PERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, (PFAPA) SYNDROME AND NLRP3 GENE ASSOCIATION

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dc.contributor.authorÜnsal, Gülşah
dc.date.accessioned2025-05-04T16:26:32Z
dc.date.available2025-05-04T16:26:32Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractPFAPA syndrome, which also includes aphthous stomatitis, pharyngitis, and adenitis, is the most common type of recurrent fever in children. Usually happens before the age of five. This syndrome is characterized by attacks lasting 3-7 days, recurring every 2-8 weeks with high fever (39 C and above) accompanied by at least one of the signs of aphthous stomatitis, pharyngitis, and/or cervical adenitis. Between attacks, the child is completely healthy.PFAPA is a benign disease that regresses with age. Steroids are used in the treatment of attacks. Colchicine is often preferred in prophylactic treatment. However, if there is no response to medical treatment, surgery (tonsillectomy) can be performed. Genetic and environmental factors are considered in the etiology. Genetic susceptibility concentrated on the genes for Familiar Mediterranean Fever (FMF, MEFV), TNF-Receptor-Associated Periodic Syndrome (TRAPS, gene TNFRF1A), HyperIgDSyndrome (HIDS, gene MVK), and Cryopyrin-Associated Periodic Syndrome (CAPS, gene NLRP3). But its etiology is still unknown.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.1310396
dc.identifier.doihttps://doi.org/10.7197/cmj.1310396
dc.identifier.issn1305-0028
dc.identifier.issue2
dc.identifier.startpage6-Jan
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32784
dc.identifier.volume45
dc.institutionauthorÜnsal, Gülşah
dc.language.isoen
dc.publisherSivas Cumhuriyet Üniversitesi
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectrecurrent fever
dc.subjectPFAPA
dc.subjectCHILD
dc.subjectNLRP3
dc.titlePERIODIC FEVER, APHTHOUS STOMATITIS, PHARYNGITIS, (PFAPA) SYNDROME AND NLRP3 GENE ASSOCIATION
dc.typeReview

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