemşire ve ebelerin transfüzyon konusunda bilgi düzeyini belirlemeyi amaçladık. Materyal-Metod: Çalışmaya Sivas Cumhuriyet Üniversitesi Tıp Fakültesi Hastanesi’nde görevli 514’ü (%96,3) hemşire, 20 si (%3.7) ebe olmak üzere toplam 534 kişi alınmıştır. Kullanılan anket formu kişisel bilgileri içeren 9, transfüzyon öncesi bilgileri değerlendiren 9, kan transfüzyon süreci ile ilgili 7, kan ve kan ürünleri ile ilgili 6, kan transfüzyon reaksiyonu ile ilgili 3 adet soru içermektedir. Anketten aldıkları puana göre katılımcılar, grup I (0-85) ve grup II (86-100) olmak üzere iki alt gruba ayrıldı. Bulgular: Katılımcıların yaş ortalaması 30.28±7.60 (18-55) yıl idi. Anket sorularından, transfüzyon öncesi hemşirelik sorumluluklarına ilişkin sorulara %93.28, transfüzyon sürecine ait sorulara %95.2 transfüzyon reaksiyonlarını tanımlama ve yönetme ile ilgili sorulara %94.5, kan ve kan ürünleri ile ilgili bilgi düzeylerini değerlendiren sorulara %71.71 oranında doğru cevap alındı. Sonuç: Kan ve kan ürünleri transfüzyonu belli bir bilgi düzeyi gerektiren karmaşık bir süreçtir. Genel olarak hastanemizde görevli hemşire ve ebelerin eğitim durumu, daha önce aldıkları hizmet içi transfüzyon eğitimi, transfüzyon ve reaksiyon tecrübesi ile orantılı olarak iyi bir transfüzyon becerisine sahip olduğunu söyleyebiliriz.Öğe Clinical characteristics, post-treatment assessment and prognostic factors affecting patient survival of patients at 65 years of age or older with hodgkin lymphoma: A retrospective multicenter study from Turkey(A. CARBONE Editore, 2015) Berber, Ilhami; Erkurt, Mehmet Ali; Keklik, Muzaffer; Dogu, Mehmet Hilmi; Terzi, Hatice; Pala, Cigdem; Sari, Hakan IsmailIntroduction: During the last three decades, major advances have been made in the therapy of Hodgkin's lymphoma. However, despite these advances, Hodgkin's lymphoma has a poor prognosis in the elderly. The proportion of Hodgkin's lymphoma patients aged > 60 ranges in the different reports between 15% and 35%. This study aimed to examine clinical characteristics, treatment outcomes and prognostic factors affecting patient survival in Hodgkin's lymphoma patients aged 65 years or older. Material methods: Hodgkin's lymphoma patients at 65 years of age and older managed within last 5 years in a total of 5 centers in Turkey were retrospectively assessed. Results: The median age of a total of 32 patients was 71 (65-83) years. Elderly patients presented more frequently with B symptoms, elevated sedimentation rate, mixed cellularity histologic subtype and comorbid disease. Less frequent were bulky disease, bone marrow involvement, and the application of autologous stem cell transplantation. The nodular lymphocyte predominant subtype and lymphocyte rich subtype were not observed at all. Eastern Cooperative Oncology Group, ferritin, total protein, and histological type were significant predictors affecting survival (p<0.05). Conclusions: Hodgkin's lymphoma is a more fatal disease in 65 years of age or older, when compared to the young population. Tumor biology, older age itself, and other factors related to comorbidity probably contribute to the worse outcome of elderly patients. Further large-scale studies are needed to better investigate the factors that were significant predictors of patient survival.Öğe CLINICAL CHARACTERISTICS, POST-TREATMENT ASSESSMENT AND PROGNOSTIC FACTORS AFFECTING PATIENT SURVIVAL OF PATIENTS AT 65 YEARS OF AGE OR OLDER WITH HODGKIN LYMPHOMA: A RETROSPECTIVE MULTICENTER STUDY FROM TURKEY(CARBONE EDITORE, 2015) Berber, Ilhami; Erkurt, Mehmet Ali; Keklik, Muzaffer; Dogu, Mehmet Hilmi; Terzi, Hatice; Pala, Cigdem; Sari, Hakan Ismail; Sencan, Mehmet; Sivgin, Serdar; Hacioglu, Sibel; Altuntas, Fevzi; Aydogdu, Ismet; Ilhan, OsmanIntroduction: During the last three decades, major advances have been made in the therapy of Hodgkin's lymphoma. However, despite these advances, Hodgkin's lymphoma has a poor prognosis in the elderly. The proportion of Hodgkin's lymphoma patients aged > 60 ranges in the different reports between 15% and 35%. This study aimed to examine clinical characteristics, treatment outcomes and prognostic factors affecting patient survival in Hodgkin's lymphoma patients aged 65 years or older. Material methods: Hodgkin's lymphoma patients at 65 years of age and older managed within last 5 years in a total of 5 centers in Turkey were retrospectively assessed. Results: The median age of a total of 32 patients was 71 (65-83) years. Elderly patients presented more frequently with B symptoms, elevated sedimentation rate, mixed cellularity histologic subtype and comorbid disease. Less frequent were bulky disease, bone marrow involvement, and the application of autologous stem cell transplantation. The nodular lymphocyte predominant subtype and lymphocyte rich subtype were not observed at all. Eastern Cooperative Oncology Group, ferritin, total protein, and histological type were significant predictors affecting survival (p<0.05). Conclusions: Hodgkin's lymphoma is a more fatal disease in 65 years of age or older, when compared to the young population. Tumor biology, older age itself, and other factors related to comorbidity probably contribute to the worse outcome of elderly patients. Further large-scale studies are needed to better investigate the factors that were significant predictors of patient survival.Öğe Determination of Serum Cathepsin G Level in Patients with Multiple Myeloma(2024) Terzi, HaticeMultiple myeloma is a hematological malignancy identified by bone marrow infiltration of clonal plasma cells. It is still not a curable disease under current conditions. Cathepsin G is a serine protease playing a role in inflammation that is present in the azurophilic granules of neutrophils. It is known that there is a relationship between Cathepsin G and chronic inflammatory diseases and tumors. The goal of the study is to define its role in multiple myeloma. In the study, 33 patients newly diagnosed with MM who were never received treatment and 33 control subjects were included. Basic laboratory parameters and Cathepsin G levels were examined both in the myeloma patient group and control group. While the serum CathG level in the control group is 22.84 ng/mL, the serum CathG level of the MM patient group is 10.77 ng/mL. Serum CathG level in the control group is statistically significantly higher than the MM patient group. The aim of the present study is to contribute to the literature in hematological malignancies, to figure out the role of Cathepsin G in multiple myeloma, and to open a door to new treatment options for multiple myeloma, which is an incurable disease, yet.Öğe Diffuse Large B-Cell Lymphoma in adults aged 65 years and older: A retrospective multicenter analysis of clinical characteristics and therapeutic outcomes(CIG MEDIA GROUP, LP, 2015) Dogu, Mehmet Hilmi; Keklik, Muzaffer; Terzi, Hatice; Korkmaz, Serdal; Erkurt, Mehmet Ali; Cagliyan, Gulsum Akgun; Kaynar, Leylagul; Sivgin, Serdar; Sari, Ismail; Keskin, Ali; Sencan, Mehmet; Altuntas, Fevzi; Ilhan, Osman…Öğe Evaluation of in vitro anticancer activity of wheat germ oil in MCF-7 breast cancer cell lines(Sivas Cumhuriyet University, 2019) Ergül, Mustafa; Bekele, Adamu; Terzi, Hatice; Altun, AhmetCancer is the main cause of death and morbidity worldwide. Among females, breast cancer is the most commonly diagnosed and the leading cause of cancer-related death. Despite an improvement in the treatment of cancer in the latest years, metastatic breast cancer treatment success is not at a desirable level. Plants have huge potential to endow us with noble drugs and current drugs of plant origin are important part of cancer chemotherapy. The aim of this study was to evaluate the antiproliferative activity of wheat germ oil in MCF-7 breast cancer cell line. Antiproliferative activity and apoptotic effect of wheat germ oil were examined using the XTT and flow cytometry assay, respectively. According to the XTT results, at concentrations greater than 0.5 mg/mL, wheat germ oil displayed significant antiproliferative activity in MCF-7 cells in a dose-dependent manner. The Annexin V binding assay results also demonstrated that the IC50 concentration of wheat germ oil increased early and late apoptotic populations (p < 0.05). Though further studies are required to specifically identify compounds involved in the anticancer activity of wheat germ oil, our findings demonstrate that wheat germ oil inhibits proliferation of MCF-7 cells and its action is dose-dependent.Öğe Evaluation of potential cytotoxic and apoptotic effects of bioymifi on human multiple myeloma cell lines(Pharmacotherapy Group, 2020) Terzi, Hatice; Ergul, MervePurpose: To investigate the cytotoxic and apoptotic activities of bioymifi (DR5 agonist) on bortezomibsensitive and bortezomib-resistant cells. Methods: The cytotoxic activities of bioymifi against bortezomib-sensitive (U266) and bortezomib-resistant (U266/BR) cells were evaluated using XTT cell viability test. The cells were exposed to increasing concentrations of bioymifi for 24 h. Cell cycle analysis was performed while apoptosis was examined by flow cytometry. Results: Bioymifi showed significant cytotoxic effects on 0266 and U266/BR in a concentration-dependent manner (p < 0.05). The IC50 values of bioymifi in U266 and U266/BR cells were 10.4 and 20.9 mu M, respectively. Moreover, when compared to the untreated cells, bioymifi treatment at IC50 concentrations considerably increased the percentage of apoptotic cells. Bioymifi treatment also caused cell cycle arrest at the G2/M phase in both cell types. Conclusion: The results show that bioymifi is a promising candidate for multiple myeloma treatment. However, further studies are required to evaluate the clinical anticancer activity of this agent.Öğe Evaluation of the Antitumor Activity of Omipalisib, a PI3K/AKT/MTOR Pathway Inhibitor, on Burkitt Lymphoma Cell Line(2023) Keskin, Zekeriya; Yulak, Fatih; Terzi, Hatice; İnanır, MerveThere are many challenges in the treatment of Burkitt lymphoma, especially in immunocompromised individuals, elderly patients, and patients with relapsed or refractory disease. Therefore, there is a need for new and less toxic therapeutic agents. The aim of this study was to determine the antitumoral activity of omipalisib, a PI3K/AKT/mTOR pathway inhibitor, in the Burkitt lymphoma. Raji cell line was used in the study. Omipalisib was administered to the cell line and then the cytotoxic effect of omipalisib on Raji cells was evaluated by the XTT test. The IC50 value was calculated according to the results of the XTT test. Apoptosis and cell cycle experiments were studied with the calculated IC50 value. The flow cytometric method was used to determine the effect of omipalisib on apoptosis and cell death. The results of the study showed a statistically significant cytotoxic effect of increasing concentrations of omipalisib on Raji cells. The apoptosis experiment performed revealed that omipalisib strongly induced apoptosis. The cell cycle experiment showed that omipalisib stimulated the cell cycle arrest at the G0/G1 phase. It was concluded that omipalisib exhibited antitumoral activity on Burkitt lymphoma cells with its cytotoxic effect and induced apoptosis and cell cycle arrest. Considering this effect, targeting the PI3K/AKT/mTOR pathway with omipalisib can be a new treatment option.Öğe Examination of ototoxicity induced by imatinib, being a tyrosine kinase inhibitor: An experimental study(Wolters Kluwer Medknow Publications, 2020) Altuntas, Emine Elif; Durmus, Kasim; Bora, Adem; Turgut, Nergiz Hacer; Terzi, Hatice; Kutluhan, AhmetObjectives: Two rats were excluded from the study. Because otitis media developing one rat in Group C (7th dayof the experiment) and bleeding-related death one rat in Group I-50 (14th day of the experiment). While the side effects of imatinib are investigated in the literature, it is remarkable that the case reports suggesting an ototoxic side effect also take place among the publications. The aim of this study was to investigate whether or not imatinib has any ototoxic effect on rats via auditory brainstem response (ABR) responses. Materials and Methods: Rats were divided into three groups as Group C (0.25 mL/kg/day), Group I-30 (30 mg/kg/day), and Group I-50 (50 mg/kg/day). In the ABR record, hearing threshold, latency, amplitude, and interpeak latency values on test days were recorded and assessed. Results: In the assessment made in terms of mean V Wave latency within the group, a difference was determined at all stimulus intensities at 8 kHz in Group I-50 (P < 0.05). In the within-group assessment performed in terms of mean Wave III latency, there were differences in Groups I-30 and I-50 (P < 0.05). In the within-group assessment performed in terms of I-III interpeak latency mean values, there was a difference at 4 kHz and 70 dB in Group I-30 (P < 0.05). In the within-group assessment in terms of mean III-V interpeak latency values, the difference between the groups was significant on the 7th day at 6 kHz and 50 dB (P = 0.044) and on the 14th day at 8 kHz and 70 dB (P = 0.036). In the within-group assessment in terms of Wave I amplitude mean values, the change in the amplitude values at 4 kHz (P = 0.003) and 6 kHz (P = 0.018) in Group I-50 was significant. Conclusion: It was observed that imatinib application caused elongation in latency and interpeak latency values and changes in amplitude values. These differences were not enough to state that imatinib is having an ototoxic side effect.Öğe Examining the Early Period Effect of Nilotinib on Hearing: An Experimental Study(Aves, 2020) Bora, Adem; Durmus, Kasim; Terzi, Hatice; Altuntas, Emine ElifOBJECTIVES: Nilotinib has very few side effects, including neutropenia, thrombocytopenia, cardiotoxicity, high pancreatic lipase, ischemia, and vascular occlusion. We aimed to investigate whether short-term administration of nilotinib had ototoxic effects in rats. MATERIALS and METHODS: Wistar-albino rats were categorized into three groups: group C (administered 0.25 mL of distilled water, no nilotinib), group N-20 (administered 20 mg/kg/day of nilotinib dissolved in distilled water), and group N-50 (administered 50 mg/kg/day of nilotinib dissolved in distilled water). A single dose was administered once per day, at the same hour, over 21 days. Auditory brainstem response (ABR) thresholds were recorded on day 0 and day 21. RESULTS: There were no changes in ABR threshold values obtained on day 0 (baseline) and on day 21 across all three groups. A statistically significant difference was not found in terms of the mean latency of waves V and III, interpeak latency values of waves III-V, and amplitude ratios of waves III-V and V/Va at baseline and on day 21 across all three groups on within-group or between-group evaluation. CONCLUSION: Consequently, further studies are needed that involve different drug doses, prolonged administration of drugs, as well as distortion otoacoustic emission test for the evaluation of cochlear activation and ABR. Furthermore, histopathological studies are needed to indicate whether the cochlea is affected to prove that nilotinib has definitively no ototoxic effect.Öğe Executive functions and psychiatric disorders in adults with iron deficiency anemia(Cukurova Univ, Fac Medicine, 2023) Yilmaz, Yavuz; Terzi, Hatice; Tasova, BurakPurpose: The focus has been on the hematological complications of iron deficiency, while the nonhematological complications have been less studied. Its effects on cognitive functions were mostly investigated in children and adolescents. The purpose of this study is to compare the executive functioning of persons with iron deficiency anemia to healthy controls in order to determine whether they have any comorbid psychiatric disorders.Materials and Methods: 42 patients with iron deficiency anemia and 44 healthy controls participated in this study. To investigate whether any psychiatric disorders existed, the individuals were given a Structured Clinical Interview for DSM-5 Clinician's Version. Executive functioning was assessed using the Stroop Test and the Number Sequence Learning Test.Results: When compared to the control group, the IDA group took longer on average to complete parts 1-5 of the Stroop Test. There was no difference between the groups with regards to the results of number sequence learning test. Psychiatric illnesses were more common (43%) in the IDA group than they were in the control group (13.6%). The difference was significant when the groups were compared in terms of psychiatric disorders.Conclusion: According to the study's findings, those with iron deficiency anemia have worse executive functioning scores than healthy controls and are more likely to have psychiatric disorders. An extensive assessment of the health consequences of iron deficiency anemia is extremely important.Öğe Farklı bir bakış açısı ile plazma değişiminin hiperbilirubinemideki rolü(Sivas Cumhuriyet University, 2019) Terzi, Hatice; Korkmaz, Serdal; Şencan, Mehmet; Yönem, Özlem; Yılmaz, Abdulkerim; Ataseven, HilmiAmaç: Bu retrospektif çalışmada hiperbilirubinemiyi yönetme deneyimimizi sunmayı amaçladık.Yöntem: Çalışmaya Sivas Cumhuriyet Üniversitesi Tıp Fakültesi aferez ünitesinde 2006-2017 yılları arasında aferez tedavisi alan 21 hiperbilirubinemili hasta alındı. Hastaların dosyaları retrospektif olarak değerlendirildi ve şu veriler toplandı: hastanın yaşı, cinsiyeti, semptomları, plazma değişimi sayısı, adjuvan tedavi yöntemleri, sıvı replasmanı kullanımı, tedavi sonuçları ve plazma değişim komplikasyonları.Bulgular: Hastaların yaş ortalaması 57 idi (dağılım; 18-82). Ortalama plazma değişim sayısı 5,5'tir (aralık; 1-25). Sıvı değişimi için sadece taze donmuş plazma kullanıldı. Plazma öncesi ve sonrası değişim bilirubin düzeyleri arasında istatistiksel olarak anlamlı fark vardı (p <0.05). Toksik hepatit, hasta popülasyonumuzda en sık görülen hiperbilirubinemi nedeni idi. Hastalar plazma değişiminin yanı sıra, altta yatan durumuna uygun şekilde tedavi edildiler. Komplikasyon olarak, 2 hastada(% 8.69) allerjik reaksiyon ve 3 hastada(% 13) hipotansiyon gözlemledik. Sonuç: Plazma değişimi, bilirubinin uzaklaştırılması için güvenli bir yöntemdir. Ancak, plazma değişimi ve altta yatan durumun uygun tedavisi ile birlikte azalan hiperbilirubinemi, tedavide birincil amaç olmalıdır.Öğe Glomerülonefritli hastalarda vasküler endotelyal büyüme faktör g1154a ve c936t gen polimorfizmlerinin tedaviye yanıt ile olan ilişkisi(Cumhuriyet Üniversitesi, 2011) Terzi, Hatice; Kayataş, MansurGlomerülonefritler, temel olarak glomerülleri etkileyerek onların yapı ve fonksiyonunu bozan hastalıklardır. Glomerüller, böbreğin fonksiyonel en küçük birimi olan nefronların en önemli bölümü olup, fenestraları olan özelleşmiş bir endotele sahiptir.VEBF, endotel hücre proliferasyonunu, farklılaşmasını ve sağ kalımını destekleyen, endotel bağımlı vazodilatasyona aracılık eden, mikrovasküler hiperpermeabiliteyi uyaran, endotel hücre apoptozunu önleyerek vasküler canlılığı destekleyen ve interstisyel matriksin yeniden şekillenmesine iştirak eden endotele özgü bir büyüme faktörüdür.Bu çalışmada, erişkin glomerülonefritli olgularda, tedaviye yanıt oranı ile VEBF G-1154A (GG, GA, AA) ve C-936T (CC, CT, TT) gen polimorfizmleri arasındaki ilişkinin incelenmesi amaçlanmıştır. Böbrek biyopsisi ile patolojik olarak glomerülonefrit tanısı konulmuş ve en az 1g ve üzerinde proteinürisi olan 38 hasta çalışmaya dahil edildi. Hastalar 1 yıllık tedavi sonunda, 24 saatlik idrardaki proteinüri miktarı 0.5 g/gün ve altında ise tam remisyon ve 0.5 g/günün üzerinde ise remisyonda olmayan gruplar olarak 2 gruba ayrıldı. Çalışmaya dahil ettiğimiz bireylerin renal biyopsi sırasındaki yaşlarının ortalaması tam remisyonda olan grupta 35.88 ± 13.80 yıl, remisyonda olmayan grupta ise 37.30 ± 13.89 yıl idi. Tam remisyonda olan grupta bireylerin 9'u (% 50) erkek, 9'u (% 50) kadın olmak üzere toplam 18 hastadan, remisyonda olmayan grupta ise 7'si (% 35.0) erkek, 13'ü (% 65.0) kadın olmak üzere toplam 20 hastadan oluşmaktaydı. İki grup arasında laboratuvar ve demografik özellikler açısından bir fark bulunmadı (p>0.05).Tam remisyon grubundaki hastaların tanı anındaki proteinüri miktarı ortalama 3.19 gr/gün, tedavinin 12.ayındaki proteinüri miktarı ortalama 0.18 gr/gün idi. Remisyonda olmayan gruptaki hastaların tanı anındaki proteinüri miktarı ortalama 4.46 gr/gün, tedavinin 12.ayındaki proteinüri miktarı ise ortalama 2.19 gr/gün idi. Her iki grup arasındaki farklılık istatiksel olarak anlamlı bulunmuştur (p<0.05).Gruplar, VEBF G-1154A ve C-936T gen polimorfizmi yönünden karşılaştırıldığında ise G-1154A GA, AA ve C936T CC, CT, TT polimorfizmleri arasında önemli bir farklılığın olmadığı; oysa, VEBF G-1154A GG polimorfizminin remisyonda olmayan hastaların % 55 inde , tam remisyonda olan hastaların ise % 22.2 sinde pozitif olduğu; ancak, bu farklılğın da istatiksel olarak anlamlı bulunmadı (p>0.05).Sonuç olarak, glomerülonefritli hastalarda tedaviye tam remisyon yanıt oranı ile VEBF G-1154A ve C-936T gen polimorfizmleri arasında istatiksel olarak bir ilişki saptanmadı. Ancak VEBF G-1154A GG polimorfizmi açısndan iki grup arasında önemli bir farkın olduğu, bu durumun olgu sayımızın yetersiz olmasından dolayı istatistiksel olarak anlamlı bir düzeye ulaşmadığını; bu nedenle mevcut gen polimorfizmlerinin olgu sayısının daha fazla olduğu çalışmalarla irdelenmesinin uygun olacağını düşünmekteyiz.Anahtar Kelimeler: endotel, glomerülonefrit, VEBF gen polimorfizmi, proteinüriÖğe In vitro comparison of the cytotoxic effects of lenalidomide alone and in combination with verapamil on myeloma cell line(Wolters Kluwer Medknow Publications, 2021) Tastemur, Seyma; Sencan, Mehmet; Terzi, Hatice; Ergul, Merve; Tastemur, MercanIntroduction Multiple myeloma (MM) is a malignant hematological disease characterized by monoclonal proliferation of plasma cells. High-dose chemotherapy with novel agents and autologous stem cell transplantation are options for treatment. However, MM treatment generally results in failure. The most important reason for this failure is the resistance to chemotherapeutic drugs. Various studies have been tried to combine chemosensitizer agents that increase the cytotoxic effects of the chemotherapeutics to eliminate the drug resistance. In our study, we aimed to evaluate the effect of verapamil on the cytotoxic effect of lenalidomide on the myeloma cell line. Materials and methods Verapamil is a chemosensitizer that suppresses the P-glycoprotein. In our study, lenalidomide, an immunomodulatory agent, was compared alone and in combination with verapamil for cytotoxic effects. U266 MM cell line was used in the study. At the concentrations of 0.001, 0.01, 0.1, 1, 10, 50, and 100 mu M, lenalidomide alone and the combination of lenalidomide at the same concentrations with 2.5 mu g/ml of verapamil were compared in terms of possible cytotoxic properties. Cell viability was measured by XTT (2,3-bis (2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino) carbonyl]-2H-tetrazolium hydroxide) test. Results A statistically significant decrease in the inhibitor concentration, causing 50% decrease in cell proliferation (IC50) of lenalidomide, was provided via verapamil administration. Our study revealed that the cytotoxic effect of lenalidomide increases when combined with verapamil. Conclusion We aimed to understand whether the cytotoxic effect of lenalidomide, which has an important place in the treatment of MM, can be increased with an easily available drug such as verapamil. We think that more studies and meta-analyses are needed owing to the different results related to the subject in the literature, and we hope to set an example for new studies. (C) 2021 The Egyptian Journal of HaematologyÖğe In vitro comparison of the cytotoxic effects of statins on U266 myeloma cell line(Wolters Kluwer Medknow Publications, 2019) Terzi, Hatice; Altun, Ahmet; Sencan, MehmetBackground & objectives: Statins are one of the most widely used drugs and have antilipidemic effects as well as antioxidant, anti-inflammatory, anti-angiogenic and anti-tumorigenic effects. It has been shown that the synergistic combinations of statins which can provide better clinical benefit in the treatment of cancer and if administered with other anticancer agents, may be an alternative treatment modality. The aim of this study was to assess the efficacy of administrating statin in multiple myeloma (MM) cell line on cell proliferation. Methods: U266 myeloma cells were cultured in 25 or 75 cm[2] flasks by using cell culture medium mixtures obtained with the supplementation of 10 per cent foetal bovine serum and one per cent of penicillin-streptomycin into RPMI 1640 medium. When the cells reached confluence (reached to the density of 70%), they were reproduced by passaging. Cytotoxicity was evaluated by using the XTT test. Results: Statins (atorvastatin and simvastatin), were administered to the U266 myeloma cell line at 100, 50, 25, 12.5, 6.25 and 3.12 mu M concentrations. Inhibitor concentration 50 (IC50) values calculated for atorvastatin and simvastatin were determined as 94 and 38 mu M, respectively. While 100, 50, 25, 12.5, 6.25 and 3.12 mu M concentrations were used for bortezomib, the IC50value calculated for this agent was 18.2 nM. When six concentrations of bortezomib used in the study were combined with 12.5 mu M inactive concentrations of statins that did not cause inhibition in cell proliferation, both atorvastatin and simvastatin increased the effect of bortezomib at all the concentrations used, and simvastatin showed a stronger efficacy than atorvastatin. Interpretation & conclusions: Our in vitro results indicated that atorvastatin and simvastatin when used along with the conventional treatment in myeloma patients, may improve the effectiveness of the standard therapy and prevent the bortezomib-induced cytotoxic and neurotoxic side effects when used at a low dose. Further studies need to be done in MM patints to confirm these findings.Öğe Inflammation-Based Prognostic Factor in Different Forms of Chronic Suppurative Otitis Media(MEDKNOW PUBLICATIONS & MEDIA PVT LTD, 2017) Terzi, Hatice; Durmus, Kasim; Karatas, Tuba Dogan; Sencan, Mehmet; Altuntas, Emine ElifObjective: The aim of the present study was to investigate whether several blood tests could be used as inflammatory indicators in active or inactive chronic suppurative otitis media patients. Methods: Between 2007 to 2014, this study was conducted in 358 consecutive patients having chronic suppurative otitis media were included in the present retrospective clinical study. Patients were divided into two groups based on the clinical history, otologic examination, audiological evaluation and intraoperative finding. Group 1 consisted of 163 patients who had inactive chronic suppurative otitis media, while group 2 was comprised of 195 patients who had active chronic suppurative otitis media and cholesteatomatous otitis media. Results: With respect to the neutrophil-lymphocyte ratio (P = 0.001), the platelet-lymphocyte ratio (P = 0.001), absolute lymphocytes (P = 0.001), absolute neutrophil (P = 0.001), platelet (P = 0,001) and white blood cell (P = 0,02), Group 1 and Group 2 showed statistically significant differences. Conclusion: The results we obtained showed that markers such as neutrophil-lymphocyte ratio, the platelet-lymphocyte ratio, platelet, absolute neutrophil and white blood cell could be used as guide in evaluation of the prognosis of chronic suppurative otitis media.Öğe KAN ÜRÜNLERİNİN IŞINLANMASININ HASTALAR ÜZERİNDE OLUŞABİLECEK KOMPLİKASYONLARININ DEĞERLENDİRİLMESİ(Sivas Cumhuriyet Üniversitesi, 2023) Terzi, Hatice; İnanır, Merve; Yılmaz, Hüseyin; Yurtsever, İlkay; Şencan, MehmetGiriş: Kan transfüzyonu, çeşitli tıbbi durumlarda hayat kurtarıcı, ancak yüksek riskli bir işlem olup basit bir sıvı infüzyonu değil, bir organ naklidir. Kan transfüzyonu hayat kurtarıcı olsa da hayati tehlikeye yol açan ciddi reaksiyonlara neden olabilir. Günümüzde, kan ürünlerinin lökosit içeriklerinin azaltılması ya da ışınlanması ile reaksiyon sayıları ciddi oranda azalmıştır. Gereç ve Yöntem: Çalışmamızda 14.08.2020 ile 17.02.2023 tarihleri arasında hastanemizde ışınlanmış kan ürünü alan toplam 5582 hasta dahil edildi. Eritrosit süspansiyonu, trombosit aferezi ve havuzlamış trombosit süspansiyonu 25-30 Gy’lik dozlar halinde ışınlanarak hastalara verildi. Bulgular: Çalışmamızda 4990 eritrosit süspansiyonu, 282 havuzlanmış trombosit süspansiyonu, 310 trombosit aferezi olmak üzere toplam adet 5582 kan ürünü ışınlandı. Çalışmaya dahil edilen hiçbir hastada transfüzyon ilişkili Graft Versus Host Hastalığı saptanmamış olup, sadece hafif alerjik reaksiyon ve febril non-hemolitik transfüzyon reaksiyonları saptanmıştır. Sonuçlar: Çalışmamızdan elde edilen veriler doğrultusunda, kan ürünlerinin ışınlanması ile son derece ölümcül olan transfüzyon ilişkili Graft Versus Host Hastalığının önlenebileceği sonucuna vardık.Öğe Mean platelet volume in bipolar disorder: the search for an ideal biomarker(DOVE MEDICAL PRESS LTD, 2016) Mert, Derya Guliz; Terzi, HaticeBackground: The pathophysiology of bipolar disorder (BD) remains a mystery. In this context, interest in the role of the immune and inflammatory systems in BD has been increasing. We aimed to compare the routine hemogram values of BD patients with those of the participants in the healthy control group, to assess the inflammation levels of the two groups. Mean platelet volume (MPV) can be obtained as routine hemogram parameters and may aid in the detection of systemic inflammation. Subjects and methods: This study was conducted with BD (manic episode) inpatients (n=132) and healthy controls (n= 135). Abnormally distributed variables (ie, neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], neutrophils, lymphocytes, hemoglobin, hematocrit [HCT], mean corpuscular volume [MCV], mean corpuscular hemoglobin [MCH], mean corpuscular hemoglobin concentration [MCHC], red cell distribution width [RDW], MPV, and plateletcrit [PCT]) were compared using the Mann-Whitney U-test. Student's t-test was used to compare the mean ages and white blood cell, red blood cell, and platelet counts of the patients with BD against those of the participants in the control group. Results: The comparisons revealed that while the mean WBC and the median NLR, PLR, neutrophil, lymphocyte, MPV, and PCT values were significantly higher in the patients with BD (P<0.05), the median hemoglobin, RBC, HCT, and MCHC values were significantly higher in the control group (P<0.05). Conclusion: Comparisons of hemogram values of patients with BD against those of the healthy control group revealed that inflammatory cells (absolute neutrophil count, platelet count, PCT, and MPV) and ratios (NLR, PLR) seem to be altered during manic episodes. These findings support the hypothesis that inflammatory activation occurs in BD during manic episodes. In addition to NLR and PLR, MPV may be useful in the detection of this activation. The most significant limitation in the study is that smokers were not excluded in both groups. The development of new preventive and therapeutic options can be facilitated through the understanding of this mechanism because through this mechanism, inflammation may pathologically affect brain function, as well as inducing and/or perpetuating BD.
