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    Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig
    (2021) Durna Daştan, Sevgi; Dey, dipta; Quispe, christina; hossain, rajib; jain, divya; Khan, rasel Ahmed; Janmeda, Pracheta; Islam, Muhammed toregul; Suleria, hafız ansar Rasul; Morterell, Miguell; Kumar, Manoj; tahari, yasaman; Petkovska, anka trajkovska; Rad, Javad sharifi
    .e mangrove plants are the potential sources of foods and remedies for people living in the forests and nearby communities. Xylocarpus granatum J. Koenig is traditionally used to treat various diseases including diarrhea, cholera, dysentery, fever, malaria, and viral infections, among others. To summarize critically the taxonomy, ethnomedicinal, phytochemistry, and pharmacological activities of X. granatum, information was collected from different databases. An up-to-date search (till June 2020) was carried out with the help of various scientific web resources from databases such as PubMed, Science Direct, Google Scholar, and various patent offices (e.g., WIPO, CIPO, and USPTO) using the keywords “Xylocarpus granatum” and then paired with ethnomedicinal use and phytochemical, phytochemistry, and pharmacological activity (in vitro, ex vivo, and in vivo studies). Findings revealed that seeds, fruits, stem bark, leaf, and twigs of X. granatum exhibited a wide range of key phytochemicals including limonoids, phragmalin, limonoid-based alkaloids, mexicanolides, protolimonoids, flavonols, and lactones. .e plant possessed potent antioxidant, anticancer, antidiabetic, antimicrobial, antimalarial, antifeedant, and neuroprotective activities. No clinical studies have been reported in the databases. Ethnomedicinal assessment indicated the application of X. granatum in various fields of medical science specially to treat various human ailments, and this was attributed to the presence of enormous alkaloids as confirmed by pharmacological studies. However, to understand the mechanism of action in-depth studies are required. In view of these findings, more research is necessary to explore and characterize the chemical compounds and toxicological aspects of this medicinal mangrove plant. Overall, it can be stated that X. granatum may be one of the hopeful medicinal herbs for the treatment of various diseases in human beings.
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    Lasia spinosa Chemical Composition and Therapeutic Potential: A Literature-Based Review
    (2021) Durna Daştan, Sevgi; hossain, rajib; Quispe, christina; Herrera-Bravo, jesus; Islam, shahazul; Sarkar, chandan; Islam, Muhammed toregul; Morterell, Miguell; Cruz-martins, natalia; al-harrasi, Ahmed; Al-rawahi, Ahmed; Rad, Javad sharifi; Ibrayeva, Manshuk; Al-shehri, Mohammed; Calina, daniela; Cho, William c
    Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in databases such as PubMed, Science Direct, and Google Scholar using the keywords: “Lasia spinosa,” then combined with “ethnopharmacological use,” “phytochemistry,” and “pharmacological activity.” This updated review included studies with in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological Hindawi Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 1602437, 12 pages https://doi.org/10.1155/2021/1602437 mechanisms. The research results showed that L. spinosa contains many important nutritional and phytochemical components such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence supports the fact that the plant has antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic, antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive. Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these data, L. spinosa can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in humans.
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    Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma
    (2021) Durna Daştan, Sevgi; jain, divya; Murti, Yogesh; Khan, Vasi Ullah; hossain, rajib; hossain, MOhammed Nabil; Agraval, Krish Kumar; Ashraf, Rana Azem; Islam, Muhammed toregul; Janmeda, Pracheta; tahari, yasaman; Al-shehri, Mohammed; Yeskaliyeva, balakyz; Kıpchakheyeva, aliyeva; Rad, Javad sharifi; Cho, William c
    Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives.