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    Asymmetric dimethylarginine and M30 concentrations in heart failure
    (DERMAN MEDICAL PUBL, 2017) Dogan, Halef Okan; Beton, Osman; Ulger, Dilara; Ersan, Serpil; Bakir, Deniz
    Aim: Apoptosis has been implicated in the development of various cardiovascular diseases. Caspase-cleaved cytokeratin 18 (M30) is released during apoptotic cell death. The concentrations of M30 and the correlation with asymmetric dimethylarginine (ADMA) in heart failure (HF) are not known. The objectives of this study were to determine the possible association between M30 and ADMA and the potential use of M30 as an apoptotic marker in patients with HF. Material and Method: In this study M30 and ADMA concentrations were evaluated in 30 patients with heart failure and 30 healthy control subjects. Results: Increased M30 (p-0.01) and ADMA (p - 0.012) concentrations were found in the patients and a positive correlation was determined between ADMA and M30 in the patient group (p < 0.001, r- 0.627). No correlation was determined between M30, N terminal pro brain natriuretic peptide (NT-pro-BNP). and ejection fraction. Discussion: These results demonstrate that M30 can be used as a novel apoptotic serum marker in patients with heart failure. The apoptotic cascade activated by increased ADMA concentrations can be considered to contribute to the molecular mechanism of HF.
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    Effects of agmatine, glutamate, arginine, and nitric oxide on executive functions in children with attention deficit hyperactivity disorder
    (Springer Wien, 2020) Sari, Seda Aybuke; Ulger, Dilara; Ersan, Serpil; Bakir, Deniz; Uzun Cicek, Ayla; Ismailoglu, Firat
    In this study, we aimed to investigate the effects of agmatine, nitric oxide (NO), arginine, and glutamate, which are the metabolites in the polyamine pathway, on the performance of executive functions (EF) in attention deficit hyperactivity disorder (ADHD). The ADHD group included 35 treatment-naive children (6-14 years old) who were ewly diagnosed with ADHD. The control group consisted of 35 healthy children with the same age and sex, having no previous psychiatric disorders. In the study groups, Stroop test (ST) and trail making test (TMT) were used to monitor EF, and blood samples were collected to measure agmatine with ultra-high-performance liquid chromatography and NO, glutamate, and arginine with enzyme-linked immunosorbent assay (ELISA). The EFs were significantly impaired in the ADHD group. The agmatine and arginine levels of the ADHD group were significantly higher than their peers. The NO and glutamate levels were also higher in the ADHD group compared to the control group, but these differences did not reach statistical significance. Children with ADHD had more difficulties during EF tasks compared to healthy children. The elevated NO and glutamate levels may be related with the impairment during EF tasks. Therefore, agmatine and arginine may increase to improve EF tasks through its inhibitory effect on the synthesis of NO and glutamate. Further studies are needed about polyamine pathway molecules to shed light on the pathophysiology of ADHD.
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    Evidence supporting the role of telomerase, MMP-9, and SIRT1 in attention-deficit/hyperactivity disorder (ADHD)
    (Springer Wien, 2020) Uzun Cicek, Ayla; Mercan Isik, Cansu; Bakir, Sevtap; Ulger, Dilara; Sari, Seda Aybuke; Bakir, Deniz; Cam, Selim
    Growing evidence suggests that telomeres, telomerase, matrix metalloproteinase-9 (MMP-9), andSIRT1(sirtuin1) are involved in the pathophysiology of neuropsychiatric and neurodevelopmental disorders. However, whether these molecules are contributors to attention-deficit/hyperactivity disorder (ADHD) has been little explored and poorly understood. This study aimed to determine the potential role of telomerase, MMP-9, andSIRT1in children with ADHD. The study was performed on 46 children with ADHD aged between 8 and 14 and 43 healthy children matching in age and gender. Children were evaluated by Kiddie-Sads-Present and Lifetime Version, Conners' Parent Rating Scale-Revised Short Form (CPRS-RS) and Stroop test. Serum telomerase, MMP-9, andSIRT1levels were measured by a quantitative sandwich enzyme-linked immunosorbent assay. MMP-9 and telomerase levels were significantly higher andSIRT1levels were significantly lower in patients with ADHD than those of controls. All three molecules were significantly associated with both the severity of ADHD symptoms and cognitive functions. This is the first attempt to indicate that the important role of telomerase, MMP-9, andSIRT1in ADHD, and the association of all these molecules with the severity of ADHD and cognitive functions, but future studies are required to verify these results.
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    The significance of the neutrophil-to-lymphocyte ratio in differantial diagnosis of ectopic pregnancy and miscarriage
    (E-CENTURY PUBLISHING CORP, 2016) Karakus, Savas; Yildiz, Caglar; Akkar, Ozlem; Sancakdar, Enver; Ulger, Dilara; Cetin, Ali
    Objective: The aim of this study is to assess the diagnostic value of the neutrophil-to-lymphocyte ratio in the differential diagnosis of patients with vaginal bleeding related to ectopic pregnancy or miscarriage. Study design. A retrospective analysis of case histories of patients with documented ectopic pregnancies or miscarriages diagnosed by a combination of clinical examination, transvaginal ultrasonography, and human chorionic gonadotropin assay. Normal pregnant women were used as controls. The neutrophil-to-lymphocyte ratio was calculated in the patients and controls. Results: The neutrophil-to-lymphocyte ratio was higher in patients with ectopic pregnancies than in patients with normal pregnancies or patients with miscarriages (P<0.05). Although the neutrophil-to-lymphocyte ratio in patients with miscarriages was higher than that in patients with normal pregnancies, the difference was not statistically significant. For ectopic pregnancy, using 3.0 as a cutoff value, the sensitivity and specificity of the neutrophil-to-lymphocyte ratio were 61%. For miscarriage, using 2.8 as a cutoff value, the sensitivity and specificity of neutrophil-to-lymphocyte ratio were 53%. Conclusions: In patients with vaginal bleeding related to ectopic pregnancy or miscarriage, an increased neutrophil-to-lymphocyte ratio in the absence of infection may be used as an early diagnostic marker for ectopic pregnancy. Miscarriage did not result in a significant increase in the neutrophil-to-lymphocyte ratio. Further studies performed in patients grouped by gestational age and rupture status are needed to determine the diagnostic value of the neutrophil-to-lymphocyte ratio in patients suspected of an ectopic pregnancy.