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  • Küçük Resim Yok
    Öğe
    Apikal rezeksiyon operasyonlarında trombositten zengin fibrin uygulaması: Olgu serisi
    (2019) Yıldırım, Ali; Toker, Hülya; Kanmaz, Fatma; Altunbaş, Nilüfer
    Apikal rezeksiyon sonrası oluşturulan kemik kavitelerininiyileşmeleri sırasında her zaman istenilen sonuçlar elde edilememektedir.Bu nedenle apikal rezeksiyon kavitelerinderejeneratif tedaviler uygulanmaya başlanmıştır. Trombosittenzengin fibrin (TZF) bireyin kanının santrifüj edilerek trombositve büyüme faktörlerinden zengin bir membran elde etmeyisağlayan ikinci nesil trombosit ürünüdür. Bu vaka serisindeapikal rezeksiyon işlemi sonrası operasyon bölgesine yerleştirilenTZF’nin klinik ve radyografik olarak sonuçları sunulmuştur.Endodonti kliniğinden apikal rezeksiyon endikasyonu ile sevkedilen 3 hastaya cerrahi işlem sırasında periapikaldeki tümnekrotik ve iltihaplı dokunun küretajı yapılmış ve defekt bölgesinehastalardan alınan venöz kanın santrifüj edilmesiylehazırlanan TZF uygulanarak yara yeri süture edilmiştir.Hastaların periyodik kontrollerindeki klinik ve radyografiksonuçlarına göre; TZF’nin kemik kavitesi boşluğunun rejenerasyonundaetkili olduğu ve konvansiyonel cerrahi tedaviyealternatif bir rejeneratif tedavi şekli olabileceği kanısındayız.
  • Küçük Resim Yok
    Öğe
    Ozone improves autogenous graft healing in experimental diabetes mellitus: A morphometric and immunohistochemical study
    (2020) Alpan, Aysan Lektemur; Toker, Hülya; Özer, Hatice
    Background: Diabetes mellitus (DM) is a metabolic disorder whichplays crucial role in the pathogenesis of periodontitis. Ozone haveseveral actions such as antimicrobial, immunostimulating,antihypoxic effects, and activates antioxidant enzymes andangiogenesis. The aim of this study is to investigate the effect ofgaseous ozone on bone healing in diabetic rat calvarial defectstreated with autogenous bone graft, morphometrically andimmunohistochemically.Material and Methods: Diabetes was induced and critical sizedefects were created on rats. Study groups: 1-Empty defect(Control, n=14) group, 2-Autograft (AG, n=14) group, 3-Emptydefect+ozone therapy (Control+Ozone, n=14) group, 4-Autograft+ozone application (AG+Ozone, n=14) group. Gaseousozone was applied on the operation day and the following 2 weeksdaily (140ppm @ 2L/d, 2.24 mg). Total bone area was measured.Osteocalcin and Bone morphogenic protein-2 protein expressionswere evaluated.Results: Control and Control+Ozone groups had no osteoclastand residuel lacunae during the study . Osteoblasts in AG+Ozonegroup were higher than AG group at 4th week (p>0.05).AG+Ozone group had more total bone area than AG group at 4thweek. AG+Ozone group revealed more BMP-2 immune positivitycompared to the other groups. Osteocalcin immune positivity inAG groups was higher than those of the Control groups.Conclusion: Within the limitations of this study, gaseous ozoneapplication decreased osteoclast number and increasedosteoblast number and bone regeneration, especially, in earlystages of bone regeneration in diabetic rats
  • Küçük Resim Yok
    Öğe
    OZONE IMPROVES AUTOGENOUS GRAFT HEALING IN EXPERIMENTAL DIABETES MELLITUS: A MORPHOMETRIC AND IMMUNOHISTOCHEMICAL STUDY
    (Selcuk University, 2020) Alpan, Aysan Lektemür; Toker, Hülya; Özer, Hatice
    Amaç: Diabetes mellitus (DM) is a metabolic disorder which plays crucial role in the pathogenesis of periodontitis. Ozone have several actions such as antimicrobial ,immunostimulating, antihypoxic effects, and activates antioxidant enzymes and angiogenesis. The aim of this study is to investigate the effect of gaseous ozone on bone healing in diabetic rat calvarial defects treated with autogenous bone graft, morphometrically and immunohistochemicallyGereç ve Yöntemler:Diabetes was induced and critical size defects were created on rats. Study groups: 1-Empty defect (Control, n=14) group, 2-Autograft (AG, n=14) group, 3-Empty defect+ozone therapy (Control+Ozone, n=14) group, 4-Autograft+ozone application (AG+Ozone, n=14) group. Gaseous ozone was applied on the operation day and the following 2 weeks daily (140ppm @ 2L/d, 2.24 mg). Total bone area was measured. Osteocalcin and Bone morphogenic protein-2  protein expressions were evaluated.Bulgular:Control and Control+Ozone groups had no osteoclast and residuel lacunae during the study . Osteoblasts in AG+Ozone group were higher than AG group at 4th week (p>0.05). AG+Ozone group had more total bone area than AG group at 4th week. AG+Ozone group revealed more BMP-2 immune positivity compared to the other groups. Osteocalcin immune positivity in AG groups was higher than those of the Control groups.Sonuçlar:Anahtar Kelimeler: