The Role of Captopril on Pentylenetetrazole-Induced Seizures in Rats

Basit Öğe Kaydı
dc.contributor.authorÇiltaş, Arzuhan Çetindağ
dc.contributor.authorŞahin, Bilal
dc.date.accessioned2025-05-04T16:24:26Z
dc.date.available2025-05-04T16:24:26Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractABSTRACT: Purpose: In recent years, experimental studies have shown that some angiotensin-converting enzyme (ACE) inhibitors with antihypertensive effects have anticonvulsant effects against seizures. After the seizure, the process of inflammation begins in the brain and body, with the production of free radicals. Renin has some effects on the central nervous system of the angiotensin system. The current study's objective was to examine how captopril, an ACE inhibitor, affects neuroinflammation in the hippocampus and cortical areas in acute epileptic seizures and post-seizures induced by pentylenetetrazole (PTZ). Material and Methods: Eighteen Wistar Albino rats were separated into three groups: control, PTZ (serum physiologic 1 ml/kg as solvent), and captopril (50 mg/kg/day for 7days). To produce epileptic seizures, PTZ (45 mg/kg) was delivered thirty minutes after the drug was administered. The animals were monitored during 30 minutes to record seizures scoring scale and the onset time of first myoclonic jerk (FMJ). In the brain tissue, the activity of TNF- α, IL-1 β, NF-kB, COX-1, and COX-2 were examined. Results: Captopril increased FMJ onset time and reduced seizure stage as compared to the PTZ group (p
dc.description.abstract[No abstract available]
dc.identifier.doi10.51972/tfsd.1333472
dc.identifier.doihttps://doi.org/10.51972/tfsd.1333472
dc.identifier.endpage247
dc.identifier.issn2717-7173
dc.identifier.issue3
dc.identifier.startpage240
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32363
dc.identifier.volume4
dc.language.isoen
dc.publisherÜmit Muhammet KOÇYİĞİT
dc.relation.ispartofTurkish Journal of Science and Health
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectCaptopril
dc.subjectEpilepsy
dc.subjectPentylenetetrazole
dc.subjectNeuroinflammation
dc.subjectRat
dc.titleThe Role of Captopril on Pentylenetetrazole-Induced Seizures in Rats
dc.typeResearch Article

Dosyalar

Koleksiyon

DergiPark