Yazar "Tezel, Guler Bengusu" seçeneğine göre listele

Listeleniyor 1 - 1 / 1
  • Küçük Resim Yok
    Öğe
    SYNTHESIZE AND STABILITY ANALYSIS OF PEGYLATED NANOGRAPHENE OXIDE FOR DELIVERY OF DOXORUBICIN
    (Serban Solacolu Foundation, 2019) Cakmak, Nese Keklikcioglu; Tezel, Guler Bengusu
    In this study, graphene oxide nanoparticle (NGO) was fabricated via modified Hummers' method and then modified with amine terminated 4-armed PEG to enhance the biocompatibility and stability of nano drug carrier. In our strategy, Doxorubicin (DOX) was used as a model drug. DOX loading onto NGO-PEG was synthesized by simply mixing with the NGO-PEG solution at pH 7 overnight. NGO, NGO-PEG and NGO-PEG-DOX was characterized by power X-ray diffraction, scanning electron microscopy, and UV spectroscopy. Stability analysis was performed with zeta potential. The experimental results showed that the zeta potential analysis values were above +/- 40 mV. NGO-PEG-DOX is still had very good dispersion stability even after 45 days. Therefore, this drug loaded product can be good candidate for treatment of cancer.