The relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies

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dc.contributor.authorBulur, Oktay
dc.contributor.authorAksoy, Evrim Kahramanoğlu
dc.contributor.authorŞimşek, Gülçin Güler
dc.contributor.authorEser, Murat
dc.contributor.authorLülleci, Zeliha Asiltürk
dc.contributor.authorDal, Kürşat
dc.contributor.authorUzman, Metin
dc.date.accessioned2025-05-04T16:26:42Z
dc.date.available2025-05-04T16:26:42Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Several factors play role in colorectal carcinogenesis. Among these factors, helicobacter pylori infection is supposed to be one of the causative factors. Previous studies were focused on investigation of the relationship between helicobacter pylori existence and colon carcinomas by particular serological diagnostic tests. The aim of our study was to determine the effect of the helicobacter pylori infection and the severity of inflammation related to this infection on the colon carcinomas and non carcinoma colon mass lesions(tubular adenoma, tubulovillous adenoma, hyperplastic polyp).Method: A retrospective study was conducted at Kecioren Teaching - Research Hospital between 2010 to 2018. The files of 657 patients who underwent colonoscopy and were diagnosed as colon benign or malign mass lesions were examined retrospectively from the hospital database. Two hundred five patients who had undergone both upper gastrointestinal endoscopy and colonoscopies were included in the study. The presence and severity of inflammation due to helicobacter pylori were evaluated by histopathological examination of biopsies taken during upper gastrointestinal endoscopy. The severity of H. pylori inflammation was graded according to the Sydney classificationResults: In the comparison of colon carcinoma with other colon mass lesions group, there was no statistical significance in terms of gender (P= 0.094) and H. pylori serology (P= 0.998). However, the degree of inflammation was significantly high in patients with colon carcinoma than other colon mass lesions (P< 0.001).Conclusions: The fact that the severity of helicobacter pylori inflammation is higher in patients with colon carcinoma than patients with non-carcinoma colonic mass lesions suggests that inflammation due to helicobacter pylori may be more important than the presence of helicobacter pylori in the carcinogenesis of colon cancer.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.980147
dc.identifier.doihttps://doi.org/10.7197/cmj.980147
dc.identifier.endpage354
dc.identifier.issn1305-0028
dc.identifier.issue4
dc.identifier.startpage346
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32862
dc.identifier.volume43
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjecthelicobacter pylori
dc.subjectcolon carcinoma
dc.subjectinflammation
dc.titleThe relationship between severity of gastric inflammation due to Helicobacter pylori and colorectal malignancies
dc.typeResearch Article

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