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Öğe A Bibliometric Analysis of Publications on Scabies(Ordu Üniversitesi, 2022) Tosun, MustafaObjective: Scabies is an ectoparasites caused by "Sarcoptes scabiei (S. scabiei) var. hominis" and can affect everyone regardless of gender, age and race. Scabies is caused by infestation with the ectoparasite S. scabiei var hominis and its incidence has increased in recent years. Bibliometric analysis uses a statistical method of academic literature in a certain research area. This study aimed to perform the bibliometric analysis of literature with scabies.Methods: All data of this study were included from the provided by Web of Science databases. It was used the keyword “scabies” for our study. All studies published between 1970 and December 2021 were included.Results: A total of 1924 publications were found. The most published fields were dermatology, general medicine, and infectious disease (31.20%, 10.92%, and 9.83%, respectively). The peak year of urticaria literature was 2019, with 5.85%. The United States was the most productive country, with 334 publications. Australia ranks second with 172 publications following the United States, while France takes third with 132 publications. Conclusion: This study analyzed the publications with scabies bibliometric analyses. It was determined that the most frequently discussed subjects were S. scabiei and treatment of scabies. This study can help the scientific community and policymakers to collaborate and discover possible treatments for scabies and prevent its spread.Öğe A Case of Psoriasis After Narrow Band UVB (NBUVB) Phototherapy for Vitiligo Treatment(Ümit Muhammet KOÇYİĞİT, 2021) Tosun, Mustafa; Küçükosmanoğlu, İlknurPhototherapy methods commonly used in the treatment of vitiligo include narrow-band ultraviolet B (NB-UVB). A 23-years old male was diagnosed with vitiligo in the dermatology polyclinic and was followed up in the phototherapy unit with NB-UVB treatment of 3 sessions per week; in the 42nd session psoriasis plaques were seen to have developed. We suggest that this rare but important association should be considered as a side effect of narrow-band phototherapy.Öğe Analysis of corneal densitometry and endothelial morphometry in patients with psoriasis(Elsevier, 2021) Yeter, Duygu Yalinbas; Bozali, Erman; Apa, Anil Selim; Tosun, MustafaBackground: To evaluate corneal endothelial properties and corneal densitometry values in patients with psoriasis and to compare the results with those of healthy controls. Methods: This prospective, comparative, and cross-sectional study included 106 eyes of 53 patients who were diagnosed with psoriasis and 106 eyes of 53 age-gender matched healthy controls. All patients were evaluated in terms of ocular surface tests such as Schirmer-1 and tear break-up time (TBUT). Corneal endothelial measurements were performed using noncontact specular microscopy. Corneal tomographic and densitometric measurements were obtained using the Scheimpflug imaging system. Measurements were also evaluated according to the psoriasis area and severity index (PASI) score. Results: The mean TBUT and Schirmer 1 test values were significantly lower in the psoriasis group than in the healthy controls (p = 0.02, p < 0.001, respectively). While the mean endothelial cell density was significantly lower in patients with psoriasis than the healthy controls (2389.9 +/- 314.9 cells/mm2 vs. 2512.4 +/- 289.7 cells/ mm2, p = 0.02), the mean average endothelial cell area, standard deviation of cell area, coefficient of variation of cell area were significantly higher in patients with psoriasis (426.6 +/- 62.7 mu m2 vs. 403.2 +/- 46.1 mu m2, p = 0.01; 206.4 +/- 52.3 mu m2 vs. 183.2 +/- 43.8 mu m2, p = 0.006; and 48.1 +/- 6.3% vs. 45.7 +/- 6.7%, p = 0.04, respectively). Most of the densitometry measurements in concentric zones were higher in patients with psoriasis than in healthy controls, but none of the differences reached statistical significance. Conclusions: A regular eye examination is crucial in patients with psoriasis because corneal structural and functional changes, particularly endothelial alterations, are of utmost importance in planning intraocular surgeries in patients with psoriasis.Öğe Assessment by the Scheimpflug imaging system of corneal clarity and anterior segment properties in rosacea patients(Elsevier Science Inc, 2024) Bozali, Erman; Yeter, Duygu Yalinbas; Tosun, Mustafa; Apa, Anil SelimObjective: To evaluate the effects of rosacea on ocular surface changes such as alterations in dry eye parameters, corneal densitometry, and aberrations, in comparison with healthy controls. Methods: A total of 88 eyes of 44 patients diagnosed with rosacea and 88 eyes of 44 healthy controls were enrolled in this cross-sectional study. All participants underwent a comprehensive dermatologic and ophthalmic examination and Tear Break-Up Time (TBUT) and Schirmer-1 tests were performed. The rosacea subtype and Demodex count and OSDI scores of all participants were recorded. Corneal topographic, densitometric, and aberrometric measurements were obtained using the Scheimpflug imaging system. Results: The mean age of the 44 patients was 41.2 +/- 11.0 years of whom 31 (70.5%) were female. The mean TBUT and Schirmer-1 test values were significantly decreased and OSDI scores were significantly increased in the rosacea group compared to healthy controls (p < 0.01 for all). The most common subtype of rosacea was erythematotelangiectatic rosacea (70.4%). The severity grading of rosacea revealed that 18 (40.9%) patients had moderate erythema. The median (min-max) Demodex count was 14.0 (0-120) and the disease duration was 24.0 (5-360) months. The comparison of the corneal densitometry values revealed that the densitometry measurements in all concentric zones, especially in central and posterior zones were higher in rosacea patients. Corneal aberrometric values in the posterior surface were also lower in the rosacea group compared to healthy controls. The topographic anterior chamber values were significantly lower in the rosacea group.Öğe Bir deri yaşlanması modeli olarak Caenorhabditis elegans bireylerinde kalsinörin inhibisyonu ile ortaya çıkan değişiklikler(Cumhuriyet Üniversitesi, 2015) Tosun, Mustafa; Akyol, MelihSon yıllarda kalsiyum kanallarının deri yaşlanması üzerindeki rolüne dair bilgiler literatürde yer almaya başlamıştır. Kalsinörin inhibisyonunun Caenorhabditis elegans (C. elegans) bireylerinde yaşam süresini uzattığı bilinmektedir. C. elegans genlerinin önemli bir kısmı insan genlerine büyük benzerlik göstermektedir. Bu nematod doğal immunite, yara iyileşmesi ve deri yaşlanmasına yönelik çalışmalarda bir model olarak kullanılabilmektedir. Bu çalışmada kalsinörin inhibisyonunun C. elegans bireylerindeki yaşamsal fonksiyonlar üzerine olan etkilerinin değerlendirilmesi amaçlandı. Çalışma için bir kalsinörin inhibitörü olan siklosporin A'nın 1 ?M (1.doz), 0.1 ?M (2.doz), 0.01 ?M (3.doz) ve 0.001 ?M (4.doz) dozunda çözeltileri hazırlanarak her bir çözeltiden 1'er ml, içlerinde 10' ar ml Nematod Growth Media (NGM) bulunduran petrilere eklenmiştir. Homojenizasyonu sağlandıktan sonra NGM'ların soğutularak katılaşması sağlanmıştır. Kontrol grubu siklosporin eklenmemiş besiyerinde beslenmiştir. Senkronizasyonu yapılmış C. elegans'lardan siklosporinin belirtilen dozları ile hazırlanmış her bir petriye 20' şer adet aktarılmıştır. 6X–50X arasında büyütme sağlayan alttan ışıklandırmalı stereo mikroskop ile C. elegans'lar izlenmiştir. Bütün petrilerdeki C. elegans'lar ölene kadar her gün aynı saatte canlı hayvanlar sayılmış ve kontrol grubuyla karşılaştırılmıştır. Ayrıca C. elegans'ların fiziksel gelişimleri ve dakikadaki farinks pompalama sayıları da kontrol grubu ile karşılaştırılmalı olarak incelenmiştir. Çalışma sonucunda siklosporine maruz bırakılan C. elegans'ların kontrol grubuna göre yaşam sürelerinde doz artışına bağlı istatistiksel olarak anlamlı bir artış olduğu tespit edilmiştir (p<0,05). Siklosporine maruz bırakılan C. elegans'ların fiziksel gelişimlerinin doz artışına bağlı olarak anlamlı derecede azaldığı saptanmıştır (p<0,05). Siklosporin dozundaki artış farinks pompalama sayısında istatistiksel olarak anlamlı bir değişikliğe neden olmamıştır (p>0,05). Sonuç olarak kalsinörin inhibisyonu, C. elegans'ların gelişimsel sürecini yavaşlatır ve yaşam süresini uzatır. Kalsinörin inhibitörleri, benzer mekanizmalarla insanlarda deri yaşlanması üzerine olumlu etki yapabilir. Bu nedenle kalsinörin inhibisyonunun, deri yaşlanması üzerine etkinliğini ve etki mekanizmasını açıklayacak ileri çalışmalar gereklidir.Öğe Effect of Isotretinoin Treatment on the Inflammatory Markers in Patients with Acne Vulgaris: A Case-Control Study(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2024) Di?iş, Mahir; Tosun, Mustafa; Yasak Güner, Rukiye; Akyol, MelihObjective: Oral isotretinoin can affect inflammation markers in patients with acne vulgaris. This study aims to examine the impact of isotretinoin treatment on inflammatory markers in patients diagnosed with acne vulgaris. Material and Methods: Fifty-five patients diagnosed with moderate or severe acne vulgaris according to the Global Acne Grading Scale were included in this study. Patients were evaluated at regular intervals (at 0, 2nd, and 3rd months) during the treatment period. Complete blood count [including mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), plateletcrit, platelet distribution width (PDW), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW)], Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI), monocyte-high-density lipoprotein (HDL) ratio, monocyte-to-lymphocyte ratio (MLR), MPV/platelet ratio, and serum biochemistry panel were assessed during isotretinoin treatment. Additionally, the Acne Quality of Life Scale was used to assess patients' quality of life. Results: A significant increase in PLR and RDW levels was observed during isotretinoin treatment (p<0.05). However, SII, SIRI, AISI, monocyte/HDL ratio, NLR, PDW, MPV, sedimentation rate, and C-reactive protein levels did not show a significant change during isotretinoin treatment (p>0.05). Furthermore, this study demonstrated that oral isotretinoin treatment reduced the severity of acne and improved patients' quality of life. Conclusion: Isotretinoin may have inflammatory effects shown with PLR and RDW. However, other inflammatory markers did not show a significant change during isotretinoin treatment. Further comprehensive studies are needed to better understand the relationship between isotretinoin treatment and inflammatory markers. Copyright © 2024 by Türkiye Klinikleri.Öğe Effect of isotretinoin use on hematological parameters and biochemical values(Bayrakol Medical Publisher, 2022) Karagoz, Yalcun; Tosun, MustafaAim: The aim of this study was to investigate the general effects of oral isotretinoin on hematological parameters and biochemical values, and to identify whether these values vary according to age and gender. Material and Methods: The study included 143 patients diagnosed with moderate or severe acne in the age range of 15-47 years. Patients were monitored retrospectively. Hematological parameters and biochemical values were recorded before treatment, then at the end of the first and third months of the treatment. Results: The serum lipid levels, creatinine, cholesterol, triglyceride and AST values of liver enzymes, and renal function values were found to increase after the onset of treatment. Hematological parameters including LYM, HGB, HCT, RDW, MCV, PLT, MPV and PCT parameters were seen to increase after the onset of treatment, while the NEU parameter decreased. The values of other hematological parameters did not change. Discussion: Although the use of oral isotretinoin has been shown to cause changes in hematological parameters and serum lipid levels, liver and renal function values, these changes usually remain within normal limits and continue with treatment.Öğe Effects of psoriasis and metabolic syndrome on male sexual functions(Imr Press, 2021) Saygin, Huseyin; Tosun, Mustafa; Ozturk, Abuzer; Ergin, Ismail Emre; Kirac, Emre; Asdemir, Aydemir; Velibeyoglu, Arslan FatihBackground and Objective: Psoriasis is a chronic inflammatory systemic skin disease triggered by psychological, genetic and environmental factors. The effect of psoriasis on sexual health has not been fully elucidated. Coexistence of psychiatric disorders also affects negatively the life quality of psoriasis patients. This study investigates the relationship between the severity of the current illness, psychosocial health problems and coexisting metabolic syndrome on sexual health in male patients with psoriasis. Materials and methods: 52 male patients diagnosed with psoriasis and 50 healthy men included for the study. Patient groups Psoriasis Area Severity Index (PASI) and The Dermatology Life Quality Index (DLQI) were tested, subsequently International Index of Erectile Function (IIEF), Hamilton Rating Scale for Depression (HAM-D) tests and Metabolic syndrome (MetS) were reported for both groups. Eventually, the patient groups treaments were recorded. Results: IIEF, HAM-D scores and MetS were significantly different between the two groups (P = 0.017, P = 0.005, P = 0.009). IIEF score had a significant negative correlation with age, HAM-D and PASI scores (r = -0.405, -0.217 and -0.394, P = 0.028, 0.043 and 0.014). It is seen that the frequency and severity of ED increased with methotrexate treatment. Conclusion: It is showed that psoriasis has negative effects on male sexual health in this study. Our opinion of the reason is the natural course of the disease, its coexistence with diseases such as metabolic syndrome and depression, and the agents used in its treatment.Öğe Epidemiological characteristics of different types of adult acne in Turkey: a prospective, controlled, multicenter study(Dermatovenerological Soc Slovenia, 2023) Kutlu, Omer; Karadag, Ayse Serap; Demirseren, Dueriye Deniz; Iyidal, Ayseguel Yalcinkaya; Tosun, Mustafa; Kalkan, Goknur; Polat, MuallaIntroduction: Acne occurring in adults over the age of 25 years is known as acne tarda or adult acne. Three types of adult acne are recognized: persistent, late-onset, and recurrent acne. Most studies do not compare the characteristics between the three vari-ants. In addition, little is known about adult acne in males. This study describes the epidemiological factors of adult acne and investigates certain triggering factors by sex and different types of adult acne. Methods: A multicenter, prospective, descriptive study was conducted. Patients with adult acne and an acne-free control group were compared regarding medical history, family history, smoking and drinking habits, and dietary factors. In addition, triggering and prognostic factors were investigated by sex and three different types of acne: persistent, late-onset, and recurrent acne. Results: The participants included 944 (88.56%) female and 122 (11.44%) male patients with adult acne, and 709 (73.85%) female and 251 (26.15%) male control patients. The consumption of crackers, chocolate, and pasta was significantly more common in the acne group than in the control group (p = 0.017, 0.002, and 0.040, respectively). Male patients with adult acne had a significantly longer disease duration than female patients with adult acne (p = 0.024). The most common type of acne was recurrent acne, followed by persistent and late-onset acne. Among patients with persistent acne, 14.5% had polycystic ovary syndrome (PCOS), whereas 12.2% of patients with recurrent acne and 11.1% of patients with late-onset acne had PCOS. Severe acne was more com-mon in the persistent acne type (28.13%). The cheek (59.90%) was the most common involvement area, and stress (55.23%) was the most common triggering factor regardless of sex. Conclusions: Although adult female and male patents with adult acne share similar triggering factors, the involvement areas can differ, which may indicate the additional hormonal etiology of female adult acne. Further epidemiological studies on adult acne in both sexes may illuminate the pathogenesis of the disease, thus making possible the development of new treatment strategies.Öğe Evaluation of cardiovascular risk in people with rosacea: A prospective study(2022) Dirim, Yusuf Cihan; Güner, Rukiye Yasak; Tosun, Mustafa; Akyol, Melih; Turgut, İsmailSystemic inflammation is accepted as a nontraditional cardiovascular risk factor and has been shown to play a role in all stages of atherosclerosis. Rosacea is a chronic inflammatory\rskin disease. In our study, we aimed to evaluate the cardiovascular risk in rosacea patients. 40 people with rosacea (30 women, 10 men) and a control group of\r40 age- and sex-matched individuals (28 women, 12 men) who had no chronic inflammatory skin disease were included in the study. Participants' body mass index (BMI)\rwas calculated and their blood pressure was measured. Fasting blood glucose, fasting blood insulin, lipid profile, hemogram, basic biochemical parameters, erythrocyte\rsedimentation rate, and C-reactive protein levels were analyzed after at least 8 hours of fasting. In all participants, carotid intima-media thickness (CIMT) was measured\rusing high-resolution B-mode ultrasonography (with a 4 MHz linear transducer. The mean CIMT values were 0.62 (0.18) mm in the rosacea group and 0.50 (0.14) mm in\rthe control group. Statistical comparison indicated that mean CIMT was significantly greater in the patients with rosacea compared to the control group (p=0.001). There\rwas no significant difference between the rosacea and control groups in terms of mean height, weight, BMI, or systolic and diastolic blood pressures (p>0.05). People with\rrosacea should be monitored periodically in terms of cardiovascular disease risk.Öğe Evaluation of health literacy and drug use attitudes and behaviors of patients admitting to dermatology clinic(Sivas Cumhuriyet University, 2021) Yasak Güner, Rukiye; Tosun, Mustafa; Akyol, Melih; Hayta, Sibel Berksoy; Özpınar, SalihaObjective: In the present study, the purpose was to investigate the relationship between health literacy levels and drug use attitudes and behaviors of patients admitting to dermatology outpatient clinics.Method: A total of 295 volunteers admitting to Sivas Cumhuriyet University Dermatology Clinic between 1/03/2020 and 31/12/2020 were included in the study. Two forms were used to collect the data in the study. These were the Data Collection Form and the Health Literacy Scale.Results: The mean age of the participants was 33.0 ±16.36; and 62.0% of them were women. The mean score of the participants in Health Literacy Scale was 4.60±0.2; and it can be argued that the health literacy levels of the participants were high. The relations between health literacy and dermatological drug use attitudes and behaviors were evaluated with the Correlation Analysis; and a significant relation was detected between the two variables (p<0.05).Conclusions: Dermatology patients have high health literacy and their dermatological drug use attitudes and behaviors are at adequate levels.Öğe Mediating effect of disease severity on the relationship between smoking status and quality of life in psoriasis patients(Cukurova Univ, Fac Medicine, 2022) Tosun, Mustafa; Ilgun, Gulnur; Tosun, NurperihanPurpose: The aim of this study was to examine the relationship between smoking and quality of life and to investigate the mediating role of disease severity on this relationship in psoriasis patients. Materials and Methods: In the study, 268 psoriasis patients were reached by the convenience sampling method. In the study, patients' quality of life was measured with dermatology quality of life index (DLQI) and disease severity was measured with psoriasis area and severity index (PASI). The effect of the independent variable (smoking) on the dependent variable (quality of life), both directly and indirectly through the mediating variable (disease severity), was examined by process analysis. Results: Smoking status shows statistically significant differences according to gender, age, marital status, occupation, and income groups. 17.02% of women and 44.09% of men smoke. 19.74% of single and 33.85% of married smoke. 20% of unemployed and 39.13% of employees smoke. 17.76% of low-income, 50.91% of middle-income, and 40.98% of high-income people smoke. This cross-sectional study revealed that smoking in psoriasis has no direct effect on the quality of life, but that smoking has a full indirect effect on the quality of life through disease severity. Conclusion: In the study, it was found that smoking negatively affects the quality of life through both disease severity. Accordingly, it is recommended that patients be informed about the effect of smoking on their diseases.Öğe Pulmonary physician consultancy in emergency services in Turkey (PUPCEST) - a prospective multicenter study(EUROPEAN RESPIRATORY SOC JOURNALS LTD, 2018) Diken, Ozlem Ercen; Ekici, Aydanur; Bektas, Hayriye; Yildiz, Hanifi; Tabaru, Ali; Ogan, Nalan; Gulhan, Pinar Yildiz; Ozdemir, Tarkan; Arslan, Sulhattin; Tosun, Mustafa; Baslilar, Seyma; Kilic, Talat; Ozkisa, Tuncer; Ozyurt, Sibel Pekcan; Dikis, Ozlem Sengoren; Arpag, Huseyin; Erbay, Umran Toru; Tutar, Umit; Ayvaci, Aysun; Esendagli, Dorina; Hocanli, Iclal; Oktay, Nuray; Ozcelik, Neslihan; Karadag, Mehmet; Kirkil, Gamze; Ozlu, Tevfik…Öğe Rasch Analysis of the Dermatology Life Quality Index in Turkish Psoriasis Patients: Validation Study(Ortadogu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2024) Tosun, Mustafa; Yasak Güner, Rukiye; Çam, Selim; Dırım, Yusuf Cihan; Bülbül Başkan, Emel; Akyol, MelihObjective: The Dermatology Life Quality Index (DLQI) is a widely used quality of life scale in many dermatological diseases such as psoriasis. Recently, there have been discussions about the inadequacy of DLQI in the evaluation of dermatological diseases. This study aimed to examine the psychometric properties of the DLQI scale, in a sample of Turkish psoriatic patients. Material and Methods: A total of 979 psoriasis patients, 509 male (52.4%) and 470 female (47.6%), who filled out the DLQI questionnaire between April 2013 and January 2019, were included in the study. This was a retrospective study conducted. Data were analyzed using the Rasch model to obtain meaningful scores for the DLQI. Results: According to the Rasch analysis, the measurement ability of the ninth question was found to be insufficient in general. It has been determined that DLQI scale items can vary in measuring ability according to age, gender and marital status are insufficient. In addition, it was found that the assumption that the answers in Likert-type expressions in the DLQI scale are equidistant from each other is not correct. Conclusion: DLQI seems to have a poor fit with the Rasch model for Turkish psoriasis patients. In addition, DLQI may vary according to age, gender and marital status. Therefore, it is recommended to develop new scales in the evaluation of psoriasis patients. © 2024 by Türkiye Klinikleri.Öğe Relationship of interoceptive accuracy in acne vulgaris patients: A prospective, controlled study(Springer, 2024) Alagoz, Elif Nur; Tosun, Mustafa; Guner, Rukiye Yasak; Akyol, MelihAcne vulgaris (AV) is a chronic inflammatory skin condition predominantly observed during adolescence. Interoception accuracy (IAc) refers to the ability to perceive internal bodily states such as hunger and thirst. Since the brain and skin originate from the same embryological layer, the ectoderm, it is hypothesized that skin changes and disorders might affect individual perceptions. The purpose of this study is to evaluate the relationship between IAc and AV. This study included 94 AV patients and 94 sex- and age-matched healthy controls. The participants completed the Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Dermatology Life Quality Index (DLQI), and heartbeat perception task to assess IAc. The severity of acne was assessed using the Global Acne Grading System (GAGS). Acne patients had lower IAc scores than controls did (P = 0.026). Severe depression or anxiety symptoms were associated with lower IAc scores (P = 0.027, P = 0.046). Acne severity did not significantly affect IAc scores. There was a weak negative connection between the DLQI score and IAc (r = -0.208, P = 0.022), suggesting that lower quality of life is correlated with reduced IAc. Gender significantly influenced IAc. As a result, individuals with acne may have a reduced capacity to accurately perceive internal bodily states, potentially impacting overall well-being. Enhancing interoception might positively contribute to AV treatment and management.Öğe Rosacea disease and Demodex spp. relationship; Retrospective study(2018) Özpınar, Necati; Tosun, MustafaRosacea.Method: In our study, the patient group who visited Sivas Numune Hospital Dermatology Outpatient Clinic betweenJanuary 01, 2018 and September 25, 2018, and was diagnosed with Rosacea was observed with respect toDemodexspp.Samples were taken from 338 patients with the procedure of Standardized Skin Surface Biopsy (SSSB).Results: The presence of Demodex spp. was found to be positive in 166 (49.1 percent) of 338 rosacea patients. Whenthe patients are evaluated based on gender, 17 (28.9 percent) of 59 male patients and 136 (48.7 percent) of 279 femalepatients were detected to have Demodex spp.and this difference was statistically significant (Table 1). Positivity ofDemodex spp. based on gender was deemed statistically significant (p<0.05).As a result of the analysis by gendergroups, Demodexspp. was identified in 13 (23.6 percent) of 55 rosacea patients under the age of 20 years, 75 (48.7percent) of 154 patients between the age of 20 and 40 years and 78 (60.4 percent) of 129 patients over the age of 40yearsand the difference between groups was statistically significant (p<0.05, Table 2). Positivity of Demodex spp.basedon age groups was found statistically significant (p<0.05).Conclusions: It was surmised that Demodex spp. plays an important role in aetiopathogenesis of rosacea disease, thisparasite should be considered during the treatment planning of the disease and rosacea patients should be investigated interms of Demodex spp.Öğe Rosacea-Specific Quality of Life Scale (RosaQoL): The Study of Adaptation and Validation for Turkish Rosacea Patients(Marmara Univ, Inst Health Sciences, 2022) Tosun, Mustafa; Karagoz, YalcinObjective: Rosacea-Specific Quality of Life Scale (RosaQoL) developed specifically for rosacea. The aim of the study was to adapt the RosaQoL Scale that is specific to Rosacea used in evaluating the quality of life of patients with Rosacea into Turkish, and evaluate its validity and reliability. Methods: The RosaQoL Scale is a 21-item index that is specific to Rosacea, and was developed originally in English. The Turkish Scale, which was created after the clinical examinations of the patients, was applied to the patients. A total of 285 people, 240 females (84.2%) and 45 males (15.8%), who were diagnosed with Rosacea, admitting to the dermatology clinic between May 2019 and August 2019 were included in the study. Results: The mean age of the patients was found to be 44.8 +/- 12.5 years in the study. The internal consistency of the scale (Cronbach's Alpha Coefficient) was found to be 0.952. The correlation coefficient was calculated as r=0.988 in the test-retest reliability. The total RosaQoL score was 62.4 +/- 11.5 (Mean +/- SD), and the total DLQI score was 7.85 +/- 5.04 (Mean +/- SD). For validity analysis, the correlation coefficient between RosaQoL and DLQI was calculated as r=0.411 (p<0.05). Conclusion: The Turkish version of the RosaQoL was valid and reliable for evaluating the quality of life of Turkish Rosacea patients.Öğe Rosacea’ya özgü yaşam kalitesi ölçeği (ROSAQOI): Türkçe geçerlilik ve güvenilirlik çalışması(Sivas Cumhuriyet Üniversitesi, 2021) Tosun, Mustafa; Karagöz, YalçınBu araştırmanın amacı, rosacealı hastaların yaşam kalitesinin değerlendirilmesinde kullanılan rosaceaya özgü yaşam kalitesi (RosaQoL) ölçeğinin Türkçe'ye uyarlanması, geçerlilik ve güvenilirliğinin değerlendirilmesidir. Ülkemizde rosaceaya özgü bir ölçek bulunmamaktadır. Geçerlilik ve güvenilirliği yapılarak bu ölçeğin ülkemize kazandırılması amaçlandı. Anket uygun çeviri basamaklarını takip ederek Türkçe'ye çevrildi. Çalışmaya 18 yaş üstü, okuma-yazma bilen, aktif psikiyatrik hastalığı olmayan hastalar alındı. Hastaların sosyodemografik bilgileri kaydedildi ve klinik muayeneleri yapıldıktan sonra oluşturulan Türkçe ölçek hastalara uygulandı. Ölçeğin güvenilirliği test-tekrar test ve iç tutarlılık analizi ile belirlendi. Test-tekrar test güvenilirliği için, ölçek 30 hastada başlangıçta ve iki hafta sonra olmak üzere ikişer kez uygulandı. Test-tekrar test güvenilirliği, Pearson korelasyon testi ile istatistiksel olarak değerlendirildi. İç tutarlığın tahmini olarak Cronbach alfa katsayısı hesaplandı. Ölçeğin yapı geçerliliğinin değerlendirilmesi açıklayıcı faktör analizi yapıldı. Çalışmaya, Sivas Numune Hastanesi Dermatoloji polikliniğine Mayıs 2019- Ağustos 2019 tarihleri arasında başvuran, rosacea tanısı almış 240 kadın (%84,2) ve 45 erkek (%15,8) olmak üzere toplam 285 kişi alınmıştır. Çalışmaya alınan hastaların yaşları 21-72 arasındadır. Hastaların yaş ortalaması 44,86 ± 12,50 olarak bulunmuştur. Test-tekrar test güvenilirliğinde korelasyon katsayısı r=0,856 olarak hesaplandı. İç tutarlılık analizinin ölçümünde Cronbach-alfa katsayısı 0,952 olarak bulunmuştur. Geçerlilik analizi için açıklayıcı faktör analizi yapılmış ve ölçeğin 21 maddeden ve 3 boyuttan oluştuğu görülmüştür. Özdeğerlerin açıkladıkları birikimli varyans miktarı, toplam varyansın 72,129'dur. Bu değer oldukça yüksektir. En iyi alt sınır olarak kabul edilen % 60 değerini çok geçmiştir. Sonuç olarak; elde edilen RosQoL ölçeği'nin türkçe versiyonunun geçerliği ve güvenilirliği sağlanmış olup, rosacealı hastaların yaşam kalitesinin değerlendirilmesinde geçerli ve güvenilir bir ölçek olarak kullanılabilir.Öğe Skin manifestations following anti-COVID-19 vaccination: A multicentricstudy from Turkey(Wiley, 2023) Topal, Ilteris Oguz; Tokmak, Asli; Kurmus, Gokce Isil; Kalkan, Goknur; Demirseren, Duriye Deniz; Tosun, Mustafa; Emre, SelmaPurposeAfter the emergence of the pandemic caused by the COVID-19 virus, vaccination with various vaccines has started to be implemented across the world. To identify dermatological reactions developing after the COVID-19 vaccines administered in Turkey and determine their clinical features and risk factors that may play a role in their development. Materials and MethodsThe study included patients aged >= 18 years, who presented to 13 different dermatology clinics in Turkey between July 2021 and September 2021 after developing dermatological reactions following the administration of the COVID-19 vaccine. After providing written consent, the patients were asked to complete a standard survey including questions related to age, gender, occupation, comorbidities, the regular medication used, the onset of cutaneous reactions after vaccination, and localization of reactions. Dermatological reactions were categorized according to whether they developed after the first or second dose of the vaccine or whether they occurred after the inactivated or messenger RNA (mRNA) vaccine. The relationship between dermatological reactions and some variables such as gender and comorbidities was also evaluated. ResultsA total of 269 patients [116 women (43.1%), 153 men (56.9%)] were included in the study. It was observed that the dermatological diseases and reactions that most frequently developed after vaccination were urticaria (25.7%), herpes zoster (24.9%), maculopapular eruption (12.3%), and pityriasis rosea (4.5%). The rate of dermatological reactions was 60.6% after the administration of the mRNA vaccine and 39.4% after that of the inactivated vaccine. There was a statistically significantly higher number of reactions among the patients that received the mRNA vaccine (p = 0.001). ConclusionThe most common reactions in our sample were urticaria, herpes zoster, and maculopapular eruption. Physicians should know the dermatological side effects of COVID-19 vaccines and their clinical features.Öğe Telangiectasia macularis multiplex acquisita: A new entity and literature review(Galenos Publ House, 2025) Zekey, Emre; Tosun, Mustafa; Guner, Rukiye Yasak; Akyol, Melih; Kaya, SeyhmusTelangiectasia macularis multiplex acquisita (TMMA) is a very rare entity that has been reported in the Asian population to date. Associations with hepatitis infection and several other systemic diseases have been reported. Its association with hepatitis C infection is a newly designated entity. Here, a 42-year-old Turkish patient with hepatitis C infection who was diagnosed with TMMA is presented, and a literature review is given. Recognition of the characteristic presentation of this rare disease will facilitate the clinician's diagnosis and approach.
