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    Analysis of patients with upper gastrointestinal bleeding: a study from Anatolian, Turkey Seasonal Distribution of Gastrointestinal Bleeding
    (DRUNPP-SARAJEVO, 2012) Korkmaz, Ilhan; Eren, Sevki Hakan; Guven, Fatma Mutlu Kukul; Beydilli, Inan; Yildirim, Birdal; Oguzturk, Hakan
    The aim of our study was to analyze if we have a seasonal or circadian distribution of acute upper gastrointestinal bleeding (AUGIB) patients, and to evaluate the laboratory and demographic risk factors on mortality rates. We scanned all of the files of the patients who had been diagnosed with AUGIB, for a ten year period. Datas' about seasonal distribution, circadian rhythm, admission hemoglobin, blood urea nitrogen and demographic variables were extracted from the charts. We didn't observed a seasonal distribution for AUGIB inspite of we excluded the drug effect by analyzing its seasonal distribution. Also our patients were admitted mostly nights which was compatible with the literature. Whereas our admission rate between 24 and 06 hour period was low. Admission low hemoglobin level, impaired blood urea nitrogen and creatinine level, and patients with advanced age has a higher mortality rate (p=0.03, p=0.003, p=0.02, p=0.001 respectively). Climatic factors effect on the seasonal distribution among AUGIB patients is not observed. Other risk factors (mental-physical) should also be evaluated. Low hemoglobin level, impaired renal functions and advanced age are bad risk factors for prognosis.
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    Association between anticardiolipin antibodies, serum protein C levels and acute myocardial infarction
    (DRUNPP-SARAJEVO, 2012) Yildirim, Birdal; Topal, Fatih Esad; Topal, Firdevs; Korkmaz, Ilhan
    Objective: Anticardiolipin antibodies and protein C deficiency and/or resistance are among the well-known hypercoagulability syndromes. We wanted to investigate whether serum levels and activity of Protein C and/or anticardiolipin antibodies were different in patients who admitted with acute ST elevation myocardial infarction from healthy controls. Patients and methods: Fifty patients who admitted to the emergency department within 6 hours of onset of chest pain and diagnosed as acute ST elevation myocardial infarction was included. Complete blood count, biochemistry, CK, CKMB and Troponin T levels were measured after a complete physical examination. Control group consisted of age and sex matched healthy individuals with no symptoms or signs of coronary artery disease or history of coronary artery disease. Protein C activity and anticardiolipin IgM, IgG and IgA were measured in the core laboratory of the hospital. Results: Protein C activity of the AMI group and the control group did not reveal significant difference although mean Protein C activity was higher compared to control group (148.16 +/- 7.51 vs 135.64 +/- 4.8; p>0.05). Anticardiolipin IgG levels were higher in AMI patients than the controls (10.09 +/- 0.62 vs 5.5 +/- 0.36 p<0.01) as well as anticardiolipin IgM levels (10.27 +/-.13 vs 7.8 +/- 0.37 p<0.01). Conclusion: It is important to detect high-risk groups in terms of recurrent thrombosis. Larger studies with standardized measurement of anticardiolipins may clarify whether hypercoagulability should be investigated in at least some high-risk acute myocardial infarction survivors.
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    Baseline characteristics and the association between hyponatraemia and pulmonary embolism prognosis
    (PAKISTAN MEDICAL ASSOC, 2013) Korkmaz, Ilhan; Guven, Fatma Mutlu Kukul; Eren, Sevki Hakan; Beydilli, Inan; Yildirim, Birdal; Aktas, Can; Alagozlu, Hakan
    Objective: To evaluate the effect of hyponatraemia on pulmonary thromboembolism mortality rates. Methods: The retrospective study was conducted at the Cumhuriyet University Medicine Faculty's Emergency Department, and involved the analysis of records related to all patients who were diagnosed with acute pulmonary thromboembolism between January 2005 and June 2011. Diagnoses were confirmed by pulmonary angiography, multi-slice computed tomography or high-probablity ventilation/perfusion scintigraphy. All patients (n=260) were over 16 years of age. SPSS 14 was used for statistical analysis. Results: Plasma sodium level, platelet count and hospitalisation time were significiantly lower among those who died (n=16; 6.29) (p<0.005, p<0.035, p<0.035). Pearson correlation analysis found a negative correlation between plasma sodium level and C-reactive protein, white blood cells and pulmonary artery pressure (r=-0.238, p<0.001; r=-0.222, p<0.001; r=-0.444, p<0.018 respectively). A positive correlation was found between plasma sodium level and hospitalisation time (r=0.130; p<0.039). Conclusion: While mortality rates in hyponatraemic pulmonary thromboembolism patients increases, low plasma sodium is an easy parameter that should be kept in mind for the prognosis of pulmonary thromboembolism disease.
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    Carbon Monoxide Intoxication Induced Atrial Fibrillation
    (Galenos Yayincilik, 2012) Korkmaz, Ilhan; Eren, Sevki Hakan; Guven, Fatma Mutlu Kukul; Turkdogan, Ahmet; Beydilli, Inan; Yildirim, Birdal
    Carbon monoxide (CO) is a colorless, odorless gas which is a leading cause of accidental deaths during winter months. Its toxic effect occurs by binding to hemoglobin or directly at cellular level. Electrocardiographic findings due to CO intoxication are STsegment changes, premature contractions, sinus tachycardia, bundle blocks and atrial fibrillation (AF). We report a 33-year-old man who presented with AF due to CO poisoning. The patient was treated with anti-ischemic drugs and oxygen therapy.