Synthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine- 4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studies

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dc.contributor.authorBilgiçli, Ahmet T.
dc.contributor.authorBilgicli, Hayriye Genc
dc.contributor.authorHepokur, Ceylan
dc.contributor.authorGünsel, Armağan
dc.contributor.authorZengin, Mustafa
dc.contributor.authorYarasir, M. Nilüfer
dc.contributor.authorTüzün, Burak
dc.date.accessioned2022-05-13T09:02:53Z
dc.date.available2022-05-13T09:02:53Z
dc.date.issued9 March 2021tr
dc.departmentSivas Meslek Yüksekokulutr
dc.description.abstractIn this study, firstly, (4R)-2-(3-hydroxyphenyl)thiazolidine-4-carboxylic acid (1) and (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine-4-carboxylic acid (2) were prepared. Then, the novel type metallophthalocyanines (ZnPc (3), CuPc (4), and CoPc (5)) bearing thiazolidine groups in peripheral positions were synthesized using by compound (2). The synthesized new compounds (1–5) were characterized by the combination of standard spectroscopic methods such as FT-IR, 1H NMR, 13C NMR, UV–Vis spectral data, and MALDI-TOF. Aggregation behaviors of peripheral tetra-substituted metallophthalocyanines were investigated in dimethyl sulfoxide (DMSO) media. Fluorescence properties and fluorescence quantum yield of the new type zinc phthalocyanine (3) were performed in DMSO at room temperature. The anticancer activity of novel type metallophthalocyanines bearing thiazolidine groups in peripheral positions were investigated on rat glioma cancer (C6), human prostate carcinoma (DU-145), and normal human lung fibroblast (WI-38) cell lines. Finally, the biological and chemical activities of (4R)-2-(3-(3,4-dicyanophenoxy)phenyl)thiazolidine- 4-carboxylic acid (2) and its novel type metallophthalocyanines (ZnPc (3), CuPc (4), and CoPc (5)) have been compared with many parameters obtained using theoretical methods that are the Gaussian software and molecular docking.tr
dc.identifier.citation1Department of Chemistry, Sakarya University, Serdivan, Turkey 2Department of Basic Pharmaceutical Sciences, Division of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey 3Department of Chemistry, Sivas Cumhuriyet University, Sivas, Turkeytr
dc.identifier.startpagee6242tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13006
dc.identifier.volume35tr
dc.language.isoenen_US
dc.relation.ispartofApplied organometallic chemistryen_US
dc.relation.publicationcategoryUluslararası Editör Denetimli Dergide Makaletr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectanticancer activitiestr
dc.subjectDFTtr
dc.subjectMolecular dockingtr
dc.subjectphthalocyaninestr
dc.titleSynthesis of (4R)-2-(3-hydroxyphenyl)thiazolidine- 4-carboxylic acid substituted phthalocyanines: Anticancer activity on different cancer cell lines and molecular docking studiesen_US
dc.typeArticleen_US

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