Biyoloji Bölümü Koleksiyonu
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Öğe Genel Hayvan Embriyolojisi(Sivas Cumhuriyet Üniversitesi, 2012) Akpınar, Mehmet Ali‘’Genel Hayvan Embriyolojisi (Omurgalılar)’’ adı altında yayınlanan bu kitap, Biyoloji Lisans öğrencilerinin yararla nabilecekleri bir kaynak olarak hazırlanmıĢtır. Kitabın hazırlanmasında, oldukça karmaĢık ve anlaĢılması zor olan, tek hücreden baĢlayarak ergin bireye benzer bir organizmanın meydana geliĢini ve bu geliĢim sırasında görülen önemli değiĢiklikleri genel olarak fazla detaya inmeden sunmak amaçlanmıĢtır. Biyoloji Lisans öğrencisi iken, bana embriyolojiyi sevdiren ve hoĢ anlatımıyla konuları ilginç hale getiren emekli Prof. Dr. Süheyla KüçükekĢi’ye teĢekkürü borç bilirim. Öğrencilik yıllarımda embriyolojiye duyduğum ilgi ve edinmiĢ olduğum bilgi 1985 yılında Cumhuriyet Üniversitesi Fen-Edebiyat Fakültesi Biyoloji Bölümünde bu dersi vermeme neden olmuĢtur. Bu yıldan itibaren de bu dersi Biyoloji öğrencilerine severek vermekteyim. Bu kitabın temelini gerek Prof. Dr. Süheyla KüçükekĢi’den edindiğim bilgiler gerekse bu konuda yayınlanmıĢ eserler oluĢturmaktadır. Eserlerinden faydalandığım bilim emekçilerine ayrıca teĢekkür ederim. Bu kaynaklar ıĢığında öğrencilerimize embriyoloji dersinde sunduğum bilgilerin, daha yararlı olması amacıyla ders kitabı Ģeklinde hazırlanması gereksinimi doğmuĢtur. Bu kaynak kitabın tüm Biyoloji öğrencilerine yararlı olmasını diler, gösterilen özene rağmen gözden kaçan bazı hataların ve eksikliklerin okuyucular tarafından hoĢ görüyle karĢılanacağını umarım. Bu konuda gelecek olan yapıcı eleĢtiriler beni memnun edecektir...Öğe Genel Hayvan Embriyolojisi(Sivas Cumhuriyet Üniversitesi, 2007) Akpınar, Mehmet Ali"Genel Hayvan Embriyolojisi (Omurgalılar)" adı altında yayınlanan bu kitap, Biyoloji Lisans öğrencilerinin yararlanabilecekleri bir kaynak olarak hazırlanmıştır. Kitabın hazırlanmasında, oldukça karmaşık ve anlaşılması zor olan, tek hücreden başlayarak ergin bireye benzer bir organizmanın meydana gelişini ve bu gelişim sırasında görülen önemli değişiklikleri genel olarak fazla detaya inmeden sunmak amaçlanmıştır. Biyoloji Lisans öğrencisi iken, bana embriyolojiyi sevdiren ve hoş anlatımıyla konuları ilginç hale getiren emekli Prof. Dr. Süheyla Küçükekşi'ye teşekkürü borç bilirim. Öğrencilik yıllarımda embriyolojiye duyduğum ilgi ve edinmiş olduğum bilgi 1985 yılında Cumhuriyet Üniversitesi Fen-Edebiyat Fakültesi Biyoloji Bölümünde bu dersi vermeme neden olmuştur. Bu yıldan itibaren de bu dersi Biyoloji öğrencilerine severek vermekteyim. Bu kitabın temelini gerek Prof. Dr. Süheyla Küçükekşi'den edindiğim bilgiler gerekse bu konuda yayınlanmış eserler oluşturmaktadır. Eserlerinden faydalandığım bilim emekçilerine ayrıca teşekkür ederim. Bu kaynaklar ışığında öğrencilerimize embriyoloji dersinde sunduğum bilgilerin, daha yararlı olması amacıyla ders kitabı şeklinde hazırlanması gereksinimi doğmuştur.Öğe Chemical and functional composition and biological activities of Anatolian Hypericum scabrum L. plant(2023) Durna Daştan, SevgiHypericum scabrum L. plant has wide use in ethnopharmacology and is cultivated both naturally and technologically. This study was conducted to determine chemical and functional properties and in vitro biological activities as antimicrobial, antioxidant, anticancer composition of H. scabrum L. (Hypericaceae) from Anatolia. This plant was collected from Elazıg and Sivas province of Turkey. The ICP-OES method was used for the investigation of the heavy metal composition and GC–MS analysis was used for the defining of chemical components. Antimicrobial qualifications of plant extracts were investigated on 8 different microorganisms by minimum inhibition concentration (MIC) method. Antioxidant activities were inves- tigated by using Diagnostic kits, which provide 99% reliable results with chemical reduction reactions. In vitro anticancer properties of the extracts were investigated on 5 different cell lines by using MTT method. It was observed that the flower and leaf parts of Hypericum plant have a very high antioxidant capacity and has mediocre antimicrobial activity only on 2 microorganisms. Also moderate cytotoxic ac- tivities on some cell lines were determined. It is thought that H. scabrum plant has functional bioactive compounds and might be anÖğe Future of the Plant Biotechnology and Conservation of Plant Genetic Sources(2023) Durna Daştan, SevgiBitki genetik kaynaklarının korunması, biyoçeşitliliğin sürdürülmesi ve genetik çeşitliliğin gelecek nesiller için devam ettirilmesi açısından kilit bir öneme sahiptir. Önerilen stratejiler, in situ ve ex situ koruma çabalarını bütünlük içinde birleştiren, yeni teknolojileri kullanan ve koruma stratejilerinde genetik çeşitliliği, bağlantıyı ve sürdürülebilirliği vurgulayan bütünlükçü, disiplinler arası bir yaklaşımı içerir. İn situ koruma çabaları, bir türün ve onun genlerinin doğal yaşama ortamlarında korunmasını, rasgele eşeyli üreme sonuçlarını entegre ederek, ve genetik temsilciliği artırmak için detaylı örnekleme yapılmasını ve yeni bireylerin eklenmesini gerektiren bir süreci içerir. Bu stratejiler, genetik erozyonla mücadele etmek ve sürdürülebilir tarımı teşvik etmek için temel öneme sahiptir ve Birleşmiş Milletler Sürdürülebilir Kalkınma Hedefi 2.5’e uygun olarak tarımsal biyoçeşitlilik ve gıda güvenliği üzerine odaklanmaktadır. Bitki türleri için “Reintroduction; yeniden tanıtma” biyolojisinin, biyoçeşitliliğin korunması için temel bir araç olarak kurulması ve “reintroduction” çabalarında genetik çeşitliliğin öneminin, gelecekteki bitkisel çeşitliliği koruma çabalarını şekillendirmesi beklenmekteÖğe Collaborative Clinical Research on Metabolomics(2023) Durna daştan, SevgiCollaborative Clinical Research on MetabolomicsÖğe Öğe CA18101 towardsCA18101 - SOURDOugh biotechnology network towardsnovel, bIoproCesseSnovel, healthier and sustainable food and bIoproCesseS(SOURDOmICS)(SOURDOmICS)(2023) Durna Daştan, SevgiCA18101 towardsCA18101 - SOURDOugh biotechnology network towardsnovel, bIoproCesseSnovel, healthier and sustainable food and bIoproCesseS(SOURDOmICS)(SOURDOmICS)Öğe 121S953 numaralı ve "Sıçan Peritoneal Endometriozis Modelinde Metformin Ve Otx008?In Etkisi: Galektin Ve Sinsitinlerin Payı" başlıklı(2023) Durna daştan, Sevgi121S953 numaralı ve "Sıçan Peritoneal Endometriozis Modelinde Metformin Ve Otx008?In Etkisi: Galektin Ve Sinsitinlerin Payı" başlıklı Tubitak 1002Öğe 221S049 numaralı ve "Sıçan Batın içi Endometriozis Modelinde VEGFR1-3 Kinaz İnhibitörü Frukuintinibin Etkisi: VEGF/VEGFR ve Hippo-Yap Moleküllerinin Rolü" başlıklı(2023) Durna daştan, sevgi221S049 numaralı ve "Sıçan Batın içi Endometriozis Modelinde VEGFR1-3 Kinaz İnhibitörü Frukuintinibin Etkisi: VEGF/VEGFR ve Hippo-Yap Moleküllerinin Rolü" başlıklı TUBİTAK 1002 PROJESİÖğe Investigation of gene expression levels in thyroid tissues of rats treated with Wi-Fi electromagnetic wave (2.4–3 GHz Wi-Fi RF-EMF)(2023) Sevgi Durna DaştanA B S T R A C T In this study, it was aimed to examine the effects of wireless waves applied to rats in the thyroid tissue by evaluating gene expression levels on 12 determined gene regions. 20 healthy 16-week-old Wistar albino female rats weighting 200–220 g were used. In the experiments, two groups, control and experimental groups, were formed, and ten female rats were used in each group. While WI-FI electromagnetic field was applied to the experimental group of these rats, nothing was applied to the control group. Many different gene regions, including beta catenin, beta-actin, GAPDH, L3B, HIF 1-Alpha, GSk-3B, TCF, WNT7a, WNT10a, WNT2, Beclin 1 and Beclin 2, ATG5 and ATG12, were investigated. ACTB and GAPDH gene primers were used as a house keeping gene. The fold change values were calculated statistically from the data obtained from the gene expression results. Compared to the control group, it was observed that the experimental group had significant increases in gene expression levels of many gene regions investigated in the study (P<0.05). Among the study groups, 12 different genes such as beta catenin, beta-actin, GAPDH, L3B, HIF 1-Alpha, GSk-3B, TCF, WNT7a, WNT10a, WNT2, Beclin 1 and Beclin 2, ATG5 and ATG12, which we have determined according to the literature, are known to be related to autophagy and oxidative stress. When the expression levels were investigated, it was determined that the expression coefficients of all the genes studied in the wnt/ß catenin pathway in the experimental group of rats exposed to the Wi-Fi EMÖğe Phylogenetic analysis of Prunus genus using nuclear and chloroplast gene markers as a bioorganic structure profiling. Abdulrahman SS; Dastan SD; Shahbaz SE; Selamoglu Z. 2023. Journal of Molecular structure, 2023, 1284 DOI10.1016/j.molstruc.2023.135300(2023) Sevgi Durna DaştanPrunus species are known as model species for the family Rosaceae and other woody plants with their small genome size and relatively small life cycle as woody plants. Also Prunus species are economically important plants in the subfamily A mygdaloideae of the Rosaceae have a controversial taxonomic history due to the lack of a phylogenetic framework. Therefore, mapping, classification, determination the ge- netic structure and characterization of genes as a spesific chemical and fuctional units of nucleic acids and making phylogenetic analysis in these species have important implications. The aim of this study to find any gene markers as a bioorganic –chemical structure profiling to determine genetic diversity of dif- ferent Prunus species from Iraq by using nuclear and chloroplast DNA markers to evaluate the phylogeny of Prunus. A total of 12 species Prunus subgenus amygdalus were collected from Iraq. Ten gene region markers on both nuclear DNA and chloroplast DNA have been tested to evaluate the genetic variation at their molecular levels by using multiplex PCR with 10 gene region primers and sequence analysis for matK. The name of the gene regions using in this study are ITS (ITS1 + ITS2 + 5.8S coding region), rbcL, matK, rpl16, trnL-trnF, atpB-rbcL, rp136-infA-rps8, trnK-rps16, pbsM-trnD, psbA-trnH. As a result, five dif- ferent phylogenetic trees were obtained from the gene sequences of the samples and the base sequences were close to each other. The estimated value of the shape parameter for the discrete Gamma Distribu- tion is 0.05. The nucleotide frequencies are A = 29.41%, T/ U = 37.37%, C = 17.52%, and G = 15.67%. The nucleotide diversity of the sequenceÖğe 221S041 numaralı ve "Monometil Fumarat ve Nifedipin Sıçan Yumurtalığında İskemi Reperfüzyon Hasarını Azaltabilir Mi ve Bunda Oksidatif Strese Duyarlı Transkripsiyon Faktörleri Hif-1alfa, Nf-Kb ve Nrf2'nin Payı Nedir?"(2023) Durna daştan, sevgi221S041 numaralı ve "Monometil Fumarat ve Nifedipin Sıçan Yumurtalığında İskemi Reperfüzyon Hasarını Azaltabilir Mi ve Bunda Oksidatif Strese Duyarlı Transkripsiyon Faktörleri Hif-1alfa, Nf-Kb ve Nrf2'nin Payı Nedir?" başlıklı TUBİTAK 1002 projesiÖğe 221S041 numaralı ve "Monometil Fumarat ve Nifedipin Sıçan Yumurtalığında İskemi Reperfüzyon Hasarını Azaltabilir Mi ve Bunda Oksidatif Strese Duyarlı Transkripsiyon Faktörleri Hif-1alfa, Nf-Kb ve Nrf2'nin Payı Nedir?"(2023) Durna Daştan, Sevgi221S041 numaralı ve "Monometil Fumarat ve Nifedipin Sıçan Yumurtalığında İskemi Reperfüzyon Hasarını Azaltabilir Mi ve Bunda Oksidatif Strese Duyarlı Transkripsiyon Faktörleri Hif-1alfa, Nf-Kb ve Nrf2'nin Payı Nedir?" başlıklı TUBİTAK 1002 PROJESİÖğe 221S041 numaralı ve "Monometil Fumarat ve Nifedipin Sıçan Yumurtalığında İskemi Reperfüzyon Hasarını Azaltabilir Mi ve Bunda Oksidatif Strese Duyarlı Transkripsiyon Faktörleri Hif-1alfa, Nf-Kb ve Nrf2'nin Payı Nedir?" Başlıklı Tubitak 1002(2023) Durna Daştan, Sevgi221S041 numaralı ve "Monometil Fumarat ve Nifedipin Sıçan Yumurtalığında İskemi Reperfüzyon Hasarını Azaltabilir Mi ve Bunda Oksidatif Strese Duyarlı Transkripsiyon Faktörleri Hif-1alfa, Nf-Kb ve Nrf2'nin Payı Nedir?" Başlıklı TUBİTAK 1002 projesiÖğe Epigenetics: Beyond the genetics and medicine(Nova Science publishers, 2022) Durna daştan, sevgiEpigenetics refers to the study of changes in organisms that are caused by modifications of gene expression instead of alteration of the genetic code itself. This volume includes 30 chapters that explore epigenetics from a variety of perspectives, including the role of epigenetics in aging, cancers, fetal brain development, epilepsy, and more. Chapter 1 - Epigenetics is termed as non-sequence deoxyribonucleic acid (DNA) alterations in the gene expression profile that is heritable. With these, cellular identity is preserved, and gene function is transferred from one cell to another. Epigenetic changes occur with the effect of DNA methylation, chromatin structure changes, and non-coding ribonucleic acids, histone modifications. EÖğe Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective(biomed research international, 2022) Durna Daştan, SevgiDiabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/ MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of thesÖğe The role of Tumour Necrosis Factor in neuroinflammation associated with Parkinson's disease and targeted therapies(neurochemistry international, 2022) Durna Daştan, SevgiNeurodegenerative disorders Parkinson’s disease is a progressive neurodegenerative disorder associated with neuroinflammatory responses that lead to the neurodegeneration of the dopaminergic neurons. These neuroinflammatory mechanisms involve various cytokines produced by the activated glial cells. Tumour Necrosis factor α (TNF α) is one of the major mediators of the neuroinflammation associated with neurodegeneration. TNF α has a dual role of neuroprotection and neurotoxicity in the brain. The effective pathways of TNF involve various signalling pathways transduced by the receptors TNFR1 and TNFR2. Effective therapeutic strategies have been produced targeting the neurotoxic behaviour of the Tumour Necrosis Factor and the associated neurodegeneration which includes the use of Dominant Negative Tumour Necrosis Factor (DN-TNF) inhibitors like XENP 345 and XPro®1595 and peroxisome proliferator receptor gamma (PPAR-γ) agonistÖğe Cytokines and Diseases(Nova science publisher, 2022) Durna Daştan, Sevgiof different clinical pictures and diseases in the light of current information obtained from the literature. This book aims to describe the type, effects, and kinetics of cytokine production, as well as to summarize the pathophysiology of the cytokine storm that occurs after bacterial sepsis or severe viral infection. It has been a summative review containing the most up-to-date data for academics participating in cytokine-based therapy studies, studies targeting cytokine production or effects, and clinical trials that arouse interest after the Covid-19 pandemicÖğe A Review on Tradescantia: Phytochemical Constituents, Biological Activities and Health-Promoting Effects(Frontiers in Bioscience landmark, 2022) Durna Daştan, SevgiTradescantia is a genus of herbaceous and perennial plants belonging to the Commelinaceae family and organized into three infrageneric classifications and 12 sections. More than 80 species within the genus have been used for centuries for medicinal purposes. Phytochemical compounds (from various species of the genus) such as coumarins, alkaloids, saponins, flavonoids, phenolics, tannins, steroids and terpenoids have recently been characterized and described with antioxidant, cytotoxic, anti-inflammatory, anticancer or antimicrobial properties. The objective of this review is to describe the different aspects of the genus Tradescantia, including its botanical characteristics, traditional uses, phytochemical composition, biological activities, and safety aspects.Öğe Biosynthesized silver nanoparticles and miR34a mimics mediated activation of death receptor in MCF-7 human breast cancer cell lines(cancer nanotechnology, 2022) Durna Daştan, SevgiAbstractNano-biotechnology-based clinical applications to cure health-related issues have gained huge attention among the scientific community and hold great promise to limit cancer metastasis. In this study, green-derived silver nanoparticles were synthesized by using leaf extract of Litchi chinensis. Characterization of biosynthesized silver nanoparticles was performed by using UV–Vis spectroscopy, FTIR, XRD, EDS, and SEM analysis. The clinical application of green-drive nanoparticles was investigated by using MCF-7 cancer cell lines. MCF-7 breast cancer cell lines were analyzed against three different treatments. (i) Silver nanoparticles (AgNPs), (ii) miR34a mimics and (iii) Co-delivery of AgNPs and miR34a mimics. Cell viability was determined by MTT assay and, extraction of mRNA and cDNA synthesis were performed after successful cellular transfection. qRT-PCR was done for expression analysis of DR4 and DR5 upon exogenous delivery of all 3 treatments. Results indicate that L. chinensis leaves have a significant amount of phenolic and flavonoid contents and also possess massive antioxidant activity. The diameter of nanoparticles was observed in the range of 41–55 nm. It was concluded that green-derived silver nanoparticles can be a potential contributing agent for cancer prevention and are reported to upregulate the expression of DR4 and DR5 by 0.8-folds and 3.7-folds, respectively.
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