EFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS

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dc.contributor.authorÇiltaş, Arzuhan Çetindağ
dc.contributor.authorÖztürk, Ayşegül
dc.date.accessioned2025-05-04T16:26:30Z
dc.date.available2025-05-04T16:26:30Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAbsract: The latest research have demonstrated that inflammation, oxidative stress and apoptosis plays a majör role in morphine analgesia and tolerance development. This search goals to examine the possible role of thiamine use on oxidative stress, inflammation and apoptosis in the development of morphine analgesia and morphine tolerance in rats. Methods: Thirty-six male Wistar rats were used in this study. The rats were severed into six groups: saline, 100 mg/kg thiamine, 5 mg/kg morphine, thiamine + morphine, morphine tolerance and thiamine + morphine tolerance. The resulting analgesic effect was measured by hot plate and tail movement analgesia tests. TAS and TOS, inflammation parameters, and apoptosis protein levels of the dorsal root ganglion tissues sample were measured using an ELISA kit. Results: When thiamine was given alone, it did not show anti-nociceptive effect (p>0.05). In addition, thiamine enhanced the analgesic effect of morphine (p < 0.05) and also significantly reduced tolerance to morphine (p < 0.05). However, it reduced TOS when administered with a single dose of morphine and tolerance induction (p < 0.05). In addition, thiamine reduced apoptosis protein levels after tolerance development (p < 0.05). Conclusion: Consequently, these results may attain by reducing TOS, inflammation, and apoptosis.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.1153681
dc.identifier.doihttps://doi.org/10.7197/cmj.1153681
dc.identifier.endpage34
dc.identifier.issn1305-0028
dc.identifier.issue1
dc.identifier.startpage25
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32751
dc.identifier.volume45
dc.language.isoen
dc.publisherSivas Cumhuriyet Üniversitesi
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectTiamine
dc.subjectMorphine Analgesia
dc.subjectMorphine Tolerance
dc.subjectTotal Antioxidant Status
dc.subjectTotal Oxidant Status
dc.subjectApoptosis
dc.subjectİnflammation
dc.titleEFFECT OF THİAMİNE ON MORPHİNE ANALGESİA AND TOLERANCE İN RATS
dc.typeResearch Article

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