Investigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer

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dc.contributor.authorTufa, Abdisa
dc.contributor.authorTaş, Ayça
dc.contributor.authorAğbektaş, Tuğba
dc.contributor.authorTopcu, Ömer
dc.contributor.authorGenet, Solomon
dc.contributor.authorSiliğ, Yavuz
dc.date.accessioned2025-05-04T16:26:41Z
dc.date.available2025-05-04T16:26:41Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: We aimed to analyzed the association between gastric cancer and polymorphism of XPO5 gene.Method: The polymorphism in the XPO5 gene (rs11544382) was determined in 120 individuals (60 gastric cancer patients; 60 healthy controls) using Real-Time PCR method.Results: The comparison of gastric cancer patients and controls revealed a statistically significant relationship for alcoholic drink consumption (p<0.05).The relationship between XPO5 gene (rs11544382) polymorphism and gastric cancer was statistically not significant. There was no a statistically significant relationship between mutant (GG) genotype with both wild type (AA) and heterozygous (AG) polymorphic genotypes when evaluated in XPO5 polymorphism gastric cancer patients and control groups (χ2:0.12, p=0.729). The heterozygous (AG) was dominant in gastric cancers patients and control subjects, 93.3 and 91.7% respectively.Conclusions: This study provides information about alleleand genotype frequency distribution of XPO5 gene polymorphism (rs11544382) in Turkish At the same time, AG genotype was found to be dominant in gastric cancer patients and their controls.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.907003
dc.identifier.doihttps://doi.org/10.7197/cmj.907003
dc.identifier.endpage262
dc.identifier.issn1305-0028
dc.identifier.issue3
dc.identifier.startpage254
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32852
dc.identifier.volume43
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectXPO5 gene
dc.subjectGastric cancer
dc.subjectpolymorphism
dc.subjectrs11544382
dc.titleInvestigation of the relationship between exportin5 (XPO5) polymorphism and gastric cancer
dc.typeResearch Article

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