Effect of Wheat Germ Oil on Wound Healing: An In Vitro Study in Fibroblast Cells

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dc.contributor.authorGömeç, Muhammed
dc.contributor.authorİpek, Gülnihal
dc.contributor.authorÖztürk, Ayşegül
dc.contributor.authorİnan, Deniz Şahin
dc.date.accessioned2025-05-04T16:24:25Z
dc.date.available2025-05-04T16:24:25Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description1919B012102114
dc.description.abstractPurpose: Wound healing is a set of mechanisms that are activated to restore structurally damaged tissue. There are many studies aimed at accelerating wound healing. In this context, products obtained from plants come to the fore. In this article, the effects of wheat germ oil (WGO), which is known to have antioxidant and anti-inflammatory properties, on wound healing were investigated by in vitro method. Material and Methods: Wheat germ oil and α-tocopherol were applied to L929, a healthy fibroblast cell line, at different doses for 24, 48 and 72 hours. Cell viability was measured by XTT colorimetric method. In vitro wound healing model was applied at the dose where the oil was effective. Obtained results were analyzed statistically. Results: As a result of the application of α-tocopherol to L929 cells at different doses, it was observed that there was no significant contribution to cell proliferation compared to the control group. However, WGO was observed to significantly increase proliferation at the 100 ng/ml concentration. In the wound healing model, cells treated with WGO at 48 hours were observed to proliferate faster and invade the wound site more rapidly. (p
dc.description.abstract[No abstract available]
dc.description.sponsorshipTÜBİTAK
dc.identifier.doi10.51972/tfsd.1128533
dc.identifier.doihttps://doi.org/10.51972/tfsd.1128533
dc.identifier.endpage235
dc.identifier.issn2717-7173
dc.identifier.issue3
dc.identifier.startpage230
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32354
dc.identifier.volume3
dc.language.isoen
dc.publisherÜmit Muhammet KOÇYİĞİT
dc.relation.ispartofTurkish Journal of Science and Health
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectCell viability
dc.subjectWheat germ oil
dc.subjectWound healing
dc.subjectα-tokoferole.
dc.titleEffect of Wheat Germ Oil on Wound Healing: An In Vitro Study in Fibroblast Cells
dc.typeResearch Article

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