Effect of captopril on the oxidative damage caused by pentylenetetrazole in the SHSY-5Y human neuroblastoma cell line

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dc.contributor.authorDoğan, Murat
dc.contributor.authorKarademir, Mustafa
dc.date.accessioned2025-05-04T16:26:40Z
dc.date.available2025-05-04T16:26:40Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Epilepsy is a crucial brain disorder that seizures could cause a neuronal loss in the hippocampus. Oxidative stress has an important role in the pathology of this way. The aim of this study was to investigate the neuroprotective effect of captopril, on pentylenetetrazole (PTZ) induced epileptic seizures in SH-SY5Y cell line. Method: In this XTT cell viability assay, captopril was performed in vitro SH-SY5Y cell culture to evaluate PTZ-induced neurotoxicity. Tissue TOS concentrations at the cell supernatants were quantified with the automated assay method. Hydrogen peroxide was used for the calibration of the assay.Results: When XTT cell viability results were evaluated, captopril did not affect neuronal viability in SH-SY5Y cell line. Moreover, captopril did not have significant effect on TOS levels (***P>0. 001)Conclusions: Results showed that, captopril did not have neuroprotective properties in SH-SY5Y cell line after PTZ-induced neurotoxicity.
dc.description.abstract[No abstract available]
dc.description.sponsorshipSivas Cumhuriyet University, School of Medicine, CUTFAM Research Center, Sivas, Turkey
dc.identifier.doi10.7197/cmj.830835
dc.identifier.doihttps://doi.org/10.7197/cmj.830835
dc.identifier.endpage483
dc.identifier.issn1305-0028
dc.identifier.issue4
dc.identifier.startpage479
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32838
dc.identifier.volume42
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectNeurotoxicity
dc.subjectcaptopril
dc.subjectPTZ
dc.titleEffect of captopril on the oxidative damage caused by pentylenetetrazole in the SHSY-5Y human neuroblastoma cell line
dc.typeResearch Article

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