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    Level of Serum Adiponectin in Sjogren's Syndrome
    (Erciyes Univ Sch Medicine, 2019) Dogan, Kubra; Urhan, Muhammad Emre; Yildiz, Seymanur; Derin, Emin; Sahin, Ali; Dogan, Halef Okan
    Objective: To evaluate the serum adiponectin level and determine the association between adiponectin and various clinical and laboratory findings in patients with primary Sjogren's syndrome (pSS). Materials and Methods: A total of 50 patients and 30 healthy volunteers were enrolled in the present study. Serum adiponectin levels were detected by colorimetric enzyme-linked immunosorbent assay. The medical history of patients including complete blood count analysis; high sensitive C-reactive protein; erythrocyte sedimentation rate (ESR); complement component 3; complement component 4; low density lipoprotein cholesterol; triglyceride; immunoglobulin G (IgG), IgA, and IgM levels; and the status of Ro 60, Ro 52, Sjogren's syndrome A, Sjogren's syndrome B, and rheumatoid factor were obtained from laboratory information system. Results: Serum adiponectin levels were 2.34 (0.77-4.95) ng/mL and 1.73 (0.01-7.76) ng/mL in patients and controls, respectively (p=0.316). Positive correlation was observed between the values of serum adiponectin, ESR (p=0.013, rho=0.362), and body mass index (p=0.018, rho=0.362) in patients. Conclusion: These findings indicate that adiponectin does not play a crucial role in the immunological and clinical patterns of pSS.
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    Serum TLR9 and NF-?B Biochemical Markers in Patients with Acute Pancreatitis on Admission
    (Hindawi Ltd, 2020) Demirtas, Erdal; Korkmaz, Ilhan; Cebecioglu, Kivanc; Ayan, Mustafa; Demirtas, Esin; Yurtbay, Sefa; Yildiz, Seymanur
    Aim. The aim of this study was to investigate the serum TLR9 and NF-kappa B levels in patients for the diagnosis and prognostication of AP in the emergency department. Methods. In the current study, we looked at the TLR9 and NF-kappa B pathways in a cohort of 45 acute pancreatitis patients and compared them with the control group. We also divided the patient groups as mild-moderate or severe and compared the biomarker levels between the groups. Results. Of the patients with acute pancreatitis, 22 (49%) were male and 23 (51%) were female. The mean age of the patient group was 62 years, with a range of 25-95 years. The control group consisted of 19 (43.1%) male and 25 (56.9%) female patients. The serum TLR9 and NF-kappa B values were significantly higher than those of the control group [1104.44 +/- 339.20 vs. 702.08 +/- 203.94; p<0.001 and 8.04 +/- 1.76 vs. 4.76 +/- 1.13; p<0.001, respectively]. We found that TLR9 and NF-kappa B had a significant discriminative ability, while the cutoff value for TLR9 was 950.4, with a sensitivity of 73% and specificity of 93% (p<0.001), and the cutoff value for NF-kappa B was 6.32, with a sensitivity of 89% and specificity of 100% (p<0.001). Conclusion. We demonstrated that the TLR9 and NF-kappa B pathway is activated in acute pancreatitis and increases the inflammatory process. This may help to further understand the pathogenesis of disorder, diagnosis, and clinical severity. We proposed that blockage of these inflammatory pathways may play a role in the prevention of the disease progression and development of inflammatory complications.