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    ANTI-INFLAMMATORY ACTIVITY OF TURKEY SOURCE PUMPKIN SEED OIL IN RAT EDEMA MODEL
    (Polskie Towarzystwo Farmaceutyczne, 2020) Arslanbas, Emre; Kara, Haki; Karayigit, Mehmet Onder; Dogan, Halef Okan; Yildiz, Seyma Nur
    This study aimed to determine the effects of Turkey-sourced pumpkin seed oil (PSO), administered orally to rats in different dosages, to research its anti-inflammatory effect in rat edema model, induced by carrageenan, based on different dosages, and to evaluate its effects comparatively with indomethacin. The study was conducted on 42 rats in total, divided into 7 groups (control, carr, PSO40, PSO100, PSO40+carr,PSO100+carr and indo+carr). In the study, doses of 40 and 100 mg/kg of PSO were found to significantly sup-press rat paw edema in time, and it was observed that this effect was more pronounced in the fourth hour. It was found that MDA and cytokine (TNF-alpha, IL-6, IL-1 beta) levels were inhibited, and GPX and SOD activities were enhanced in groups that received PSO and indo+carr groups. Histopathological examinations also support these findings. As a result of the study, the significant anti-inflammatory effect of Turkey-sourced PSO was attributed to the existence of unsaturated fatty acids and enriched phytochemical compounds.
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    Elevated Levels of Activin-A, TNF-Alpha and IL-6 in Acromegaly
    (Maik Nauka/Interperiodica/Springer, 2021) Dogan, Kubra; Yildiz, Seyma Nur; Sariakcali, Baris; Duman, Gulhan; Bolat, Serkan
    Although systemic inflammation has been linked to acromegaly, little is known about the abnormalities in cytokine networks during the disease. The aim of this study was to evaluate the serum concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and activin-A in acromegaly, and to investigate the relationship between TNF-alpha, IL-6, activin-A and comorbidities of acromegaly. A total of 56 subjects were recruited to the study. Serum samples were collected from 31 acromegaly patients and 25 healthy control subjects. Serum activin-A, IL-6 and TNF-alpha were determined using the enzyme-linked immunosorbent assay. Circulating levels of activin-A, TNF-alpha, and IL-6 were higher in patients than in the control group. Receiver operating characteristic analysis for activin-A for the differentiation of acromegaly patients from healthy control subjects showed an area under the curve of 0.90. Higher activin-A levels were determined in patients with residual pituitary tumor. These findings provide evidence for the role of activin-A, TNF-alpha and IL-6 in acromegaly. Serum activin-A levels could be used as a novel biomarker to diagnose acromegaly. These findings confirm previous studies that inflammation might be involved in the pathogenesis of acromegaly. Finally, treatment strategies targeting the regulation of inflammation cannot be sufficient alone in reducing comorbidities.
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    Metabolomic profiling in ankylosing spondylitis using time-of-flight mass spectrometry
    (Elsevier, 2022) Dogan, Halef Okan; Senol, Onur; Karadag, Ahmet; Yildiz, Seyma Nur
    Background & aims: Ankylosing spondylitis (AS) is an inflammatory disease associated with destructive changes in the skeleton and joints. The exact molecular mechanism of the disease has not been fully elucidated. This study aimed to determine metabolic differences between active AS patients and healthy controls to understand the molecular mechanism of AS. Patients and methods: The study included 38 subjects, comprising 18 patients with active AS and 20 healthy controls. Metabolic profiling of the plasma was performed using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC Q-TOF/MS). Data acquisition, classification, and identification were achieved with the METLIN (https://metlin.scripps.edu/) database and XCMS (https://xcmsonline.scripps.edu). Results: Significant alterations were identified in the unsaturated fatty acids (FA), linoleic acid, alphalinolenic acid, FA degradation, and FA biosynthesis pathways. Down -regulations were observed in phosphatidylcholine (PC) (16:0/0:0), beta-D-Fructose, stearic acid, trimipramine N-Oxide and muconic acid, and up-regulation were detected in PC (18:2/0:0), 3-Methylindole, palmitic acid (PA), alphaTocotrienol, and beta-D-glucopyranoside in active AS patients compared to the healthy control subjects. Conclusion: Pathway analysis revealed that dysregulation in FA metabolism is associated with AS, and therefore, modulation of diet according to PA and PC may be potential therapeutic targets. (C) 2022 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.
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    Urine iodine deficiency in pregnant women living in Sivas
    (DERMAN MEDICAL PUBL, 2018) Dogan, Halef Okan; Karakaya, Ozgur; Dogan, Kubra; Karakus, Savas; Yildiz, Seyma Nur
    Aim: The study aimed to assess the iodine status and maternal thyroid function in the pregnant women in Sivas that is a city in central Turkey. Material and Method: One hundred-ninety-three pregnant women in their second trimester who attended the hospital for routine antenatal care were included this study. Morning spot urine samples were collected in deiodized test tubes from the study population. Urine iodine levels were determined by colorimetric modified Sandell-Kolthoff reaction. Serum free triiodothyronine (fT3), free thyroxine (fT4) and thyrotropin (TSH) levels were measured by electrochemiluminescence immunoassays. Results: Median urine iodine levels were lower in Sarkisla, Susehri Gurun, Divrigi and Kangal than Sivas Center. Median urine iodine deficiency levels of pregnant women living in Sarkisla, Susehri Gurun, Divrigi and Kangal indicated mild iodine deficiency. Discussion: Iodine deficiency is a significant problem in Sivas. Therefore, there is need for a policy such as iodine prophylaxis for pregnant women living in Sivas to eliminate this problem.