The Healing Effect of Resveratrol and Platelet Rich Plasma in Corrosive Esophagitis Model in Rats

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dc.contributor.authorÖzden, Hüseyin
dc.contributor.authorGömeç, Muhammed
dc.contributor.authorŞahin, Yaşar
dc.contributor.authorKaraca, Gökhan
dc.contributor.authorBulut, Huri
dc.contributor.authorKilitci, Asuman
dc.date.accessioned2025-05-04T16:26:29Z
dc.date.available2025-05-04T16:26:29Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Corrosive esophageal burns have high morbidity and mortality. The effective treatment is controversial. In our study, we aimed to examine the effects of resveratrol (RSV) and platelet rich plasma (PRP) on healing in the corrosive esophagitis model in rats. Material and methods: A total of 24 rats were randomly divided into 4 groups each as esophagitis, control, PRP and RSV groups. No treatment was administered to the control group. The esophagitis model was induced in the esophagitis and treatment groups. The esophagitis group was not treated. PRP group was treated with PRP, RSV group was treated with RSV. Pathological and biochemical examinations were performed from distal esophagitis. Results: The highest tissue IL-1, IL-6, and TNF-α levels were observed in the esophagitis group. The lowest tissue IL-1, IL-6, and TNF-α levels were noted in the control group. The highest tissue TAS levels were observed in the control group. The lowest tissue TAS levels were noted in the esophagitis group. The other groups had significantly lower mean tissue TOS and OSI levels than the esophagitis group (P<0.05). Conclusions: PRP and RSV have a healing effect on esophagitis. We are of the opinion that it may be included in clinical practice over time if the dose and duration of treatment can be adjusted better for RSV.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.1149750
dc.identifier.doihttps://doi.org/10.7197/cmj.1149750
dc.identifier.endpage287
dc.identifier.issn1305-0028
dc.identifier.issue3
dc.identifier.startpage282
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32750
dc.identifier.volume44
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectAntioxidant
dc.subjectesophagitis
dc.subjectoxidant
dc.subjectplatelet rich plasma
dc.subjectresveratrol
dc.titleThe Healing Effect of Resveratrol and Platelet Rich Plasma in Corrosive Esophagitis Model in Rats
dc.typeResearch Article

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