Investigation of the potential antitumor activity of PLK1 inhibitor SBE13 in colon cancer cell line HT29

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dc.contributor.authorGömeç, Muhammed
dc.contributor.authorYulak, Fatih
dc.contributor.authorErgül, Mustafa
dc.date.accessioned2025-05-04T16:26:29Z
dc.date.available2025-05-04T16:26:29Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: High levels of Polo-like kinase 1 (PLK1), which are abnormally expressed in many tumor types, are known to contribute to tumorigenesis and poor prognosis. Therefore, specific targeting of PLK1 is an important strategy for cancer therapy. This study, it was aimed to investigate the cytotoxic effect of SBE13, one of the PLK1 inhibitors, against HT29 colon adenocarcinoma cells and its apoptotic potential.Methods: The cytotoxic effect of SBE13 on HT29 was determined by XTT colorimetric assay. Flow cytometry was also used to determine apoptosis.Results: SBE13 showed a dose-dependent cytotoxic effect in HT29 cells and its IC50 value was calculated as 11.79 µM for 48 h. Moreover, the Annexin V binding assay revealed that SBE13 treatment significantly increased apoptosis in HT29 cells.Conclusion: Generally, SBE13 exerts a cytotoxic effect promoted by apoptosis in colon cancer cells HT29. Although the anticancer efficacy of SBE13 in colon cancer is promising, this potential effect should be reinforced by further studies.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.1107200
dc.identifier.doihttps://doi.org/10.7197/cmj.1107200
dc.identifier.endpage222
dc.identifier.issn1305-0028
dc.identifier.issue2
dc.identifier.startpage218
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32744
dc.identifier.volume44
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectApoptosis
dc.subjectColon Cancer
dc.subjectPLK1 inhibition
dc.subjectSBE13.
dc.titleInvestigation of the potential antitumor activity of PLK1 inhibitor SBE13 in colon cancer cell line HT29
dc.typeResearch Article

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