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Öğe Analysis of the Thickness of the Outer Retinal Layer Using Optical Coherence Tomography - A Predictor of Visual Acuity in Schizophrenia(Georg Thieme Verlag Kg, 2022) Bozali, Erman; Yalinbas, DuyguBackground The aim of this study was to evaluate the thickness of the outer retinal layer (ORL) together with macular thickness and changes in the retinal nerve fiber layer (RNFL) in patients with schizophrenia in comparison with healthy controls. Methods This study included 114 eyes of 57 patients diagnosed with schizophrenia and 114 eyes of 57 healthy controls. Central foveal thickness (CFT), central macular thickness (CMT), and ORL thickness were measured in both groups via the images obtained by spectral-domain optical coherence tomography (SD-OCT). RNFL was also assessed in four quadrants (inferior, superior, temporal, nasal). CMT measurements were presented as the average thickness of the macula in the central 1 mm area on the Early Treatment Diabetic Retinopathy Study (ETDRS) grid. The ORL thickness was defined as the distance between the external limiting membrane and retinal pigment epithelium at the center of the foveal pit. Results The mean age of 57 patients was 37 +/- 10 years, of whom 34 (60%) were male and 23 (40%) female. No statistically significant difference was found between groups in terms of age and gender (p = 0.8 for age, p = 0.9 for gender). There was no statistically significant difference in the mean CMT between the two groups (p = 0.1). The mean ORL thickness in the two groups was 99.8 +/- 8.3 and 103.7 +/- 6.2, respectively, and was significantly decreased in the schizophrenia group (p = 0.005). RNFL analysis demonstrated significant thinning in the inferior and superior quadrants compared to healthy controls (p < 0.001 and p = 0.017, respectively). Conclusions SD-OCT findings - especially ORL and RNFL thickness - may be related to the neurodegenerational changes in schizophrenia.Öğe Clinical Usefulness of a Computerized Vision Chart for Distance Stereoacuity Assessment in Children with Intermittent Exotropia(Taylor & Francis Inc, 2021) Ayyildiz, Onder; Yalinbas, Duygu; Ceylan, Osman Melih; Mutlu, Fatih MehmetIntroduction The aim of this study is to evaluate distance stereoacuity in children with intermittent exotropia (IXT) using a computerized vision chart (CVC), to compare the results to the normal subjects, and to determine if any correlation between stereoacuity and IXT severity exits. Methods A prospective case-control study was conducted including 24 children with IXT and 25 age-matched normal subjects. The mean age was 8.9 +/- 4.5 in IXT group and 9.4 +/- 4.2 in control group. The majority of patients (n = 17) had basic type IXT. Full ophthalmic examinations, deviations and stereoacuity tests were evaluated. Stereoacuity was measured with the CVC for distance stereoacuity and Randot stereotest book for near stereoacuity. Level of fusional control in patients with IXT was assessed using Newcastle Control Score (NCS). Seven of the patients with IXT were also reevaluated postoperatively. Results Near stereoacuity was good in both IXT and control groups, and there was no significant difference between groups. There was a poor correlation between near stereoacuity and NCS (r(s) = 0.15, p = .48). Distance stereoacuity in the IXT group was significantly reduced compared to controls (p = .004). There was a positive correlation between distance stereoacuity values and NCS in patients with IXT (r(s) = 0.73, p < .001). Conclusion Diminished distance stereoacuity in children with IXT can be detected with the CVC and this test may be useful for deciding the timing of surgical intervention and postoperative evaluation.Öğe Comparison of Ab Externo and Ab Interno 360-degree Suture Trabeculotomy in Adult Open-angle Glaucoma(Lippincott Williams & Wilkins, 2020) Yalinbas, Duygu; Dilekmen, Nilay; Hepsen, Ibrahim FeyziPrecis: Ab interno (gonioscopy-assisted transluminal trabeculotomy) and ab externo 360-degree suture trabeculotomy (ST) achieved similar success rates for reducing intraocular pressure (IOP) without serious complications threatening visual acuity. Purpose: We aimed to compare the efficacy of ab externo and ab interno 360-degree ST in reducing IOP, decreasing the number of antiglaucoma medications required, and decreasing the rates of intraoperative/postoperative complications in adults with open-angle glaucoma (OAG). Patients and Methods: This retrospective study included 33 eyes of 33 patients who underwent ab externo 360-degree ST (group 1) and 23 eyes of 23 patients who underwent ab interno 360-degree ST for OAG (group 2). We analyzed demographics as well as preoperative and postoperative (1, 3, 6, and 12 mo) data related to IOP, the number of antiglaucoma medications, complications, and surgical success rates. Results: In group 1, the mean IOP was 26.2 +/- 10.4 mm Hg, and the mean number of antiglaucoma medications was 3.2 +/- 1.0 preoperatively, decreasing to 11.2 +/- 3.0 mm Hg and 0.1 +/- 0.4 at 12 months, respectively (P<0.001, <0.001). In group 2, the mean IOP was 28.3 +/- 10.4 mm Hg, and the mean number of antiglaucoma medications was 3.5 +/- 0.9 preoperatively, decreasing to 13.3 +/- 6.5 mm Hg and 0.8 +/- 1.0 at 12 months, respectively (P<0.001, <0.001). Decreases in IOP at 6 and 12 months were similar in groups 1 and 2 (50% vs. 47%, P=0.6; and 51% vs. 49%, P=0.7, respectively). At 12 months, complete and qualified success rates were 88% and 97% for group 1 and 57% and 87% for group 2, respectively. The most common complications in both groups were hyphema and transient IOP spikes. Conclusion: Ab interno 360-degree ST is similar to ab externo 360-degree ST in terms of safety and efficacy in patients with OAG.Öğe Immediate Sequential Bilateral Vitrectomy Surgery for Retinopathy of Prematurity: A Single Surgeon Experience(Turkish Ophthalmological Soc, 2021) Ozdek, Sengul; Ozmen, Mehmet Cuneyt; Yalinbas, Duygu; Atalay, Hatice Tuba; Coskun, DemetObjectives: We report the safety and efficacy of simultaneous bilateral vitrectomy for stage 4 and stage 5 retinopathy of prematurity (ROP). Materials and Methods: Babies who had immediate sequential bilateral vitrectomy surgery for stage 4 or stage 5 ROP were included in this retrospective study. Clinical history, demographic characteristics of the patients, surgical procedure details, perioperative and postoperative ophthalmic and systemic complications, and postoperative anatomical success rates were evaluated. General anesthesia features were also recorded. Results: Seventy eyes of 35 babies who had immediate sequential bilateral vitrectomy surgery for stage 4 or stage 5 ROP were reviewed. At the time of surgery, the mean age was 41.4 +/- 4.9 weeks. There was preoperative plus disease in 58.6% of the eyes. The mean surgery/eye ratio was 1.2. Mean anesthesia time was 95 +/- 64 minutes. The mean follow-up was 28.1 months (3 to 84 months). Anatomical success was 95.7% for stage 4A (44/46 eyes), 83.3% for stage 4B (15/18 eyes), and 50% for stage 5 (3/6 eyes) ROP. Patients with stage 5 ROP had significantly less anatomical success than stage 4A and 4B (p=0.004). None of the patients had endophthalmitis and anesthesia-related severe complications. Conclusion: Immediate sequential bilateral vitrectomy surgery can be considered an option for patients with active bilateral stage 4 and stage 5 ROP. The risk of endophthalmitis should be weighed against the risks of disease progression and anesthesia-related complications.Öğe Increased Retinal Vessel Tortuosity Associated With Crimean-Congo Hemorrhagic Fever in Children(Lippincott Williams & Wilkins, 2021) Yalinbas, Duygu; Komurluoglu, Ayca; Bozali, ErmanBackground: To evaluate the ocular symptoms and findings of children diagnosed with Crimean-Congo hemorrhagic fever (CCHF). Methods: In this prospective study, children diagnosed with CCHF who underwent a complete ophthalmologic examination during the hospitalization period were included. Results: Twenty-four children with a mean age of 12.4 +/- 3.6 years were included study. The most common ocular finding was conjunctival hyperemia and was observed in 50% of patients. Nine (37.4%) children had abnormalities in fundus examination. Two (8.3%) of them had dilated retinal veins, and 7 (29.1%) had tortuous retinal vessels. No significant difference was found between mild to moderate and severe disease groups in terms of ocular symptoms and ophthalmologic examination findings (P > 0.05, for all). Conclusions: The increased retinal vessel tortuosity was detected as a fundus examination finding in children with CCHF. Both ophthalmologists and pediatricians should be aware of the various ocular manifestations of CCHF for rapid diagnosis and management.Öğe Purtscher-like Retinopathy Associated with Crimean-Congo Hemorrhagic Fever: A Case Report(Taylor & Francis Inc, 2022) Yalinbas, Duygu; Bozali, Erman; Vural, Ayse; Kocak, Husne; Erdogan, HaydarPurpose: To describe retinal findings and spectral-domain optical coherence tomographic (SD-OCT) features of a patient with Crimean-Congo hemorrhagic fever (CCHF) presenting as Purtscher-like retinopathy. Case report: A 70-year-old woman presented with the emerging bilateral blurring of vision. She had been diagnosed with CCHF one week ago and hospitalized in another hospital for treatment of disease. Fundoscopy of the patient revealed cotton-wool spots, retinal whitening areas, and few retinal hemorrhages in a Purtscher-like configuration in both eyes. Spectral-domain optical coherence tomography revealed inner retinal hyperreflectivity corresponding to the cotton-wool spots in both eyes, and also showed subretinal fluid in the left eye. Without any treatment retinal lesions and inner retinal hyperreflectivity on SD-OCT regressed within one month. Conclusion: Crimean-Congo hemorrhagic fever is known to cause mild ocular disease, and may also cause Purtscher-like retinopathy. It is important to aware of the ocular findings of CCHF.
