Yazar "Unsal, Gulsah" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim Yok
    Öğe
    Mortality in patients with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
    (Cukurova Univ, Fac Medicine, 2025) Tunc, Gaffari; Korgali, Elif Unver; Mutlu, Muhammet Ali; Unsal, Gulsah; Gulturk, Esra Akaydin
    Purpose: Hypoxic-ischemic encephalopathy is a heterogeneous clinical syndrome that occurs in the perinatal period and is characterized by altered consciousness or seizures, respiratory depression, and hypotension. The aim of this study was to evaluate mortality in hypoxic-ischemic encephalopathy patients receiving therapeutic hypothermia. Materials and Methods: The study included 97 hypoxicUnit. The cases were evaluated for mortality and were divided into two groups: group 1 (n: 9, non-survivors) and complications of hypoxic-ischemic encephalopathy, APGAR scores, blood support, and laboratory parameters were evaluated for mortality. the risk of death. Conclusion: Mortality rates were significantly higher cases that developed Meconium aspiration syndrome associated hypoxic-ischemic encephalopathy than hypoxic-ischemic encephalopathy cases without meconium aspiration syndrome. A low APGAR score, increased number of intubation days, acute kidney injury, thrombocytopenia, and need for fresh frozen plasma were associated with a high risk of mortality in infants receiving therapeutic hypothermia for hypoxic-ischemic encephalopathy, and the presence of meconium aspiration syndrome significantly increased this risk.
  • Küçük Resim Yok
    Öğe
    Predictive markers of metabolically healthy obesity in children and adolescents: can AST/ALT ratio serve as a simple and reliable diagnostic indicator?
    (Springer, 2024) Celik, Nurullah; Unsal, Gulsah; Tastanoglu, Huseyin
    This study aimed to estimate the prevalence of metabolically healthy obesity (MHO) according to two different consensus-based criteria and to investigate simple, measurable predictive markers for the diagnosis of MHO. Five hundred and ninety-three obese children and adolescents aged 6-18 years were included in the study. The frequency of MHO was calculated. ROC analysis was used to estimate the predictive value of AST/ALT ratio, waist/hip ratio, MPV, TSH, and Ft4 cut-off value for the diagnosis of MHO. The prevalence of MHO was 21.9% and 10.2% according to 2018 and 2023 consensus-based MHO criteria, respectively. AST/ALT ratio cut-off value for the diagnosis of MHO was calculated as >= 1 with 77% sensitivity and 52% specificity using Damanhoury et al.'s criteria (AUC = 0.61, p = 0.02), and 90% sensitivity and 51% specificity using Abiri et al.'s criteria (AUC = 0.70, p = 0.01). Additionally, using binomial regression analysis, only the AST/ALT ratio is independently and significantly associated with the diagnosis of MHO (p = 0.03 for 2018 criteria and p = 0.04 for 2023 criteria).Conclusion: The ALT/AST ratio may be a useful indicator of MHO in children and adolescents.What is Known:center dot Metabolically healthy obesity refers to people who are obese but do not have any of the standard cardio-metabolic risk factors.center dot Metabolically healthy obesity is not entirely harmless; the metabolic characteristics of individuals with this phenotype are less favorable than those of healthy lean groups. Moreover, it is not a constant state, and there may be a transition to metabolically unhealthy phenotypes over time.What is New:center dot The prevalence of MHO is 21.9% and 10.2% according to 2018 and 2023 consensus-based metabolically healthy obesity criteria, respectively.center dot The ALT/AST ratio may be a useful indicator of metabolically healthy obesity in children and adolescents.