In Vitro Tyrosinase and Collagenase Inhibitory and Antioxidant Potential of Smyrnium rotundifolium Mill. and Euphorbia virgata Waldst.&Kit. from Türkiye

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dc.contributor.authorGürer, Eda Sönmez
dc.contributor.authorKaradağ, Ayşe Esra
dc.contributor.authorBaydar, Rengin
dc.contributor.authorDemirel, Melek
dc.date.accessioned2025-05-04T16:18:55Z
dc.date.available2025-05-04T16:18:55Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAntioxidants help prevent signs of aging and skin tone inequalities by protecting our skin from free radicals. High tyrosinase inhibition has a whitening effect on the skin, while collagenase inhibition has an anti-sagging effect on the skin. Antioxidant activity and tyrosinase/collagenase enzyme inhibition capacities have mutually supporting effects. The aim of this study was to determine the antioxidant activities, tyrosinase and collagenase inhibitory potentials of ethanol extracts of two medicinal plants from Turkey (Smyrnium rotundifolium and Euphorbia virgata). In the study, 6 different reference substances and their chemical contents were investigated. Myricetin, quercetin and kaempferol were observed in S. rotundifolium extract, and quercetin was observed in E. virgata extract. According to the antioxidant capacity results measured by both analyses; S. rotundifolium (IC50 DPPH•: 4.9±0.15 µg/mL, IC50 ABTS•+: 4.3±0.2 µg/mL) and E. virgata (IC50 DPPH•: 4.6±0.11 µg/mL, IC50 ABTS•+: 4.1±0.13 µg/mL) extracts were observed to have antioxidant capacities similar to each other. It was determined that S. rotundifolium had higher anti-collagenase (27.9±0.13% inhibition) and anti-tyrosinase (11.1±0.14% inhibition) activities compared to E. virgata extract. These results showed us that S. rotundifolium can be considered as a strong candidate for the management of epidermal hyperpigmentation and skin elasticity and deserves further study.
dc.description.abstract[No abstract available]
dc.identifier.doi10.17776/csj.1568111
dc.identifier.doihttps://doi.org/10.17776/csj.1568111
dc.identifier.endpage762
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue4
dc.identifier.startpage756
dc.identifier.urihttps://hdl.handle.net/20.500.12418/31164
dc.identifier.volume45
dc.language.isoen
dc.publisherSivas Cumhuriyet Üniversitesi
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectAntioxidant
dc.subjectCollagenase
dc.subjectEuphorbia virgata
dc.subjectSmyrnium rotundifolium
dc.subjectTyrosinase
dc.titleIn Vitro Tyrosinase and Collagenase Inhibitory and Antioxidant Potential of Smyrnium rotundifolium Mill. and Euphorbia virgata Waldst.&Kit. from Türkiye
dc.typeResearch Article

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