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Öğe THE ASSOCIATION BETWEEN PLASMA D-DIMER LEVELS AND COMMUNITY-ACQUIRED PNEUMONIA(HOSPITAL CLINICAS, UNIV SAO PAULO, 2010) Arslan, Sulhattin; Ugurlu, Serdal; Bulut, Gokten; Akkurt, IbrahimBACKGROUND: Plasma D-dimer levels are directly related to the intra- and extra-vascular coagulation that occurs in acute and chronic lung damage in patients with community-acquired pneumonia (CAP). OBJECTIVES: This study examines the relationship between the severity of community-acquired pneumonia and D-dimer levels. In addition, the study examines the correlations among community-acquired pneumonia, the radiological extent of the disease and mortality. METHODS: The Pneumonia Severity Index was used to classify patients into five groups. Patients were treated at home or in the hospital according to the guidelines for community-acquired pneumonia. Blood samples were taken from the antecubital vein with an injector and placed into citrated tubes. After they were centrifuged, the samples were evaluated with the quantitative latex method. RESULTS: The study included 60 patients who had been diagnosed with community-acquired pneumonia (mean age 62.5 +/- 11.7) and 24 healthy controls (mean age 59.63 +/- 6.63). The average plasma D-dimer levels were 337.3 +/- 195.1ng/mL in the outpatient treatment group, 691.0 +/- 180.5 in the inpatient treatment group, 1363.2 +/- 331.5 ng/mL in the intensive care treatment group and 161.3 +/- 38.1ng/mL in the control group (p<0.001). The mean D-dimer plasma level was 776.1 +/- 473.5ng/mL in patients with an accompanying disease and 494.2 +/- 280.1 ng/mL in patients without an accompanying disease (p<0.05). CONCLUSIONS: Plasma D-dimer levels were increased even in community-acquired pneumonia patients who did not have an accompanying disease that would normally cause such an increase.Öğe Differences in the body composition and biochemistry in women grouped as normal-weight, overweight and obese according to body mass index and their relation with cardiometabolic risk(VERSITA, 2010) Ozenoglu, Aliye; Ugurlu, Serdal; Can, Gunay; Sarkis, Cihat; Demirel, YeltekinMorbidity of obesity-related diseases tends to increase due to a rise in the body mass index (BMI). We aimed to investigate how the body composition and biochemical parameters change while BMI increases in adult women were categorized as so: as normal weight, overweight and obese. Our objectives are to study the effects of those changes in the development of metabolic disturbances and to find out which parameters are the most sensitive to predict cardiometabolic risks. Three hundred and twenty two records of adult women (mean age: 38.62 +/- 12.71 year) who admitted to our unit concerning about losing or preserving their weights, were analyzed in the study. All patients had undergone anthropometric measurements and body composition analyses as well as some biochemical tests. Body composition analyses were performed by means of the Bioelectrical Impedance Analyzer (BIA). Increase in BMI significantly increased the body fat, blood sugar, insulin, triglyceride and uric acid levels. BMI and circumference of the waist were significantly and negatively correlated with the ratio of body water and lean mass/fat mass. However they were positively correlated with the ratio of fat mass and basal metabolism. Furthermore, it was also found that BMI and circumference of the waist were significantly and positively correlated with level of fasting blood sugar, insulin, triglyceride, homeostasis model assessment insulin resistance (HOMA-IR), uric acid and fibrinogen levels, and negatively correlated with high density lipoprotein (HDL) cholesterol level. In multiple regression analyses, circumference of waist measurements was significantly correlated with insulin, triglyseride and HDL, whereas the correlation between BMI and these parameters was not found significant. Total body fat mass (as %) showed significant correlation only with HDL-C level. It could be said that obesity which is a disorder that causes many health complications and affects the quality of life in the short and long term could be prevented or cured by keeping negative environmental conditions under control. According to our results, visceral adipose tissue (VAT) measurement was thought to be more related for metabolic and cardiovascular disorders rather than BMI. We also propose to test fasting blood glucose, insulin, triglyceride, HDL, fibrinogen, homocystein (HOM) levels along with VAT measurements to predict more truly about not only global cardiometabolic risk but also dementia in later life.Öğe DO Carriers of A MEFV Mutation Have Any Selective Advantage to A Pathogen Endemic In the Same Geography?(Wiley, 2011) Ugurlu, Serdal; Engin, Aynur; Hatemi, Gulen; Ozgon, Gulay; Akyayla, Elif; Bakir, Mehmet; Ozdogan, Huri[Abstract Not Available]Öğe DOES CARRIERSHIP FOR FMF-ASSOCIATED MUTATIONS OFFER ANY ADVANTAGE IN CRIMEAN-CONGO HAEMORRHAGIC FEVER?(Oxford Univ Press, 2011) Ugurlu, Serdal; Engin, Aynur; Ozgon, Gulay; Hatemi, Gulen; Akyayla, Elif; Bakir, Mehmet; Ozdogan, Huri[Abstract Not Available]Öğe FAMILIAL MEDITERRANEAN FEVER AND MULTIPLE SCLEROSIS: A CASE REPORT(MEDFARMA-EDICOES MEDICAS, LDA, 2009) Ugurlu, Serdal; Bolayir, Ertugrul; Candan, Ferhan; Gumus, CesurA 30-year old man diagnosed with Familial Mediterranean fever (FMF) 2.5 years ago presented with numbness in his left lower extremity and ataxia. Multiple sclerosis (MS) plaques were founded in his spinal and cranial MRI. The diagnosis of MS was established and steroid treatment was started. FMF and MS coexistence is rare, but should not be missed.Öğe FOUR NOVEL MEFV GENE MUTATIONS IN A POPULATION WHERE THE PREVALENCE OF CRIMEAN-CONGO HEMORRHAGIC FEVER AND MEFV GENE CARRIER STATUS IS VERY HIGH(Oxford Univ Press, 2011) Ozgon, Gulay; Engin, Aynur; Hatemi, Gulen; Akyayla, Elif; Ugurlu, Serdal; Bakir, Mehmet; Ozdogan, Huri[Abstract Not Available]Öğe Four Novel MEFV Gene Mutations in a Population Where the Prevalence of Crimean-Congo Hemorrhagic Fever and MEFV Gene Carrier Status Is Very High(Wiley, 2011) Ozgon, Gulay; Engin, Aynur; Hatemi, Gulen; Ugurlu, Serdal; Akyayla, Elif; Bakir, Mehmet; Ozdogan, Huri[Abstract Not Available]Öğe IN A FAMILIAL MEDITERRANEAN FEVER PREVALENT REGION, ARE FAMILIAL MEDITERRANEAN FEVER AND BEHCET'S DISEASE ASSOCIATED?(BMJ PUBLISHING GROUP, 2019) Alparslan, Ozgur; Egeli, Bugra Han; Demirel, Yeltekin; Ugurlu, Serdal…Öğe Intimamedia thickening in patients with familial Mediterranean fever(OXFORD UNIV PRESS, 2009) Ugurlu, Serdal; Seyahi, Emire; Cetinkaya, Frat; Ozbakr, Fatma; Balci, Huriye; Ozdogan, HuriMethods. We studied 100 (46 males, 54 females; mean age: 40 6 years) patients with FMF. Also 94 (15 males, 79 females; mean age: 41 7 years) patients with SLE and 103 (44 males, 59 females; mean age: 40 5 years) apparently healthy volunteers were included as the control groups. Subclinical atherosclerosis was assessed by investigating atherosclerotic plaques and measuring IMT from carotid and common femoral arteries using B-mode ultrasonography (USG). Traditional atherosclerotic risk factors were also assessed. Results. Both FMF and SLE patients had significantly higher carotid (C-IMT) and femoral artery IMT (F-IMT) compared with healthy controls. This was also true after adjustment for atherosclerotic risk factors. Only patients with SLE were found to have higher frequency of atherosclerotic plaques in the carotid and in the carotid and/or femoral artery. When all atherosclerotic risk factors were adjusted, again only patients with SLE were found to have risk for atherosclerotic plaques. In FMF, whereas the presence of atherosclerotic plaques was only associated significantly with diabetes mellitus; C-IMT was correlated with age, BMI and fasting glucose; and F-IMT with age and BMI. Conclusions. Increased atherosclerosis defined as the presence of plaques was not observed in patients with FMF. The significance of increased C- and F-IMT among patients with FMF must be further assessed.Öğe Large vessel involvement in Behcet's syndrome: A retrospective survery(WILEY-LISS, 2008) Melikoglu, Melike; Ugurlu, Serdal; Tascilar, Koray; Caglar, Erkan; Seyahi, Emire; Hamuryudan, Vedat; Yurdakul, Sebahattin; Yazici, Hasan…Öğe LIVER DISEASES IN PREGNANCY(Galenos Yayincilik, 2008) Sarkis, Cihat; Imir, Gonca; Ugurlu, Serdal; Caglar, Erkan; Yanik, AliLiver disease in pregnancy is rare and it is associated with the high maternal and neonatal mortality rate. Some of the liver diseases are specific for pregnancy. The most common liver diseases in pregnancy are Acute fatty liver of pregnancy, Intrahepatic cholestasis of pregnancy, HELLP syndrome, liver dysfunction due to preeclampsia, hyperemesis gravidarum, Hepatitis E of pregnancy, and other Hepatitis infections, and Budd-Chiari syndrome. In this review, incidence, risk factors, pathogenesis, clinical presentation, diagnosis, treatment and outcome of those liver diseases unique to pregnancy are discussed through the literature.Öğe METABOLIC DISTURBANCES ARISING OUT OF PSYCHIATRIC PHARMACOTHERAPIES AND THE IMPORTANCE OF DIETETIC INTERVENTION IN ITS TREATMENT(NOBEL ILAC, 2009) Ozenoglu, Aliye; Ugurlu, Serdal; Can, Guenay; Eker, Engin; Elmacioglu, FundaObjective: The aim of this study was to compare alterations at body weight, composition and blood biochemistry in adult patients (age: 40.54+/-12.82 years) taking pharmacotherapy for their psychiatric disorders and adults (age: 38.61+/-12.70 years) who were not taking psychiatric treatments. Material and Method: A total of 128 (111 female, 17 male) patients in study group, and 347 (312 female, 35 male) who didn't have any endocrinologic-metabolic or psychiatric disorders and were not on any drug treatment in control group were evaluated. At the beginning, antropometric measuremnts, body composition analysis with a bioelectrical impedance analyzer and blood samples for some biochemical tests (Fasting blood glucose, insulin, HbA1C, triglyceride, total cholesterol, HDL, LDL blood counting, vitamin B12, folate, zinc, CRP, homocystein, cortisol,fibrinogen, TSH, uric acid levels) were taken for all patients. Results were analyzed statistically by using a computer program SPSS for Windows 10.0 with Mann Whitney U, pearson corelation, multipl regression analysis and Student t tests. Results: Mean treatment length with psychiatric drugs of the patients was 5.29+/-5.99 year, and mean weight gain at this period was 12.05+/-6.80 kg. Most of the patients have been taking more than one type of psychiatric drugs and their distrubition were 71.9% antidepressants, 31.3% anti-psychotics, 25.0% mood stabilyzers and 10.9% anxyolitics. Mean weight gain, body mass index (BMI), waist and hip circumferences, and body,fat percent of patients in study group were higher than in control group. Also while blood glucose, insulin, triglyceride, TSH,fibrinogen levels were statistically higher; total protein, albumin, zinc and folat levels were find statistically lower in study group. When all participants in both of the groups were divided as normal weight, owerweight and obese according to BA,11, it was found that while BMI increasing waist and hip circum-ferences, body fat percent, blood insulin, HbA1C levels increased but HDL levels decreased significantly. In study group, treatment period corelated positifly with body fat percent, blood insulin, TSH and homocystein levels; but corelated negatively with albumin level. Weight gain corelated positively with waist and hip circumfernces, body fat percent, blood insulin, trigliseride and TSH levels; but corelated negatively with folat level in patients taking psychiatric drugs. Conclusion: According to results of this study, it was shown that patients treated with psychiatric drugs are sensitive to metabolic and cardiovascular diseases along with obesity. So, it was though that patients who need psychiatric pharmacotherapies may have benefit if evaluated and treated by a team consisting endocrinologic, metabolic and nutritional specialists. A dietician knowledgeable and experienced in medical nutrition therapies on endocrine-metabolism and psychiatric disorders areas has an importantrole for collaborating with other related units.Öğe MUSHROOM POISONING: RETROSPECTIVE ANALYSIS OF 294 CASES(HOSPITAL CLINICAS, UNIV SAO PAULO, 2010) Eren, Sevki Hakan; Demirel, Yeltekin; Ugurlu, Serdal; Korkmaz, Ilhan; Aktas, Can; Kukul Guven, Fatma MutluOBJECTIVE: The objective of this study was to present special clinical and laboratory features of 294 cases of mushroom poisoning. MATERIALS AND METHODS: In this retrospective study, 294 patients admitted to the Pediatric and Adult Emergency, Internal Medicine and ICU Departments of Cumhuriyet University Hospital were investigated. RESULTS: Of 294 patients between the ages of 3 and 72 (28.97 +/- 19.32), 173 were female, 121 were male and 90 were under the age of 16 years. One hundred seventy-three patients (58.8%) had consumed the mushrooms in the early summer. The onset of mushroom toxicity symptoms was divided into early (within 6 h after ingestion) and delayed (6 h to 20 d). Two hundred eighty-eight patients (97.9%) and six (2.1%) patients had early and delayed toxicity symptoms, respectively. The onset of symptoms was within two hours for 101 patients (34.3%). The most common first-noticed symptoms were in the gastrointestinal system. The patients were discharged within one to ten days. Three patients suffering from poisoning caused by wild mushrooms died from fulminant hepatic failure. CONCLUSION: Education of the public about the consumption of mushrooms and education of health personnel working in health centers regarding early treatment and transfer to hospitals with appropriate facilities are important for decreasing the mortality.Öğe Nonalcoholic Fatty Liver Disease and Familial Mediterranean Fever: Are They Related?(SRPSKO LEKARSKO DRUSTVO, 2012) Sarkis, Cihat; Caglar, Erkan; Ugurlu, Serdal; Cetinkaya, Emel; Tekin, Nilufer; Arslan, Mubeccel; Ozdemir, Sebati; Tuncer, MuratIntroduction Familial Mediterranean fever (FMF) is a periodic febrile disease characterized by acute recurrent episodes of serositis. Liver disease is not considered a part of the spectrum of clinical manifestations of FMF. Objective The purpose of this study was to characterize the nonalcoholic fatty liver disease (NAFLD) that could be associated with familial Mediterranean fever (FMF). Methods Clinical findings and treatment information of the patients with FMF were obtained from outpatient files. Weight, height, hip and waist circumference, blood pressure, blood C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides (TG), creatinine, alanine aminotransferase (ALT), and insulin levels were determined in all subjects, and additionally liver ultrasonography was performed for signs of hepatosteatosis. Results Fifty-two age and gender matched patients with FMF, and 30 healthy controls were included in the study. The prevalence of metabolic syndrome in the patient group was determined to be significantly higher in the patient group compared to the healthy group. When FMF patients with and without hepatosteatosis were compared, the prevalence of metabolic syndrome was determined to be 6 vs. 3, respectively (p<0.001). Eleven patients with FMF were found to have grade 1-2 hepatosteatosis, and only 6 of healthy subjects had grade 1 hepatoseatosis (p=0.901). Conclusion When compared with healthy controls, we found the prevalence of NAFLD was not increased in patients with FMF.Öğe PREVALANCE OF ASTHMA AND ALLERGIC DISEASES IN MID-ANATOLIA(NOBEL ILAC, 2012) Arslan, Sulhattin; Ugurlu, Serdal; Demirel, Yeltekin; Can, GunayObjective: Allergic diseases are commonly seen in childhood. In this study the prevalences of asthma and other allergic diseases were investigated among the school children in Sivas in the year 2008. Material and Method: The questionnaire was based on the "International Study of Asthma and Allergies in Childhood (ISAAC)" questionnaires. If children were younger than 12 years the questionnaire was distributed to children by their teachers at school and was filled out by their parents. Results: Mean age of 1947 children was 10.28 +/- 2.24 (7-16), 50.9%of them were girls and 49.1%were boys. lifetime wheezing rate was 26.8%, physician-diagnosed asthma was 10.1%, allergic rhinitis was 25.2%, and allergic dermatitis was %28.3. The asthmatic subjects also reported the symptoms of allergic rhinitis (4.7%), conjunctivitis (4.2%) and dermatitis (4.3%). Conclusion: We determined the prevalence of asthma and other allergic disease of primary school children between ages of 7-15 in Sivas. One should bare in mind that one or more allergic diseases such as rhinitis, dermatitis and conjunctivitis may be observed in a student with asthma depending on the relationship between those diseases.Öğe PREVALENCE OF FMF AND CHRONIC RENAL FAILURE DUE TO AMYLOIDOSIS AND FREQUENCY OF MEFV MUTATIONS IN ZARA, TURKEY(OXFORD UNIV PRESS, 2011) Ozdogan, Huri; Ugurlu, Serdal; Hatemi, Gulen; Demirel, Yeltekin; Calli, Sanda; Ozgon, Gulay; Yildirim, Suleyman; Batumlu, Mine; Cevirgen, Dilsen; Akyayla, Elif; Celik, Selda; Masatlioglu, Seval; Ozguler, Yesim; Cengiz, Mahir; Kilic, Hasan; Alpaslan, Ozgur; Balli, Mustafa…Öğe Serum Levels of Mannan-Binding Lectin in Patients with Crimean-Congo Hemorrhagic Fever(MARY ANN LIEBERT, INC, 2010) Engin, Aynur; Ugurlu, Serdal; Caglar, Erkan; Oztop, Atifet Yasemin; Inan, Dursun; Elaldi, Nazif; Dokmetas, Ilyas; Bakir, MehmetObjective: Mannan-binding lectin (MBL) is a central component of the innate immune response. Genetic variations in the MBL gene that reduce circulating levels and alter functional properties of the MBL are associated with susceptibility for many infectious diseases. Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by an arbovirus in the family Bunyaviridae. We have investigated serum MBL levels in CCHF patients and a possible association between circulating MBL concentrations and the severity of CCHF. Materials and Methods: Forty-seven patients found to have CCHF in Cumhuriyet University Hospital and 29 healthy controls were recruited for this study. There were no differences in terms of age and sex between the patients and the healthy controls (p = 0.64 and p = 0.484, respectively). This study was conducted between July 1 and August 31, 2007, in Cumhuriyet University Hospital in Sivas, a city located in the central Anatolian region of Turkey. Patients with CCHF were matched with healthy controls, and serum MBL levels were measured. Results: The median serum MBL level was significantly lower in the patient group than in the healthy control group (48.0 ng/mL [inter-quartile range (QR) 30.4-128.0] and 212.0 ng/mL [IQR: 115.8-524.0], respectively; p < 0.001). No significant difference was found between serum MBL levels in CCHF patients with severe and nonsevere form of the disease (p = 0.167). Conclusion: MBL levels were significantly lower in patients with CCHF than in healthy controls. There was no meaningful correlation between the serum MBL level and severity of CCHF disease. Low serum MBL level may be associated with the high consumption of MBL in CCHF infection and/or MBL gene polymorphism.Öğe Subclinical atherosclerosis in familial Mediterranean fever(WILEY-LISS, 2008) Ugurlu, Serdal; Seyahi, Emire; Cetinkaya, Firat; Ozbakir, Fatma; Balci, Huriye; Ozdogan, Huri…Öğe The Prevalence of Familial Mediterranean Fever and Behcet's Disease: A Cross-Sectional Study(Turkish League Against Rheumatism, 2020) Alparslan, Ozgur; Egeli, Bugra Han; Demirel, Yeltekin; Ugurlu, SerdalObjectives: This study aims to investigate the coexistence of familial Mediterranean fever (FMF) and Behcet's disease (BD). Patients and methods: This cross-sectional study was conducted between May 2009 and August 2009. The study included 14,881 randomized children (7,741 males, 7,140 females; mean age 13.0 years; range, 12 to 14 years) from sixth to eighth grades, in 72 primary schools in the center of Turkey's Sivas province. Of these children, 985 were randomly selected and interviewed with their parents. During these interviews, the family trees up to second-degree relatives were drawn. The presence of a diagnosis of FMF or BD was questioned. Patient history, physical examination, eye examination, and pathergy test were performed when needed. The methods of this study were reported in accordance with the STrengthening the Reporting of OBservational studies in Epidemiology guidelines. Results: Nine hundred and eighty-five students, 978 mothers, 953 fathers, and 1,876 relatives (4,792 in total) were included in the study. The ratio of consanguineous marriage ratio was 13.6%. Only 30 patients (0.6%) were diagnosed with FMF, while three (0.06%) were diagnosed with BD. In patients with FMF, consanguineous marriage was statistically significant (p=0.015). In terms of low back, heel, and joint pain and morning stiffness, there was a statistically significant difference between patients with and without FMF (p<0.05). Of the three BD patients, one had concomitant FMF. Conclusion: The prevalence of FMF in Sivas province was higher than Turkey's prevalence; however, the prevalence of BD was lower. According to these findings, it is not easy to conclude that the two diseases share a common pathogenesis.Öğe The Reference Values of Body Composition for Adult Females Who are Classified as Normal Weight, Overweight or Obese Accoding to Body Mass Index(Medi+World Int, 2008) Ozenoglu, Aliye; Ugurlu, Serdal; Can, Gunay; Hatemi, HusrevObjective: The aim of this study was to conduct the reference values for body composition measured with Bioelectrical Impedance Analyser (BIA) of adult females without any endocrinologic and/or metabolic disturbances, according to their body mass index (BMI) and grouped as normal, overweight, obese and morbidly obese. Patients and Methods: A total of 327 female subjects were taken into the study. Their body compositions were measured with BIA, in addition to measurement of their weight, height, and waist and hip circumferences. Results were statistically analysed with ANOVA test. Results: As BMI got higher, percentages of body fat and basal metabolism (BM) increased significantly; but percentages of body water and fat free mass, and lean/fat ratio showed a significant decrease. In addition, waist and hip ratios, percentage of body fat and BM showed a significant positive corelation with BMI. Conclusion: We concluded that our results could be used as reference values for studies on body composition, especially to predict the degree of body fatness of obese patients and also nutritional status of patients who need nutritional supports.
