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Öğe Autopsy evaluation of coal mining deaths in the city of Zonguldak, Turkey(INT SCIENTIFIC LITERATURE, INC, 2014) Ozer, Erdal; Yilmaz, Riza; Evcuman, Durmus; Yildirim, Ali; Cetin, Ilhan; Kocak, Ugur; Ergen, KivancBackground: In this study, our aim was to evaluate the fatal occupational accidents that occurred in Zonguldak coal mines between the years 2005-2008. Material/Methods: We retrospectively evaluated 42 fatal coal mine occupational accidents in Zonguldak (Turkey) between the years 2005-2008. The forensic records of autopsies referred to the chief prosecutors' office during 2005-2008 were reviewed retrospectively. There were 42 cases. The cases were evaluated with respect to age, mechanism of injury, body region of wound, cause of death, and legality of the mine. Results: Ages of the deceased ranged between 17 and 52 (median: 32.9 yrs). Deaths were mostly in the 21-30 (35.8%), and 31-40 (30.9%) age groups. Only 1 case was younger than 18 years of age. Review of occupational fatalities has revealed that fatal accidents occurred mostly (76.2%) in the private, and fewer (23.8%) in the public mining enterprises. Crime scene investigation findings have demonstrated that of all occupational deaths (total n=42), 27 (64.3%) were due to subsidence, followed by methane gas poisoning (n=6, 14.2%), tram crash (n=3, 7.1%), log falls (n=2, 4.8%), electrocution (n=2, 4.8%), and methane explosion (n=2, 4.8%). Conclusions: Despite laws and regulations concerning mining and because of problems in their implementation, Turkey leads the world in work-related accidents, occupational injuries, and deaths. Evaluation of autopsy findings of deaths in fatal occupational accidents occurring in coal mines is quite important in planning to decrease rates of occupational fatalities.Öğe Deaths as a result of hanging(SCIENTIFIC PUBLISHERS INDIA, 2017) Ozer, Erdal; Yildirim, Ali; Kirci, Guven Seckin; Ilhan, Ramazan; Iscanli, Murat Dogan; Tetikcok, RamazanBackground: Death by hanging occurs as a result of the tightening of a cord around the neck with the effect of body weight. Although generally seen, it is not always necessary for hanging to be in a completely perpendicular position with the feet off the ground. With the exception of judicial cases, most hangings are suicides and in some cases may be the result of accident or murder. Material and method: In this study an evaluation was made of the autopsies of 48 cases of death by hanging in the province of Tokat, Turkey between 2009 and 2013. Through a retrospective evaluation of autopsy data, the cases were examined in respect of age, gender, location, type of hanging, instrument of hanging, fractures of the hyoid bone and thyroid cartilage and level of alcohol and other substances in the blood. In the evaluation of the data, the SPSS 11.0 software was used. Results: The cases were 35 (73%) males and 13 (27%) females with a mean age of 34.56 years; males, mean 35.37 years and females, mean 32.38 years. Typical hanging was determined in 42 (87.5%) cases. Fracture of the hyoid bone was seen in 14 (29.2%) cases and fracture of the thyroid cartilage in 13 (27%) cases. With the exception of 2 cases, ecchymosis was found in the fracture region of all the other cases. Ethanol was determined in the blood of 8 (16.6%) cases and other substances in the blood of 2 (6.2%) cases. Conclusions: In every case of hanging, the autopsy and toxicology and histopathology examinations made following autopsy are extremely important in respect of differential diagnosis and determining whether or not it is a case of suicide or whether the hanging occurred after death.Öğe The effect of colchicine on alveolar bone loss in ligature-induced periodontitis(SOCIEDADE BRASILEIRA DE PESQUISA ODONTOLOGICA, 2019) Toker, Hulya; Yuce, Hatice Balci; Yildirim, Ali; Tekin, Mehmet Bugrul; Gevrek, FikretColchicine is widely used in the treatment of several inflammatory diseases due to its anti-inflammatory effect, but effects on bone metabolism are unclear. The aim of this study was to evaluate the effects of systemically-administered colchicine on healthy periodontium and experimentally-induced periodontitis. In total, 42 male Wistar rats were included in this study. A non-ligated group constituting the negative control group (Control, C, n = 6) and a ligature-only group forming the positive control group (LO, n = 12) were created separately. Twelve rats were treated with 0.4 mg/kg colchicine and another 12 with 1 mg/kg colchicine. In the colchicine-administered groups, right mandibles constituted the ligated groups (1 mgC-L or 0.4 mgC-L) and left mandibles formed the corresponding non-ligated controls (1mgC or 0.4mgC). Silk ligatures were placed at the gingival margin of the lower first molars. The animals were euthanized at different time-points of healing (11 or 30 days). Alveolar bone loss was clinically measured and TRAP+ osteoclasts, osteoblastic activity, and MMP-1 expression were examined histologically. There was no increase in alveolar bone loss with either colchicine dose in healthy periodontium (p > 0.05) and the highest level of alveolar bone loss, TRAP+ osteoclast number, and MMP-1 expression were measured in the LO group (p < 0.05). The 0.4 mgC-L group showed less alveolar bone loss at 11 days (p < 0.05), but greater loss at 30 days. The 1 mgC-L group showed higher osteoblast number than the other ligated groups (p < 0.05) at both time-points. In summary, colchicine did not increase alveolar bone loss in healthy periodontium and also may tend to reduce periodontitis progression. However, further extensive study is necessary to understand the mechanism of colchicine action on alveolar bone loss in periodontitis.Öğe Effects of Lactobacillus Rhamnosus on dental implant osseointegration in osteoporotic rabbit model(Bayrakol Medical Publisher, 2021) Saygin, Aysegul Goze; Gorler, Oguzhan; Yildirim, Ali; Ercan, Nazli; Goze, Omer FahrettinAim: The effect of Lactobacillus rhamnosus (LR), probiotic bacteria that manage inflammatory disease, on osseointegration is unknown. The study aimed to evaluate the effects of LR administration on osseointegration in experimental osteoporosis induced by ovariectomy. Material and Methods: Sixteen New Zeland female rabbits were randomly divided into the following groups: SHAM (SH), SHAM and LR (SH+LR), Ovariectomy (OVX), OVX and LR (OVX+LR). Animals in the OVX group were subjected to bilateral ovariectomy to create artificial osteoporosis. After 16 weeks, a titanium dental implant was bilaterally implanted into each tibia of the animals. Animals in the SH+LR and OVX+LR groups were given oral probiotics. All animals were sacrificed and all tibia bones were separated at postoperative 8 weeks after implantation. Cardiac blood was taken to determine biochemical markers. Resonance frequency analysis (RFA) and bone-to-implant contact area (BIC) were administered. Results: RFA and BIC area were statistically significant for osseointegration in OVX+LR compared with OVX (p<0.05). The BIC area in the OVX group was statistically lower (p<0.05). ALP, BALP, Trap5b and MPO were highest in OVX groups(p<0.05). Discussion: This study concluded that osseointegration may be improved by LR administration in an estrogen-deficient state. The success rate of the implant may be increased by using probiotics in patients with osteoporosis.Öğe Evaluation of death cases in the 0-1 age group in Sivas, Turkey(ALLIED ACAD, 2017) Butun, Celal; Beyaztas, Fatma Yucel; Yildirim, Ali; Ozer, Erdal; Can, Muhammet; Uzun, Ayla; Yilmaz, Riza; Dokgoz, HalisIntroduction: In cases of infant deaths that have the legal nature, there are problems in determining the causes of death. Post-mortem assessments in this age group require the more different approaches than adults for both autopsy techniques and examinations. Aim: By examining the infant death cases, it was aimed to draw attention to the points to be considered in the autopsy cases and the causes of death which can be reduced. Method: The forensic autopsies of 44 cases at the age of 0-1 y been undergone between 2008-2015 y in Cumhuriyet University Medical Faculty Hospital morgue were included in our study. Age, gender, medical records, crime scene characteristics, autopsy and laboratory findings of these cases were discussed in the light of the literature. Result: Sixteen of the 44 cases were male and 26 were female. Sex discrimination of two cases could not be done due to severe putrefaction. When evaluated according to age groups, the largest group (27.3%) was composed of cases between 2-6 months of age. When the causes of death determined in the reports were examined, natural causes of deaths detected at the majority of cases (45.5%). Conclusion: Consequently, assessment of infant deaths requires an elaborate autopsy, careful crime scene investigation and detailed medical information of the infant and his/her family.Öğe The evaluation of deaths due to methyl alcohol intoxication.(ALLIED ACAD, 2017) Kurtas, Omer; Imre, Kemal Yavuz; Ozer, Erdal; Can, Muhammet; Birincioglu, Ismail; Butun, Celal; Kirci, Guven Seckin; Yildirim, Ali; Kiyak, Samet; Yilmaz, RizaBackground: Methanol poisoning is a serious medical, social and economic problem that may cause severe illness or death. After methanol ingestion, central nervous system depression, headache, dizziness, nausea, lack of coordination, and confusion begins. Once the initial symptoms have passed, a second set of symptoms arises, 10 to 30 hours after the initial exposure to methanol, including blurring or complete loss of vision and acidosis. Methanol poisoning by ingestion is a world-wide problem, and in some regions it is connected with high morbidity and mortality. The lethal dose of methanol in humans shows pronounced individual differences ranging from 15 to 500 ml. Methods: The records of the First Specialization Board of the Council of Forensic Medicine between 2002 and 2010 were reviewed retrospectively for all methyl alcohol poisoning cases. Results: There were 383 cases recorded. 360 (94%) of total fatalities were men and 23 (6%) were women. The age range was between 17 and 89. Although patients were conscious, cooperative, oriented at first, deteriorated general health state, metabolic acidosis and neurologic sequelae with severe electrocardiographic (ECG) changes were seen in progress of time. The laboratory findings and MRI imaging method were applied to assess progress and medical treatment. Unfortunately severe acidosis, central nervous system (CNS) sequelae and a lethal outcome occurred. The methyl alcohol blood concentrations ranged from 0 to 826 mg per 100 ml. The most common macroscopic and microscopic finding was lung edema, cerebral and cerebellar hemorrhage, ischemic changes in the brain and optic neuritis. Putaminal necrosis and hemorrhage, brainstem petechial hemorrhage, myocardial acute ischemic changes, thalamic and hypothalamic hemorrhage were detected rarely. Conclusions: This is the first study to report postmortem findings, clinical reports, crime scene reports and eye witness accounts to investigate methyl alcohol poisoning cases from medico-legal point of view in Turkey. Methanol poisoning by ingestion is a world-wide problem with high morbidity and mortality. For preventing methanol deaths, both awareness and public education must be increased.Öğe Evaluation of forensic deaths occurred in Sivas, Turkey(DRUNPP-SARAJEVO, 2012) Butun, Celal; Beyaztas, Fatma Yucel; Yildirim, Ali; Saka, N. Esra; Ozen, BahadirBackgrounds: Despite rapid developments in the science of medicine, increased number of innovative laboratory and imaging technologies; autopsies have a crucial role in gathering and transferring valuable information. Methods: In this study; medical records and autopsy reports of forensic cases resulting in death between 2006 and 2009 in Sivas were examined, and evaluated as for medical and socio-demographic aspects. Results: Total of 540 cases assessed consisted of 393 (72.8%) males mostly (n=159; 29.4%) over 60 years of age. Deaths were mostly seen during summer (n=154; 28.5%), and suspected deaths lead the way (n=144; 26.7%), followed by traffic accidents (n=138; 25.6%). Death certificates were arranged for 425 (78.7%) cases following postmortem examinations. Conclusions: Findings in this study have shown some similarities with those of the literature. Since highest mortality rates are seen secondary to accidents, relatively simple preventive measures have vital importance. Traffic accidents, and falls from height which are among preventable causes of mortality still remain to be a challenging problem in our country and implementation of necessary safety measures, and training on this subject are of paramount importance.Öğe Frontal lobe syndrome developing after head trauma: case report(CUMHURIYET UNIV TIP FAK PSIKIYATRI ANABILIM DALI, 2015) Cevik, Betul; Yildirim, Ali; Aksoy, Durdane; Ozer, Erdal; Kurt, SemihaFrontal lobe syndrome (FLS) is a clinical picture caused by damages due to reasons like prefrontal cortex cerebrovascular disease, tumor, infection or head trauma and displaying itself through distinct and permanent personality, social adaptation, and behavior changes. A 13-year-old, right-handed male case was in deep coma for 1.5 months after a traffic accident 28 months ago. His brain tomography revealed fractures in right orbital floor and anterior skull base, subarachnoid hemorrhage, right frontal contusion, left frontal epidural hematoma and pneumo-cephalus. Two months after the accident, case could perform simple commands and was right hemiplegic and motor aphasic. Motor deficit was treated through rehabilitation. His family was complaining about his hoarseness, inattentiveness, forgetfulness, overeating, meaningless crying, itchiness, nervosity, aggressiveness, swearing, and repeating the same sentence. In the examination, he had partial time orientation, intermediate self-care, increased euphoric, psychomotor activity, labile and inappropriate affect, disinhibition, no insight, hoarse voice, foul language, near-far memory disorder and impaired reading, writing, calculating and judging compared to his peers. FLS was considered for the patient. This case was reported since his daily-life activities considerably deteriorated due to FLS remaining as sequellae despite full recovery in deep coma and motor deficit, developing after head trauma.Öğe A Nonrandom Sample of 55 Sexual Abuse Cases in Sivas(INT SCIENTIFIC INFORMATION, INC, 2017) Butun, Celal; Yildirim, Ali; Ozer, Erdal; Yilmaz, Eda; Sari, Seda AybukeBackground: Sexual abuse in childhood is a significant public health problem because of the destructive results both to the individual and to the community. The aim of this study was to examine the sociodemographic characteristics of children who were victims of sexual abuse, the relationship of the victim and abuser, and the findings of sexual abuse. Material/Methods: An examination was made of the results of forensic medicine and psychiatric evaluations of child victims of sexual abuse. The sociodemographic characteristics of the cases and the characteristics of the incidents of sexual abuse were evaluated at the Forensic Medicine Department of Cumhuriyet University between 2013 and 2016. Results: A total of 55 cases were included in the study, comprising eight males (14.5%) and 47 females (85.5%) in the age range of 5-17 years. The vast majority of the cases were high school students. The place of the abuse incident was the home of the victim or the perpetrator in 29 cases (52.7%). The sexual abuse was determined to be bodily penetration in 32 cases (58.1%). In 32 cases (58.1%), the perpetrator was known to the victim. Conclusions: The study findings that the perpetrator of the sexual abuse was known to the child, that predominantly female children were attacked, and the low sociocultural level of the cases were consistent with other studies reported in the literature. To prevent sexual abuse of children, to make an early diagnosis, and to provide rehabilitation for the abused children, it is essential that the evaluations of these cases are made using a professional multidisciplinary approach.Öğe Sexual abuse and assault victims; comparing the characteristics of adolescent and adult victims(SCIENTIFIC PUBLISHERS INDIA, 2016) Ozer, Erdal; Taycan, Serap Erdogan; Yildirim, Ali; Celikel, Feryal Cam; Tetikcok, Ramazan; Gumus, BurakObjectives: In this study, it is aimed to evaluate the data of the cases subjected to the sexual abuse/assault and to compare various characteristics according to the age. Method: Information of the sexual abuse cases examined by the Psychiatry Department between September 2010-2011 was obtained retrospectively. Descriptive analysis was done and independent group's rates were compared with chi-square test. Results: Fifty (62.5%) of the cases were under 18 and 30 (37.5%) of them were over 18 years old. The youngest case was 15 years old. In the group aged below 18 years the female: male ratio was 96%: 4% and in the group aged over 18 years, it was 89.3%: 10.7%. Under 18 years, 4 (8%) cases were married by religious ceremony only, 1 (2%) case had separated from the spouse of a religious marriage and 45 (90%) cases were single. Over 18 years, 9 cases (30%) were married, 15 (50%) were single and 4 (13.3%) were divorced. In both groups, the proportions of women were significantly higher than men. In both groups it was determined that the majority of the abusers were familiar persons. There was not any difference between the groups by means of the familiarity of the abuser, place where the incident occurred, type of the abuse and the diagnosis determined by the psychiatric examination after sexual abuse. Conclusion: It is important to determine that the women composed of the majority of the cases in both groups, abusers were generally familiar persons, boyfriend abuses were more prevalent in the adolescent group and there were several cases that had religious marriages in the adolescent group. More studies are needed in this field in order to maintain a standard evaluation of the sexual abuse cases and minimize the understanding and language differences between law enforcement and health care providers.Öğe The effect of luteolin in prevention of periodontal disease in Wistar rats(Wiley, 2019) Yuce, Hatice Balci; Toker, Hulya; Yildirim, Ali; Tekin, Mehmet Bugrul; Gevrek, Fikret; Altunbas, NiluferBackgroundPeriodontal disease is the chronic infectious disease of the periodontium. Because of irreversibility, prevention of disease is one of the most important goals of periodontal treatment. The aim of this study was to evaluate the effect of luteolin, a powerful anti-inflammatory agent, on the prevention of experimental periodontitis by determining morphological and histological tissue alterations. MethodsThis study consisted of 28 rats and four experimental groups: healthy control group (C, n = 6); periodontitis group (P, n = 6); periodontitis and 50 mg/kg luteolin administered group (L-50, n = 8); and periodontitis and 100 mg/kg luteolin administered group (L-100, n = 8). Experimental periodontitis was induced via ligature method around lower right first molar teeth. All rats were euthanized 11 days after. The severity of periodontal destruction was determined by measuring alveolar bone loss under a stereomicroscope. Osteoblast and inflammatory cell counts were counted on hematoxylin-eosin-stained slides and osteoclasts were counted on tartrate-resistant acid phosphatase-stained slides. The levels of inducible nitric oxide synthase (iNOS), bone morphogenetic protein (BMP)-2, matrix metalloproteinase (MMP)-8, tissue inhibitor of MMP (TIMP)-1, receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were determined by immunohistochemistry. ResultsThe highest alveolar bone loss was observed in the periodontitis group and the luteolin administration decreased bone loss in both groups. Osteoblast cell number was higher and osteoclast and inflammatory cell numbers were lower in the P group compared to C, L-50, and L-100 groups. Luteolin, dose-dependently increased osteoblast cell counts. Luteolin attenuated periodontal inflammation in both L-50 and L-100 groups. Like osteoblast cell numbers, BMP-2 expressions were also elevated in luteolin groups. Both doses of luteolin significantly increased TIMP-1 and BMP-2 expressions and decreased MMP-8 levels. iNOS expressions increased in P group and L-100 significantly decreased iNOS levels. RANKL increased and OPG decreased in P group and 100 mg/kg luteolin increased OPG and decreased RANKL levels significantly. ConclusionsWithin the limits of present experimental study, luteolin successfully improved periodontal health in a ligature-induced experimental periodontitis model in Wistar rats. The decrease in inflammation, osteoclastic and collagenase activity and increase in osteoblastic activity are possibly involved in this process.Öğe The short-term effects of various xenografts on bone healing in rats cranial defects(Scientific Publishers of India, 2018) Develioğlu, Hakan; Özcan, Gönen; Gültekin, Sibel Elif; Sengüven, Burcu; Yildirim, AliPurpose: Xenografts can be used in dentistry and medicine for both clinical and experimental purposes. The goal of the investigation was to observe the short-term bone building outcomes of two xenografts (Gen Os and Gel 40) in the cranial bone defects in rats. Methods: Twelve rats were divided into two groups randomly, and a total of 24 parietal bone defects were created on the parietal bones. The symmetrical defects were in the critical size 5 mm and circular, which were treated with Gen Os in group 1, with Gel 40 in group 2, and symmetrical defects left empty as the controls. Rats were sacrificed 40 d after surgery, and the block sections, including the defects, were removed. The bone formation was assessed both histologically and histomorphometrically. Results: There was more bone building in the test groups when compared to the controls (p<0.05). Besides, no difference was seen between the two test groups (p>0.05). A significant difference was also found among the three groups regarding the inflammation scores (p<0.05). Conclusion: Within the limitations of the study, it can be concluded that both materials were osteoconductive, and more bone building was proved in the Gel 40 group. © 2018, Scientific Publishers of India. 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