Levetiracetam Protects Against Glutamate-Induced Excitotoxicity in SH-SY5Y Cell Line

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dc.contributor.authorÇiltaş, Arzuhan Çetindağ
dc.contributor.authorGündoğdu, Sema
dc.contributor.authorYulak, Fatih
dc.date.accessioned2025-05-04T16:23:08Z
dc.date.available2025-05-04T16:23:08Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description1919B012102071
dc.description.abstractThe latest research has shown that the new generation of antiepileptic drugs has neuroprotective on nervous system. On the other hand, the effect of levetiracetam, a new generation antiepileptic drug, on GIC in SH-SY5Y cells remains uncertain. This research aims to investigate the effect of levetiracetam on GIC and oxidant and antioxidant levels in SH-SY5Y cells. It is utilized SH-SY5Y cell line at this research. Four groups were formed to assess the impact of levetiracetam on SH-SY5Y cell death following GIC. While no treatment was administered to the control group, 10 mM glutamate was administered to the glutamate group for 24 hours (10, 25, 50 and 100 μg/ml). LEV at different concentrations was given to the levetiracetam for 24 hours. The levetiracetam + glutamate was pretreated with levetiracetam at several concentrations for 1 hour (10, 25, 50, and 100 μg/ml), which was followed by a 24-hour exposure to 10 mM glutamate. TAS and TOS levels in cells and cell viability were examined. Following the GIC, a 25 μg/ml-Levetiracetam improved cell viability in neuroblastoma cells dramatically (p < 0.05). LEV (25 ug/ml) + glutamate while enhanced TAS levels in neuroblastoma cells in comparison to the glutamate (p < 0.05), significantly reduced TOS levels (p < 0.05 Levetiracetam improves cell survival by reducing cell death following GIC in neuroblastoma cells. In the acute process, levetiracetam exerts a protective effect.
dc.description.abstract[No abstract available]
dc.description.sponsorshipTUBITAK 2209- A University Students Research Projects Support Program.
dc.identifier.doi10.47947/ijnls.1187054
dc.identifier.doihttps://doi.org/10.47947/ijnls.1187054
dc.identifier.endpage150
dc.identifier.issn2602-2478
dc.identifier.issn2602-2397
dc.identifier.issue2
dc.identifier.startpage142
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32158
dc.identifier.volume6
dc.language.isoen
dc.publisherUğur ÇAKILCIOĞLU
dc.relation.ispartofInternational Journal of Nature and Life Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectLevetiracetam
dc.subjectGlutamate
dc.subjectToxicity
dc.subjectSH-SY5Y
dc.subjectOxidative stress
dc.titleLevetiracetam Protects Against Glutamate-Induced Excitotoxicity in SH-SY5Y Cell Line
dc.typeResearch Article

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