The relationship between anti-Ro autoantibody positivity and the frequency of neurological involvement in Sjögren’s syndrome

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dc.contributor.authorDerin, Mehmet
dc.contributor.authorŞahin, Ali
dc.contributor.authorÇiğdem, Burhanettin
dc.contributor.authorCamcı, Ayşe
dc.contributor.authorSeven, Derya
dc.contributor.authorŞahin, Mehtap
dc.date.accessioned2025-05-04T16:26:41Z
dc.date.available2025-05-04T16:26:41Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: The aim of this study is to investigate the frequency of neurological and other involvement patterns of the Primary Sjögren’s syndrome (pSS).Method: Between June 2015 and January 2017, sixty SJS patients who were being followed up at Cumhuriyet University Medical Faculty Rheumatology-Internal Medicine Department were evaluated in the study. Their clinical complaints, glandular and extra-glandular findings, age, sex, other epidemiological data, Antinuclear antibody (ANA), Rheumatoid factor (RF), anti-Ro/La, Complemans (C3, C4), IgG, IgA, IgM levels were recorded.Results: The mean age of the patients was 47.7±1.3 years, and the mean age at diagnosis was 47.1±1.6 years. Of the SS patients, fifty-nine (98.3%) were female and one (1.7%) was male. The frequencies of the clinical symptoms were as follows: arthralgia in 81.7%, arthritis in 46.7%, and biopsy-proven vasculitic lesions in 5%. The frequencies of the neurological symptoms were as follows: headache in 68.75%, localized numbness in 6.25%, seizure in 6.25%, paresthesia in 12.5%, and loss of function in 6.25% (Figure 1). The total frequency of neurological involvement was 26.7 % in SjS patients. Peripheral nervous system involvement was seen in 8.3%. The findings of the magnetic resonance imaging of the patients with neurological involvement were non-specific gliotic lesions in 25%, periventricular lesions in 31.25%, parenchymal vasculitic lesions in 31.25%, and multiple sclerosis-like plaques in 12.5%. Anti-Ro positivity was found in 58.3%, RF in 53.3%, ANA in 78.3%, and low complement levels in 15%. However, anti-Ro positivity was lower in patients with neurological involvement than in patients without neurological involvement (p= 0.025).Conclusions: Neurological involvement should be kept in mind in patients diagnosed with SS. It can be seen more commonly than expected. In addition, further studies are needed to evaluate the mysterious role of anti-Ro autoantibody in SS patients with neurological involvement.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.909638
dc.identifier.doihttps://doi.org/10.7197/cmj.909638
dc.identifier.endpage158
dc.identifier.issn1305-0028
dc.identifier.issue2
dc.identifier.startpage152
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32853
dc.identifier.volume43
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectSjögren’s syndrome
dc.subjectneurological involvement
dc.subjectfrequency
dc.titleThe relationship between anti-Ro autoantibody positivity and the frequency of neurological involvement in Sjögren’s syndrome
dc.typeResearch Article

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