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Öğe How can we increase adherence to medical treatment in heart failure patients? A questionnaire study(Wiley, 2024) Kaya, H. Hakki; Sahin, A.; Aksit, E.; Yilmaz, M. B.[No abstract available]Öğe A Fluorescent Aptasensor for Sensitive and Selective Determination of Epigenetic Cancer Biomarker N1-Methyladenosine in Urine Samples(Wiley-V C H Verlag Gmbh, 2025) Bagda, Esra; Bagda, Efkan; Liu, JuewenN1-methyladenosine (m1A) level in urine increases in the presence of cancer and is associated with the tumor size and stage. In the present study, we aimed to develop a method for rapid, sensitive and accurate determination of m1A in urine samples. The capture systematic evolution of ligands by exponential enrichment (SELEX) method was used to isolate aptamers that could selectively bind to m1A. We successfully isolated two sequences that have high selectivity toward m1A. The affinities against m1A were determined by isothermal titration calorimetry (ITC) and thioflavin T (ThT) assays. The N1MA1a aptamer has a Kd of 1.9 +/- 0.1 mu m determined by the ThT assay and 0.75 +/- 0.04 mu m determined by ITC. A strand-displacement biosensor was designed by labeling the aptamer with a carboxy fluorescein (FAM) and hybridizing it with a quencher-labeled complementary DNA strand. Using this biosensing system, m1A was detected with a detection limit of 1.9 mu m. The system shows high selectivity to m1A and high tolerance to adenosine, cytidine, guanosine, thymidine, uridine and N6-methyladenosine (m6A) as well as urine constituents at their real levels in urine. The sensor has been applied to five different human urine samples showing quantitative recovery values, which indicates practical potential of this aptamer-based biosensor.Öğe ( α,β )- TYPE ALMOST η-RICCI-YAMABE SOLITONS IN PERFECT FLUID SPACETIME(Comenius Univ, Sch Medicine, 2024) Pandey, S.; Mert, T.; Atceken, M.In this paper, we consider perfect fluid spacetime admitting (alpha, beta)type almost eta-Ricci-Yamabe solitons by means of some curvature tensors. Ricci pseudosymmetry concepts of perfect fluid spacetime admitting (alpha, beta)-type almost eta-Ricci-Yamabe soliton are introduced according to the choice of some special curvature tensors such as Riemann, concircular and projective curvature tensor. After then, according to choosing of the curvature tensors, necessary conditions are given for perfect fluid spacetime admitting (alpha, beta)-type almost eta-Ricci-Yamabe soliton to be Ricci semisymmetric. Then, some important characterizations are given for Ricci, Yamabe, Einstein and eta-Einstein solitons on perfect fluid spacetime.Öğe The Effects of Sunitinib in Healthy and Cisplatin-Induced Rats(Wiley-V C H Verlag Gmbh, 2023) Demirtas, Levent; Gurbuzel, Mehmet; Akbas, Emin Murat; Tahirler, Hilal; Karatas, Ozhan; Arslan, Yusuf KemalSunitinib is a multitargeted kinase inhibitor that inhibits many receptor tyrosine kinases and has been used in the treatment of gastrointestinal stromal tumors, metastatic renal cell carcinoma, and pancreatic neuroendocrine tumors. In this study, the effects of sunitinib given to rats, both alone and after stress with cisplatin, were investigated. The animals were divided into four groups - (1) control group (C) administered interperitoneally with a single dose 0.9 % saline, (2) Cis group administered a single dose (7 mg/kg) of cisplatin, (3) Sun group administered 10 mg/kg sunitinib for seven days, and (4) Cis+Sun group administered 10 mg/kg sunitinib for seven days after a single dose (7 mg/kg) of cisplatin. After these applications, the rats were sacrificed, and blood and tissue samples were taken for biochemical and histopathological evaluations. Sunitinib did not show any effect on urea, creatine, and kidney IL1 beta and TGF-beta 3 expression levels when administered alone; it increased ALT, AST, and IL-38 levels. When sunitinib was given to the cisplatin-induced rats, it was observed that the increase in ALT, AST, and IL-38 levels increased more than the rats that was given only sunitinib. According to the data obtained, sunitinib does not cause a significant change in kidney tissue under both normal and stress conditions, while it creates stress in liver tissue. In addition, its toxicity in the liver becomes more certain as a result of its combination with cisplatin.Öğe Deciphering mortality risk of antidiabetic medications in well-treated heart failure patients with diabetes mellitus(Wiley, 2024) Colluoglu, I. T.; Celik, A.; Ata, N.; Ural, D.; Sahin, A.; Ulgu, M. M.; Kanik, A.[No abstract available]Öğe Interaction of cumulus-oocyte complex (coc) number, oocyte quality, and blastocyst numbers by repeated ovum pick-up (opu) in in vitro embryo production(Chulalongkorn Univ, 2024) Ulkum, C. I. Z. M. E. C. I. Sakine; Ali, D. I. N. C. Dursun; Numan, B. U. C. A. K. Mustafa; Faruk, Y. E. S. I. L. K. A. Y. A. Omer; Furkan, Muhammed; Bugra, K. I. V. R. A. K. Mehmet; Ayse, SariOvum pick-up (OPU) is a repeatable technique that is used for the retrieval of large numbers of immature oocytes from the antral follicles of live animals. The aim of the present study was to determine the effect of repeated OPU application on cumulus-oocyte complex (COC) number, oocyte quality, and blastocyst rates. The animal material for the study consisted of 10 Holstein heifers. Heifers selected as donors were administered OPU a total of 9 times on random days of the cycle at 1-week intervals. All antral follicles with a diameter of 2-8 mm were aspirated during the OPU procedure. In vitro embryo production (IVEP) was performed on the oocytes obtained after quality assessment. Various degrees of adhesion and connective tissue thickening were found in the ovaries of the animals after 9 repeated applications of OPU. It was found that the average number of A-quality oocytes was higher than the number of B, C, and D-quality oocytes. The number of cleavages per OPU was 2.69 (cleaved oocytes/opu session), and the number of blastocysts was 0.72 (number of blastocysts/opu session). It was determined that the general average of cleavage ratios was 73.62%, and blastocyst rates were 18.97%. It was observed that the number of oocytes, cleavage, and blastocysts obtained as a result of repeated OPU applications was not affected by repeated OPU. It was concluded that in order to achieve the target number of oocytes and blastocysts with recurrent OPU, experiments should be carried out with varying frequencies of OPU, and prophylactic measures should be taken to prevent adhesions.Öğe New benzimidazole derivatives containing hydrazone group as anticancer agents: Inhibition of carbonic anhydrase IX and molecular docking studies(Wiley-V C H Verlag Gmbh, 2025) Bostanci, Hayrani Eren; Yildiz, Mehmet Taha; Kapancik, Serkan; Inan, Zeynep Deniz Sahin; Kilic, Haci Ahmet; Guler, Ozen Ozensoy; Cevik, Ulviye AcarIn this study, we propose identifying potential novel compounds targeting carbonic anhydrase (CA) IX and anticancer activity. To study the impact of these synthesized compounds on CA IX and anticancer activity, we have developed and synthesized novel benzimidazole-hydrazone derivatives (3a-3j). The target compounds' H-1 NMR (nuclear magnetic resonance), C-13 NMR, and high resolution mass spectrometry spectra were used to confirm their chemical structures. L929 (healthy mouse fibroblast cell line) used as control healthy cell line and MCF-7 (breast cancer), C6 (rat glioblastoma), HT-29 (colon cancer), cells were used in cell culture studies. As a result of cell culture studies, it was determined that the newly synthesized compounds 3d and 3j had cytotoxic effects on colon cancer. Again, it was determined that the compound 3d had a more toxic effect than cisplatin on both breast cancer and glioma cells. According to the CA IX activity results, compounds 3d and 3j were found to have the highest activity. Compounds 3d and 3j are essential for having anti-cancer properties and inhibiting the carbonic anhydrase IX enzyme. Molecular docking of these compounds was carried out in the active site of CA IX. Flow cytometry and immunofluorescence microscope analyses also confirmed that these compounds had cytotoxic effects on cancer cells.Öğe A proposal forthe etymology of Turkic yarγak(Harrassowitz Verlag, 2024) Ayazli, OzlemThe paper aims to establish anetymology of yar gamma ak, first attested in the 14th century, based on data from several Turkic languages. While in older Turkic languages the term has meanings such as 'untanned leather', 'the leather fur worn by the Mongols', 'leather robe/clothing', in modern Turkic languagesit survives with meanings such as 'untanned leather', 'membrane', 'film', 'tanned leather', 'fur from foal skin or lambskin', 'tannedsheepskin or goatskin', 'dried skin', 'dried scab'. In addition, it is used metaphorically with meanings such as 'thin', 'skinny'; 'bare', 'bald', etc. in modern Turkic languages. The word has earlier been derived from*yar gamma a-, yaru-'to shine'. The proposals put for-ward in this study are as follows: 1. The origin of the word must beyari membrane', 'film', 'tanned leather', which is attested in older and modern Turkic languages: yari+gamma ak> yar gamma akwith vowel elision. 2. Based on the forms Middle Turkicyari gamma'leather strap',Altaykari gamma'untanned leather',and Yakutsariy'membrane', 'deerskin', the word must be connected with Proto-Turkic *yar & iuml;gamma< *yari gamma+ak. Furthermore, yar gamma akis derived with the denominal nominal suffix +gamma ak/+ak.Öğe Density Functional Theory Computations and Experimental Analyses to Highlight the Degradation of Reactive Black 5 Dye(Wiley-V C H Verlag Gmbh, 2023) Yildiz, Sayiter; Canbaz, Gamze Topal; Kaya, Savas; Maslov, Mikhail M.The oxidative degradation of Reactive Black 5 (RB5) in aqueous solution was investigated using Fenton (FP), photo Fenton (P-FP), sono Fenton (S-FP), and sono photo Fenton (S-P-FP) processes. Degradation experiments showed efficient dye degradation for FP, P-FP, S-FP, and S-P-FP under optimal conditions. The half-life values of the reaction calculated for first-order reaction kinetics showed that the S-FP process is faster than the FP and P-FP processes. Using DFT calculations, the chemical reactivities of the studied chemical systems were analyzed. Especially the calculated chemical hardness values reflect the reactivities of the dye and the dye-Fe2+ complex. The calculated binding energy between the Fe2+ ion and RB5 of 15.836 eV is compatible with the prediction made in the light of the principle of hard and soft acids and bases. The computed data supported the experimental observations.Öğe Unlocking survival: assessment of potassium levels in heart failure with quadruple guideline directed medical therapy across all ejection fraction spectrum(Wiley, 2024) Yilmaz, M. B.; Colluoglu, T.; Sahin, A.; Ural, D.; Ata, N.; Celik, A.[No abstract available]Öğe Benzothiazole Derived Ether Hybrids as Potent Anti-Thymidine Phosphorylase Agents: Synthesis, In Vitro, and Computational Investigations(Wiley-V C H Verlag Gmbh, 2025) Usman, Muhammad; Alam, Aftab; Zainab; Khan, Majid; Tuezuen, Burak; Ayaz, Muhammad; Alanazi, Mohammed M.This work is based on the synthesis of new ether derivatives bearing benzothiazole (BTA) scaffold through multistep reaction process. Initially, BTA was prepared by refluxing 4-hydroxybenzaldehyde with aminothiophenol having sodium metabisulfite in dimethylformamide (DMF); subsequently, the product was further refluxed with different substituted benzyl and alkyl bromides in acetone to get ether hybrids of BTA in good yields. Structurally, these compounds were confirmed by means of 1H, 13C-NMR, and mass spectrometry and evaluated for in vitro thymidine phosphorylase (TP) inhibitory activity. In the series, seven compounds attributed excellent inhibition against TP enzyme better than the standard. Similarly, three compounds showed good activity, whereas two compounds were found inactive. Moreover, all these compounds showed no toxicity to normal human fibroblast cell line (BJ cell line). In addition, Gaussian calculations were performed on the 6-31++g(d,p) basis set to examine the 13 synthesized compounds at the B3LYP, HF, and M062X levels. Additionally, molecular docking calculations were performed on TP enzyme proteins (PDB IDs: 4EAD, 2WK6, and 4LHM), and absorption, distribution, metabolism, excretion/toxicity (ADME/T) calculations were performed to investigate the effects and responses of these compounds in human metabolism.Öğe Evaluation of novel azomethine compound in genes involved in cell cycle and apoptosis in osteosarcoma cells(Wiley, 2024) Agbektas, T.; Pazarci, O.; Tas, A.; Huseynzada, A.; Guliyev, R.; Hasanova, U.; Silig, Y.[No abstract available]Öğe Impact of defibrillators on mortality in patients with quadruple guideline-directed medical therapy: a propensity score-matched study(Wiley, 2024) Sahin, A.; Celik, A.; Ural, D.; Colluoglu, I. T.; Ata, N.; Kanik, E. A.; Ulgu, M. M.[No abstract available]Öğe Synthesis, Biological Activities, DFT Calculations, and Molecular Docking Studies of O-Methyl-Inositols(Wiley-V C H Verlag Gmbh, 2025) Aksu, Kadir; Ayvaz, Melek col; Celik, Omer Faruk; Serdaroglu, Goncagul; Ustun, Elvan; Kelebekli, LatifThe concise synthesis of O-methyl-d-inositol derivative and conduritol derivatives was obtained starting from p-benzoquinone. Spectroscopic methods have been performed for the characterization of newly synthesized compounds. Cyclitols are useful molecules with anticancer, antibiotic, antinutrient, and antileukemic activities. Inositol class molecules, known as the most important cyclitol derivatives, were examined in this study for their 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide radical scavenging and butyrylcholinesterase (BChE) and glycosidase inhibition activities. It was observed that compound 5, in particular, showed efficacy that competed with the standards in terms of both antioxidant activity and enzyme inhibitor potential. Additionally, compound 5 shows effective antimicrobial activity. The water-soluble characteristics and lipophilic properties of the compounds were also considered and discussed. Moreover, the quantum chemical analyses were performed in light of the DFT/B3LYP/6-311G** level computations to elucidate/compare the studied inositols' possible reactivity directions. Additionally, the interactions of the molecules were analyzed against acetylcholinesterase (AChE), peroxiredoxin 5, and DNA gyrase by molecular docking methods. Cholinesterase inhibitors have an important status as the most important drug group used in the treatment of Alzheimer's disease today. Considering the effects of inhibition of the alpha-glucosidase enzyme by inhibitors, such molecules can also be used as therapeutic components in the treatment of diabetes.Öğe Novel Aminothiazole-Chalcone Analogs: Synthesis, Evaluation Acetylcholinesterase Activity, In Silico Analysis(Wiley-V C H Verlag Gmbh, 2025) Sarikaya, Meryem Kececi; Yildirim, Suheda; Kocyigit, Umit M.; Ceylan, Mustafa; Yirtici, Umit; Eyupoglu, VolkanIn this study, novel thiazole-chalcone analogs were synthesized, and their inhibitory effects on acetylcholinesterase (AChE) were examined. In vitro enzyme activity studies were conducted to calculate IC50 values, which were found to range between 2.55 and 72.78 mu M (tacrine IC50 = 53.31 mu M). The Ki values of the compounds showing the best inhibition (6g and 6e) were calculated and compared to those of the standard substance tacrine. All compounds reduced the AChE activity. Additionally, predictions made with SwissADME indicated that all compounds complied with Lipinski's rules and possessed good oral bioavailability properties, and the inhibitory effects of compounds 6e and 6g on AChE were evaluated using molecular docking and molecular dynamics simulations (100 ns). The results showed that compounds 6e and 6g had strong and stable interactions with AChE.Öğe Effect of varieties and growth stages at harvest on forage quality and nutritive values of Italian ryegrass ( Lolium multiflorum Lam. ssp. westervoldicum)(Scientific Issues Natl Centre Agrarian Sciences, 2024) Ozkose, Abdullah; Acar, Ramazan; Inal, Fatma; Alatas, Mustafa Selcuk; Kahraman, Oguzhan; Ozbilgin, AbdullahThe effects of harvesting periods and cultivars on the nutritional values of forage crops are very important. In the present study, the effects of harvesting periods and varieties on the nutritional values of Italian ryegrass were investigated. The trial was conducted in the Randomized Complete Block Design with four replications under the environmental conditions of Central Anatolia in the growing season of 2015. Seven Italian ryegrass varieties were harvested at two different harvest times in the study (earing and dough forming period) and feed values were determined. As a result of the study, the crude protein content of Italian ryegrass was found to be 9.4 - 21.0%, crude ash was 0.22% - 0.48%, crude fat 0.11% - 0.26%, ADF 30.45 - 36.26%, NDF 49.99% - 57.11%, ADL 7.72 - 10.11%, TDN 49.31% - 53.55%, ME 1.68 - 1.86 Mcal/kg, NEL 0.99 - 1.12 Mcal/kg, NEM 0.87 - 1.04 Mcal/kg, and NEG 0.31 - 0.48 Mcal/kg compared to the beginning of earing and dough formation period. According to the statistical analysis results, the differences between variety averages, growth period averages, and cutting averages were found to be significant in terms of the analyzed characteristics (crude protein, crude fat, crude ash, ADF, NDF, ADL, TDN, ME, NEL, NEM, and NEG). According to the results of the present study, it is recommended to cut at the beginning of the heading to obtain quality grass in Italian ryegrass farming. It is also very important to choose the appropriate Italian ryegrass variety for each region.Öğe The relationship between serum sodium variability and survival in heart failure patients: results from TRends-HF(Wiley, 2024) Murat, S. Selda; Cavusoglu, Y.; Sahin, A.; Colluoglu, I. T.; Celik, A.; Yilmaz, M. B.[No abstract available]Öğe Hyponatremia is highly prevalent and associated with worse clinical outcomes in HF population in Turkiye: results from TRends-HF(Wiley, 2024) Murat, S. Selda; Cavusoglu, Y.; Sahin, A.; Colluoglu, I. T.; Celik, A.; Yilmaz, M. B.[No abstract available]Öğe Research and product development for Crimean-Congo haemorrhagic fever: priorities for 2024-30(Elsevier Sci Ltd, 2025) Semper, Amanda E.; Olver, Janie; Warner, Jenny; Cehovin, Ana; Fay, Petra C.; Hart, Peter J.; Golding, Josephine P.Crimean-Congo haemorrhagic fever (CCHF) is a widely distributed and potentially fatal tick-borne viral disease with no licensed specific treatments or vaccines. In 2019, WHO published an advanced draft of a research and development roadmap for CCHF that prioritised the development and deployment of the medical countermeasures most needed by CCHF-affected countries. This Personal View presents updated CCHF research and development priorities and is the product of broad consultation with a working group of 20 leading experts in 2023-24. The strategic goals, milestones, and timelines have been revised and expanded to reflect scientific advances since 2019, including the identification of antibodies with therapeutic potential and the progression of four vaccine candidates through phase 1 clinical trials. This update emphasises the need for a One Health approach to manage CCHF, from integrated crosssectoral surveillance to novel interventions that target ticks and their vertebrate hosts to reduce CCHF virus transmission to humans. The overarching vision for rapid diagnostics and specific therapeutics by 2028, followed by options to limit CCHF virus transmission and control disease by 2030, is deliberately ambitious and will only be achieved through coordinated international action from affected countries, funders, scientists, product developers, manufacturers, regulators, national authorities, and policy makers.Öğe The Impact of Multiple Sclerosis on Marriage and Divorce: Insights from A Multicenter Study in Turkey(Sage Publications Ltd, 2024) Ethemoglu, Ozlem; Gocmen, Adalet; Omerhoca, Sami; Kocaogullar, Alperen; Gokce, Seyda; Guzey, Rumeysa; Bunul, Sena Destan[No abstract available]
