Investigation of The Effect of B-108 Contaınıng Azomethin Group On DNA Repair Gene

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dc.contributor.authorEğilmez, Elif
dc.contributor.authorZontul, Cemile
dc.contributor.authorHuseynzada, Alakbar
dc.contributor.authorAliyeva, Gunel
dc.contributor.authorHasanova, Ulviyya
dc.contributor.authorTaş, Ayça
dc.contributor.authorSiliğ, Yavuz
dc.date.accessioned2025-05-04T16:26:30Z
dc.date.available2025-05-04T16:26:30Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Cancer arises as a result of the failure of the mechanisms controlling normal division in a group of cells. It is known that some new synthesis compounds intended for use in cancer treatment have anti-fungal, anti-bacterial, anti-carcinogenic effects. In this study, it was aimed to apply the newly synthesized B-108 compound to the A-549 cell line and then to investigate the effect of this compound on the ERCC1 gene expression profile. Materials and Methods: Firstly, compound B-108 was synthesized in our study. Afterwards, this synthesized molecule was applied in eight different concentrations (1-100 μg/ml) in A-549 cell line and 3-(4,5-dimethylthiazol-2-yl)-2,5-yl for 24 hours, 48 hours and 72 hours. Anticancer activities were determined using diphenyltetrazolium bromide (MTT) method. Expression level of DNA repair gene (ERCC1) was determined using RT-PCR method. Results: As a result, it was determined that the molecule applied to the A-549 cell line showed the highest activity after 72 hours of incubation. It was observed that the ERCC1 gene expression of the molecule applied on lung cancer was lower than the control group. Discussion: Considering the current study results, low expression of ERCC1 shows that compound B-108 correlates with overall survival on lung cancer cells.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.1189765
dc.identifier.doihttps://doi.org/10.7197/cmj.1189765
dc.identifier.endpage342
dc.identifier.issn1305-0028
dc.identifier.issue4
dc.identifier.startpage338
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32763
dc.identifier.volume44
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectAzomethine Grup
dc.subjectLung cancer
dc.subjectDNA Repair
dc.subjectGene Expression
dc.titleInvestigation of The Effect of B-108 Contaınıng Azomethin Group On DNA Repair Gene
dc.typeResearch Article

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