The Effect of Rectal Ozone Use on Bacterial Translocation and Oxidative Stress in Experimental Colitis Model

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dc.contributor.authorBostancı, Meriç Emre
dc.contributor.authorAvcı, Onur
dc.contributor.authorTaş, Ayça
dc.contributor.authorKoç, Tülay
dc.contributor.authorGürsoy, Sinan
dc.contributor.authorSiliğ, Yavuz
dc.date.accessioned2025-05-04T16:20:56Z
dc.date.available2025-05-04T16:20:56Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The aim of this study was to examine the effect of rectal ozone on the histopathological healing of the colonic mucosa, tissue oxidative stress, and bacterial translocation in the experimental colitis model. Materials and Methods: Three groups of rats were randomly formed
dc.description.abstractMicroscopic and macroscopic scoring were done histopathologically in all groups. Glutathione-s-transferase (GST), superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) levels were measured in the colon and liver tissue. Blood cultures were taken for the detection of bacterial translocation. Results: Microscopic damage scores were found as 0.0 (0.0-2.0) in the sham group, 3.0 (3.0-3.0) in the control group, 2.0 (0.0-2.0) in the ozone treatment group (p=0.001). Macroscopic damage scores were found as 0.0 (0.0-1.0) in the sham group, 3.0 (0.0-4.0) in the control group, 0.0 (0.0-1.0) in the ozone treatment group; the scores of ozone treatment and sham groups were found to be statistically different (p=0.004). Compared to the control group, the bacterial translocation in the liver, mesenteric lymph node, portal vein, spleen, and systemic blood was fewer in the ozone treatment group. Statistically significant differences were also observed between the groups’ SOD and GST levels in colon tissue and MDA, SOD, and GST levels in liver tissue. Regarding MDA values in the liver tissue of the groups, it was 1.95±0.43 in Group I, 3.63±0.81 in Group II, and 1.19±0.72 U/mg in Group III (p=0.017). When the liver tissue SOD levels of the groups were examined, it was 8.21±0.76 U/mg in Group I, 4.57±0.58 U/mg in Group II, and 8.62±1.13 U/mg in Group III (p=0.029). When GST values in liver tissue belonging to the groups were examined, 0.35±0.16 in Group 1, 0.23±0.03 in Group II, 0.49±0.13 U/mg in Group III (p=0.036). Conclusion: Rectal ozone application plays a role in increasing the organism’s antioxidant activity and has an effective role in increasing the enzyme activities of antioxidant defenses. In addition, rectal ozone application has a positive effect on wound healing at a histopathological level and reduces bacterial translocation in various tissues.
dc.identifier.doi10.26650/experimed.1102002
dc.identifier.doihttps://doi.org/10.26650/experimed.1102002
dc.identifier.endpage73
dc.identifier.issn2667-5846
dc.identifier.issue2
dc.identifier.startpage66
dc.identifier.urihttps://hdl.handle.net/20.500.12418/31484
dc.identifier.volume12
dc.language.isoen
dc.publisherİstanbul Üniversitesi
dc.relation.ispartofExperimed
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectExperimental colitis
dc.subjectOxidative Stress
dc.subjectRectal ozone
dc.titleThe Effect of Rectal Ozone Use on Bacterial Translocation and Oxidative Stress in Experimental Colitis Model
dc.typeResearch Article

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