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Application of Topical/Subconjunctival Bevacizumab and Topical Fluorometholone Acetate in Alkali Burn-induced Model of Corneal Angiogenesis
(Turkish Ophthalmological Soc, 2010) Dursun, Ayhan; Arici, Mustafa Kemal; Ozec, Ayse Vural; Dursun, Feyza; Toker, Mustafa Ilker; Topalkara, Aysen
Purpose: To investigate the effect of bevacizumab on corneal neovascularization in an alkali burn -induced model of corneal angiogenesis. Material and Method: Twenty-four Wistar albino rats were used in our study. After chemical cauterization of the cornea, the rats were divided randomly into four groups. Group 1 (control group) received artificial tears twice a day, group 2 received topical fluorometholone acetate twice a day, in group 3, a single dose of bevacizumab (2.5 mg) was administered by a subconjunctival injection, and group 4 received topical bevacizumab 5mg/ml twice a day. Three weeks later, the rat corneas were evaluated by slit-lamp biomicroscopy and corneal photographs were taken with a digital camera, followed by sacrifice of the subjects. The proportional area of vascularized cornea, length of the longest neovascular sprout, corneal oedema and corneal opacity score were assessed. Result: The analysis of digital photographs showed less corneal neovascularization, corneal oedema, corneal opacity score and shorter length of the longest neovascular sprout in the three drug groups than in the control one (p<0.05). The area of corneal neovascularization in groups 3 and 4 was less than in group 2 (p=0.035 and p=0.027, respectively). Corneal neovascularization, corneal oedema and corneal opacity did not differ significantly between the subconjunctival and topical bevacizumab groups. However, statistically significant decrease was observed in the length of the longest neovascular sprout in the topical bevacizumab group (p=0.029). Discussion: Subconjunctival/topical bevacizumab treatment is an effective method in reducing corneal neovascularization. However, we observed that topical bevadzumab is more efficient than subconjunctival bevacizumab and fluorometholone acetate in preventing corneal neovascularization.
Aqueous humour levels of ghrelin in exfoliation syndrome and exfoliation glaucoma patients
(SPRINGER JAPAN KK, 2014) Ozec, Ayse Vural; Dursun, Ayhan; Toker, Mustafa Ilker; Demirci, Yuksel; Topalkara, Aysen; Erdogan, Haydar; Arici, Mustafa Kemal; Ersalcan, Taner
Purpose To investigate levels of ghrelin in the aqueous humour (AqH) of patients with exfoliation syndrome and exfoliation glaucoma and compare them to levels of ghrelin in control subjects. Methods This cross-sectional study involved 15 patients with exfoliation syndrome, 8 with exfoliation glaucoma and 12 control subjects for whom cataract surgery was indicated. The AqH was aspirated from the anterior chamber with a 27-G needle under sterile conditions prior to tissue manipulation. Ghrelin levels were quantified using radioimmunassay kits. Results Levels of ghrelin in the AqH were 187.87 +/- 80.1 pg/mL in the eyes exhibiting exfoliation syndrome, 98.53 +/- 50.9 pg/mL in the eyes exhibiting exfoliation glaucoma and 111.40 +/- 77.5 pg/mL in the controls. Ghrelin level of patients with exfoliation syndrome were significantly higher than those of patients with exfoliation glaucoma and the controls (P<0.05). Ghrelin levels of patients with exfoliation glaucoma were lower than those of the controls but were not reach statistically significant (P>0.05). Age, gender and IOP did not have a significant effect on ghrelin levels in patients with exfoliation syndrome and exfoliation glaucoma. Conclusion This study is the first to report elevated levels of ghrelin in the AqH in eyes exhibiting exfoliation syndrome. Findings suggest ghrelin might play role in the etiopathogenesis of exfoliation syndrome to exfoliation glaucoma.
The Association between Diabetic Retinopathy and Levels of Ischemia-Modified Albumin, Total Thiol, Total Antioxidant Capacity, and Total Oxidative Stress in Serum and Aqueous Humor
(HINDAWI PUBLISHING CORPORATION, 2014) Kirboga, Kadir; Ozec, Ayse V.; Kosker, Mustafa; Dursun, Ayhan; Toker, Mustafa I.; Aydin, Huseyin; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa K.
Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P = 0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P = 0.004). Mean TOS levels in the serum were 2.93 +/- 0.19 in the DRP group and 2.61 +/- 0.26 in the control group (P = 0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.
Association of neutrophil/lymphocyte ratio and retinal vein occlusion
(WICHTIG PUBL, 2015) Dursun, Ayhan; Ozturk, Sultan; Yucel, Hasan; Ozec, Ayse Vural; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Topalkara, Aysen
Purpose: To evaluate the association between neutrophil/lymphocyte ratio (NLR) and the development of retinal vein occlusion (RVO). Methods: Forty patients were included in the study. Forty age- and sex-matched healthy volunteers were recruited as the control group. The RVO diagnosis was made clinically, based on the findings of fundus examination. The NLR and file records of the patients and the control group were compared. Results: The mean age of patients was 64 +/- 12 years. Neutrophil levels were higher in RVO patients compared to the control subjects (5.1 +/- 1.9 vs 3.6 +/- 1.0, p<0.001). Lymphocyte levels were lower in RVO patients compared with the control subjects (2.0 +/- 0.7 vs 2.6 +/- 0.9, p = 0.005). The NLR was significantly higher in RVO patients compared with the control subjects (3.0 +/- 2.7 vs 1.5 +/- 0.3, p<0.001). According to the receiver operator characteristics curve analysis, the optimal cutoff value of NLR to predict RVO was > 1.89, with 72.5% sensitivity and 100% specificity. Conclusions: The current study demonstrated that higher NLR was associated with the development of RVO. The NLR may be used as a predictive tool for identifying risk for RVO.
Bilateral-14.0 diopters index myopia successfully treated with cataract surgery - A case report
(HUMANA PRESS INC, 2006) Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Kal, Ali; Topalkara, Aysen; Arslan, Osman Sevki
We report a 60-year-old man with bilateral nuclear cataract and -14.0 diopters index myopia. Following uncomplicated phacoemulsifications and posterior chamber intraocular lens implantations on both eyes, right and left axial lengths were 22.58 and 22.60, mm with otobiomeric A-scan ultrasound, respectively. Three-month corrected visual acuity was 20/20 in the right eye with a -1.00 x 130 degrees cylinder and 20/20 in the left eye with -0.50 spheres and -1.00 x 100 degrees cylinders.
Central corneal thickness and Diaton transpalpebral tonometry
(SPRINGER, 2008) Toker, Mustafa Ilker; Vural, Ayse; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa Kemal
Background To examine the effects of central corneal thickness on the measures obtained from transpalpebral tonometry (Diaton), and to identify correlations between intraocular pressure (IOP) measurements with Diaton and the Goldmann applanation tonometer (GAT). Methods In this cross-sectional study, 162 eyes of 81 participants were included. Intraocular pressure measurements were obtained in all patients using Diaton and GAT. Central corneal thickness was determined by ultrasound pachymetry. The participants were stratified by corneal thickness: group I < 530 mu m (n=56), group II 530-560 mu m (n=65), and group III > 560 mu m (n=41). Results There were moderate correlations between IOP readings obtained using the Diaton and corrected GAT (C-GAT) (r=0.303; P < 0.0001), and between corrected Diaton (C-Diaton), and C-GAT (r=0.399; P0.0001). The mean Diaton tonometer readings were lower than C-GAT measurements (Diaton-corrected GAT mean difference, 0.9 +/- 3.8 mmHg; c-Diaton-corrected GAT mean difference, 0.7 +/- 3.5 mmHg). Differences were detected between the groups of patients for the GAT values [2.4 +/- 3.6 mmHg for those with the thinnest corneas (< 530 mu m), 0.7 +/- 3.6 mmHg for those with moderate corneas (between 531 mu m and 560 mu m), and -0.6 +/- 3.6 mmHg for those with the thickest (> 560 mu m) corneas], whereas a significantly lower difference (0.9 +/- 3.8 mmHg) was noted for the Diaton values of all individuals. Conclusions The Diaton measurements show moderate correlation with those provided by applanation tonometry. The Diaton tonometer seems to be more affected by the corneal thickness, especially in the thinnest corneas.
Comparison of the effects of bevacizumab and ranibizumab injection on corneal angiogenesis in an alkali burn induced model
(IJO PRESS, 2012) Dursun, Ayhan; Arici, Mustafa Kemal; Dursun, Feyza; Ozec, Ayse Vural; Toker, Mustafa Ilker; Erdogan, Haydar; Topalkara, Aysen
AIM: To investigate the effects of bevacizumab and ranibizumab on corneal neovascularization in an alkali bum-induced model of corneal angiogenesis. METHODS: Fifteen Wistar-Albino rats were divided randomly into 3 groups after chemical cauterization of the cornea. The first group received a single dose of 0.1mL saline solution as a control group whereas second and third groups received a single dose of 2.5mg bevacizumab or 1mg ranibizumab by subconjunctival injection, respectively. After three weeks, the rat corneas were evaluated by biomicroscopy and corneal photographs were taken. The percentage of neovascularization area, length of the longest new vessel, corneal oedema and corneal opacity scores were assessed. RESULTS: The analysis of digital photographs showed that the percentage of neovascularization area to the total corneal area, the length of the longest new vessel, corneal oedema and opacity scores were significantly lower in both study groups compared to the control group (P<0.05). Additionally, the percentage of corneal neovascularization area, the length of the longest new vessel and corneal opacity score were less with bevacizumab than ranibizumab. CONCLUSION: Subconjunctival bevacizumab and ranibizumab treatments may be effective methods in reducing corneal neovascularization Furthermore, bevacizumab is more effective than ranibizumab in the inhibition of corneal neovascularization.
Effect of latanoprost/timolol and dorzolamide/tiomolol on intraocular pressure after phacoemulsification surgery
(IJO PRESS, 2011) Erdogan, Haydar; Ozec, Ayse Vural; Caner, Cengiz; Toker, Mustafa Ilker; Arici, Mustafa Kemal; Topalkara, Aysen
AIM: To evalaute the effect of fixed-combination latanoprost 0.005% /timolol maleate 0.5% and dorzolamide hydrochloride 2% /timolol maleate 0.5% on postoperative intraocular pressure after phacoemulsification cataract surgery. METHODS: This study is a prospective, randomized, double-masked and placebo-controlled. The study included 90 eyes of 90 patients which were scheduled to have phacoemulsification surgery. Patients were randomly assigned preoperatively to 1 of 3 groups (30 eyes of 30 patients). Two hour before surgery, the patients received one drop latanoprost/timolol (group 1), dorzolamide/timolol (group 2) and placebo (group 3, control group). The IOPs were measured at preoperative and postoperative 4, 8, and 24 hours. RESULTS: The preoperative mean intraocular pressure was not statistically significant between both drug groups and control group. In group 1 and 2, the postoperative mean TOP [group1: (14.03 +/- 3.15)mmHg and group 2: (14.16 +/- 4.43) mmHg] at 24 hours were significantly lower than the control group [(16.93 +/- 3.70)mmHg, (P < 0.05)]. In addition, the postoperative mean IOP of group 1 [(14.90? .69)mmHg] at 8 hours was significantly lower than the control group [(17.70 +/- 3.89)mmHg, (P < 0.05)], but there was no significant difference between group 2 [(16.16 +/- 5.23)mmHg] and control group at 8 hours (P > 0.05). CONCLUSION: When compared with placebo, the use of preoperative fixed combination of latanoprost/timolol and dorzolamide/timolol is an effective method for preventing intraocular pressure elevation in 24 hours after phacoemulsification surgery, but did not completely prevent TOP spikes.
The effect of propolis in experimental Acanthamoeba keratitis
(WILEY, 2007) Vural, Ayse; Polat, Zubeyde Akin; Topalkara, Aysen; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal; Cetin, Ali
Purpose: To examine the effect of propolis in a rat model of Acanthamoeba keratitis and to determine its in vitro cytotoxicity in cultured corneal epithelial cells. Methods: Eighteen Wistar albino rats were used. Cultured corneal epithelial cells obtained from two healthy rats for in vitro cytotoxicity of propolis. Corneal stromal inoculation was performed in 16 rats with amoebic culture containing 1 x 10(6) amoeba/mL. Rats with Acanthamoeba keratitis 5 days later after the inoculation were divided randomly into four groups, and eight eyes of each group were treated with study drugs. The propolis, chlorhexidine (CHX), propolis plus CHX and control eyes were treated with topical propolis, 0.002% CHX, propolis plus 0.002% CHX and lubricant eye drops, respectively. The study drugs were instilled every one hour for 10 days. All eyes were examined and keratitis graded by slit-lamp biomicroscopy on days 2, 5 and 10 during the administration of the study drugs. After the completion of keratitis grading, all the 16 rats were humanely killed and their corneas were excised and used for Acanthamoeba culture to evaluate presence of Acanthamoeba growth after treatment 14 days later. Results: Concentrations of propolis higher than 7.81 mg/mL cause damage to corneal epithelial cells in the experiment of in vitro cytotoxicity of propolis on corneal epithelial cells. The keratitis grade on day 2 in the CHX eyes was significantly lower than that in the control eyes (P < 0.05). The keratitis grades on days 5 and 10 in the propolis, CHX and propolis plus CHX eyes were significantly lower compared with those on days 5 and 10 in the control eyes (P < 0.05). In the propolis eyes, the keratitis grade on day 5 was significantly lower than that on day 2 (P < 0.05), and it was significantly lower on day 10 compared with that on day 5 (P < 0.05). In the CHX and propolis plus CHX eyes, the keratitis grade on day 10 was significantly lower compared with that on days 2 and 5 (P < 0.05). In the control eyes, there was no significant difference in the keratitis grades on days 2, 5 and 10 (P > 0.05). The culture positivity at Acanthamoeba growth after treatment experiment in the propolis, CHX and propolis plus CHX eyes was significantly lower than that in the control eyes (P < 0.05). Conclusions: We suggest that propolis had amoebicidal properties in this rat model of Acanthamoeba keratitis. Further investigations to evaluate the antimicrobial activity of the individual fractions of the resin could yield more information about its mechanism of action in treating this disease.
Efficacy of First Turkish Made Single-Piece Foldable Hydrophobic Acrylic Intraocular Lens Zaraccom F260 on Cataract Treatment
(AMER SOC CONTEMPORARY MEDICINE SURGERY & OPHTHALMOLOGY, 2008) Toker, Mustafa Ilker; Vural, Ayse; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa Kemal
We evaluated the efficacy of Zaraccom F260 intraocular lenses (IOL) on cataract treatment in 97 adult cataract patients (114 eyes) who underwent phacoemulsification and IOL implantation. The mean preoperative best-corrected visual acuity (BCVA) was 0.26 +/- 0.26 at one week 0.49 +/- 0.25 and 0.9 +/- 0.28 at follow-ups. The Zaraccom F260 is an alternative for the patients requiring lens replacement.
Evaluation of Choroidal Thickness in Patients with Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma
(HINDAWI PUBLISHING CORP, 2016) Dursun, Ayhan; Ozec, Ayse Vural; Dogan, Oznur; Dursun, Feyza Gulac; Toker, Mustafa Ilker; Topalkara, Aysen; Arici, Mustafa Kemal; Erdogan, Haydar
Purpose. To compare the macular and peripapillary choroidal thickness in eyes with pseudoexfoliation (PEX) syndrome and PEX glaucoma with the normal eyes of healthy controls. Materials and Methods. In this prospective study, 30 eyes of 30 patients with PEX syndrome, 28 eyes of 28 patients with PEX glaucoma, and 30 eyes of 30 age-matched healthy subjects were enrolled. Choroidal thicknesses in the macular and peripapillary areas were measured by using spectral domain optical coherence tomography. Results. Gender, age, and axial length did not significantly differ between the groups (all, p > 0.05). The mean values of choroidal thickness in the macular and peripapillary areas (except the superior quadrant) in the patients with PEX syndrome and PEX glaucoma were lower compared with controls (all p < 0.05). The mean values of the macular and peripapillary choroidal thickness in the PEX glaucoma group were lower compared with PEX syndrome group; however this difference was not significant. Conclusions. The findings of this study revealed that macular and peripapillary choroidal thicknesses were decreased in PEX syndrome and PEX glaucoma cases. The role of choroid in the development of glaucomatous damage in patients with PEX syndrome remains unclear.
Evaluation of Serum Homocysteine and Leptin Levels in Patients with Uveitis
(TURKISH OPHTHALMOLOGICAL SOC, 2015) Elbay, Arif Emre; Topalkara, Aysen; Elbay, Ahmet; Erdogan, Haydar; Vural, Ayse; Cetin, Abdi Bahadir
Objectives: To evaluate the serum homocysteine (Hcy) and leptin levels in patients with uveitis. Materials and Methods: The 70 cases included in the study comprised 3 groups: patients with Behcet's uveitis (BU), patients with non-Behcet's uveitis (NBU) and healthy controls. Body mass index was calculated for each subject. Serum Hcy and leptin levels were measured. Furthermore, acute-phase reactants including erythrocyte sedimentation rate (ESR), C-reactive protein and neutrophil count were measured. Results: Serum Hcy levels were 15.04 +/- 4.59 mu mol/L in the BU group, 15.4 +/- 6.87 mu mol/L in the NBU group and 13.64 +/- 4.72 mu mol/L in the control group (p>0.05). The serum leptin levels of male patients in the BU group, NBU group and control group were 4.76 +/- 3.54 ng/ml, 6.33 +/- 3.74 ng/ml and 5.47 +/- 6.33 ng/ml, respectively (p>0.05). When we compared serum leptin levels in female patients and controls, the mean serum leptin concentrations were significantly higher in female BU and NBU patients (24.83 +/- 17.62 ng/ml and 28.46 +/- 13.90 ng/ml, respectively) than in healthy control volunteers (9.62 +/- 6.36 ng/ml, p<0.05). In addition, the ESR value differences between groups were statistically significant (p<0.05). Conclusion: A larger case series is necessary to investigate serum Hcy and leptin concentrations in uveitis patients.
In vitro amoebicidal activity of propolis on Acanthamoeba castellanii
(MARY ANN LIEBERT INC, 2007) Topalkara, Aysen; Vural, Ayse; Polat, Zubeyde; Toker, Mustafa I.; Arici, Mustafa K.; Ozan, Fatih; Cetin, Ali
Purpose: The aim of this study was to investigate the in vitro effects of an ethanolic extract of propolis on the growth and adherence of Acanthamoeba castellanii trophozoites and cysts. Methods: The effect of propolis with concentrations of 8.0, 6.0, 5.0, 4.0, 3.0, and 2.0 mg/mL on the proliferation of A. castellanii trophozoites, and with a concentration of 62.25, 31.25, 15.62, 7.81, 3.90, 1.95, and 0.97 mg/mL on the proliferation of A. castellanii cysts, at 1, 3, 6, 12, 24, 48, and 72 h were examined in vitro.. Results: After 1-72 h, incubation in concentrations between 2.0 and 6.0 mg/mL, its effect was amoebistatic; at concentrations of 8.0 mg/mL and higher, its effect was amoebicidal. After 48 h or longer incubation times at 15.62 mg/mL and at higher concentrations, the propolis extract was cysticidal. At concentrations of 1.97 mg/mL or lower, there was no observable effect at any time point. Conclusions: These findings indicate that ethanolic extract of propolis has amoebicidal, as well as cysticidal, properties for Acanthamoeba trophozoites and cysts. Propolis alone, or in combination with other amoebicidal agents, may be used in clinical practice after further investigations.
Nifedipine Enhances the Relaxant Effects of Cyclo-Oxygenase Inhibitors on the Bovine Ciliary Muscle
(MARY ANN LIEBERT, INC, 2008) Toker, Mustafa; Bagcivan, Ihsan; Topalkara, Aysen; Karadas, Baris; Durmus, Nedim; Parlak, Ahmet; Kaya, Tijen
Background/Aims: The inhibition of cyclo-oxygenase (COX) enzymes and the blockade of Ca2+ channels play an important role in the regulation of smooth muscle relaxation. This study was designed to investigate the relaxant effects of celecoxib, DFU (5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulphonyl)phenyl-2(5H)-furanone), and indomethacin, cyclo-oxygenase (COX-1 and -2) inhibitors, in the absence or presence of a nifedipine, L-type Ca2+ channel blocker, on bovine ciliary muscle. Methods: Ciliary muscle strips (n = 12) were mounted in organ baths and tested for changes in isometric tension in response to celecoxib, DFU, and indomethacin. The relaxant effects of celecoxib, DFU, and indomethacin on carbachol-induced contractions in the presence or absence of nifedipine were investigated. Results: Celecoxib (10(-7)-10(-4) M), DFU (10(-7)-10(-4) M), indomethacin (10(-7)-10(-4) M), and nifedipine (10(-7)-10(-4) M) inhibited the carbachol-induced contractions in a concentration-dependent manner. The Em x value of indomethacin was significantly higher than the E-max values of celecoxib and DFU in ciliary muscle (P < 0.05), with no significant change in pD(2) values (P > 0.05). The relaxation responses by celecoxib, DFU, and indomethacin were significantly increased in the presence of nifedipine (10(-6) M). There were no significant differences between pEC50 and values of celecoxib, DFU, and indomethacin in the absence of nifedipine (10-6 M) (P > 0.05), but E-max values were significantly increased (P < 0.05). Conclusions: These results suggest that the celecoxib, DFU, and indomethacin cause relaxation in ciliary muscle precontracted with carbachol. Blockade of calcium channels with nifedipine in ciliary muscle may increase the relaxant effect of celecoxib, DFU, and indomethacin. The topical or systemic use of celecoxib, DFU, and indomethacin with nifedipine can cause blurred near vision due to ciliary muscle relaxation, and in ocular pain conditions caused by ciliary spasm, the pain can be decreased more easily by combined use of these drugs.
Relationship between mean platelet volume and central serous chorioretinopathy
(SPRINGER, 2017) Dursun, Ayhan; Toker, Mustafa Ilker; Ozec, Ayse Vural; Bozali, Erman; Kirboga, Kadir; Dursun, Feyza Gulac; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa Kemal
The aim of this study was to investigate the mean platelet volume (MPV) of patients with central serous chorioretinopathy (CSCR). Thirty patients were included in the study. Thirty healthy volunteers were recruited as the control group. All patients and control subjects underwent complete ocular examination. Hemoglobin, hematocrit, white blood cell, neutrophil, lymphocyte, platelet count, and MPV of the participants were recorded. Data of patients with CSCR were compared with the control subjects. Patients with CSCR had significantly higher MPV values (9.76 +/- 1.36 fL) compared with the control subjects (8.37 +/- 0.72 fL) (p = 0.004). No significant difference was found in platelet counts between the CSCR group and the control group (259 +/- 53.75 and 243 +/- 52.11 K/Ul, p = 0.253). According to the receiver operator characteristics curve analysis, the optimal cut-off value of MPV to predict the CSCR was > 9.4, with 60.0 % sensitivity and 93.3 % specificity. Our results demonstrated that the MPV values were significantly higher in patients with CSCR. MPV may be used as a predictive tool for identifying risk for CSCR.
Relaxant effects of beta-adrenoceptor agonist formoterol and BRL 37344 on bovine iris sphincter and ciliary muscle
(ELSEVIER SCIENCE BV, 2006) Topalkara, Aysen; Karadas, Baris; Toker, Mustafa I.; Kaya, Tijen; Durmus, Nedim; Turgut, Bulent
We investigated the relaxant effect Of beta(2)-adrenoceptor agonist formoterol and beta(3)-adrenoceptor agonist BRL 37344 on bovine iris sphincter and ciliary muscle and measured CAMP and cGMP levels. his sphincter (n = 16) and ciliary muscle (n = 16) strips were mounted in organ baths and tested for changes in isometric tension in response to formoterol and BRL 37344. Their relaxant effects on serotonin-induced contractions in the presence or absence of metoprolol, ICI 118.551 and SR 59230A (beta(1)-, beta(2)-, beta(3)-adrenoceptor antagonist, respectively) were investigated. Their effects on CAMP and cGMP levels in iris sphincter (n = 12) and ciliary muscle (n = 12) were evaluated. Formoterol (10(-11)-10(-5) M) and BRL 37344 (10(-10)-10(-5) M) decreased the serotonine-induced contractions in a concentration-dependent manner. E-max values of formoterol were significantly higher than those of BRL 37344 in iris sphincter and ciliary muscle, with no significant change in pD(2) values. The relaxation responses by formoterol and BRL 37344 were antagonized with ICI 118.551 (10(-6) M) and SR 59230A (10(-6) M). CAMP levels of formoterol- and BRL 37344-treated tissues were significantly higher than those of the control tissues. cGMP levels of BRL 37344-treated tissues were significantly higher than those of control tissues, but this effect of BRL 37344 was less significant than its effect on CAMP levels. beta-adrenoceptor relaxation responses in bovine iris sphincter and ciliary muscle are mediated by a mixed population Of beta(2)- and beta(3)-adrenoceptor subtypes, with a predominant contribution of cAMP. Potency of formoterol and BRL 37344 was similar, but efficacy of formoterol was better than BRL 37344. (c) 2006 Elsevier B.V. All rights reserved.
Results of Screening in Schools for Visually Impaired Children
(TURKISH OPHTHALMOLOGICAL SOC, 2017) Kiziltunc, Pinar Bingol; Idil, Aysun; Atilla, Huban; Topalkara, Aysen; Alay, Cem
Objectives: The aim of this study was to identify the causes of visual impairment in children attending schools for students with visual impairment and to identify children suitable for treatment and rehabilitation. Materials and Methods: All students were examined in our department by a pediatric ophthalmologist and an ophthalmologist experienced in low vision and visual rehabilitation. The children's medical histories were recorded. All children underwent ophthalmological examination including visual acuity measurement, anterior segment and dilated fundus evaluation, retinoscopy with cycloplegia, and intraocular pressure measurement. The causes of visual impairment were grouped as avoidable and unavoidable. Children with residual visual acuity better than 20/1250 were included in the low vision rehabilitation programme. Results: A total of 120 patients were evaluated and 79.2% were legally blind (visual acuity less than 0.05), 18.4% had low vision (visual acuity between 0.05 and 0.3), and 0.8% had normal vision (> 0.3). The main causes of visual impairment were retinal dystrophies (24.2%) and retinopathy of prematurity (17.5%). Of all diseases related to visual impairment, 27.6% were avoidable. Improvement in visual acuity was achieved with low vision aids in 57.5% of all patients. Conclusion: The incidence of visual impairment due to avoidable causes can be decreased by ophthalmic screening. Treatment of these children in the early stages of visual development can improve visual acuity. Even in cases with delayed diagnosis, low vision aids are important for visual and neurobehavioral development, and these programmes may improve quality of life and education in these children.
Total oxidative stress, paraoxonase and arylesterase levels at patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma
(IJO PRESS, 2015) Dursan, Feyza; Ozec, Ayse Vural; Aydin, Huseyin; Topalkara, Aysen; Darsun, Ayhan; Toker, Mustafa Ilker; Erdogan, Haydar; Arici, Mustafa Kemal
AIM: To investigate the oxidative stress status of the aqueous humor and serum of patients with pseudoexfoliation (PEX) syndrome and pseudoexfoliative glaucoma (PEG) and to measure paraoxonase (PON) and arylesterase (ARE) levels. METHODS: A total of 78 patients were enrolled in the study, with 26 patients in each separate group. The patients were divided into three groups: the first group entailed PEX syndrome patients, while the second group consisted of patients with PEG and the third group involved patients with no additional systemic diseases, other than the diagnosis of cataract as control. Total oxidative stress (TOS), total antioxidant capacity (TAC), PON, and ARE levels in aqueous humor and serum were measured. RESULTS: TAC, PON and arylesterase levels in aqueous humor and serum of the PEX syndrome and PEG patients were significantly decreased compared with control group (P<0.05). TOS values were higher in patients with PEX syndrome and PEG than controls (P< 0.05). TAC, PON and ARE levels of aqueous humor did not differ significantly between the PEX syndrome and PEG groups CONCLUSION: These findings are potentially of significance and add to the growing body of evidence for oxidative stress in PEX syndrome and PEG. Decreased antioxidant defense and increased oxidative stress system may play an important role in the pathogenesis of PEX syndrome and PEG.
Yag laser capsulotomy rates of 50 years and older individuals after use of the Zaraccom Ultraflex intraocular lenses
(DRUNPP-SARAJEVO, 2012) Toker, Mustafa Ilker; Ozec, Ayse Vural; Dursun, Ayhan; Yurdakul, Ismail; Erdogan, Haydar; Topalkara, Aysen; Arici, Mustafa Kemal
Aim: to evaluate the rate of symptomatic posterior capsule opacification requiring Nd:YAG capsulotomy in patients who underwent cataract extraction and implantation of zaraccom ultraflex lenses (one-piece hydrophobic acrylic square edged intraocular lens). Methods: 142 eyes of 103 patients who had cataract extraction and implantation of zaraccom ultraflex lenses (IOLs) were evaluated for rate of nd:yag capsulotomy from april 2008 to august 2009. The cases that received Nd:YAG capsulotomies were evaluated for visual acuity, lens position and centralization and the frequency of nd: yag laser determined. Results: the mean preoperative best corrected visual acuity (BCVA) was 0.31 +/- 0.20 And the final mean BCVA was 0.96 +/- 0.06 With snellen chart. The rate of nd: yag capsulotomy was 0.7%. The mean time to Nd: YAG capsulotomy was 24.34 Months (range: 12 to 30 months). Conclusion: posterior capsule opacification was significantly less for the patients 50 years and over with the Zaraccom Ultraflex IOLs at 2 years.

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