Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses

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dc.authorid0000-0002-8742-5145tr
dc.contributor.authorYılmaz, İsmet
dc.contributor.authorMaraş,Zeynep
dc.contributor.authorUğur, Yılmaz
dc.contributor.authorÖzgür, Mustafa Erkan
dc.contributor.authorDurmaz, Murat
dc.contributor.authorUlusoy, Halil İbrahim
dc.contributor.authorErdoğan, Selim
dc.date.accessioned2022-05-13T12:28:51Z
dc.date.available2022-05-13T12:28:51Z
dc.date.issued2021tr
dc.departmentEczacılık Fakültesitr
dc.description.abstractMetamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methyl amino antipyrine (MAA), an active primary metabolite of MT. The present study aims to determine the pharmacokinetic (PK) profiles of MT metabolites after intravenous (IV) and intramuscular (IM) administration into sex of Arabian horses (Equus ferus ca ballus) using a cross-over study design. The plasma samples were extracted by solid phase extraction (SPE) method, and plasma concentrations of MT metabolites were analyzed by high-performance liquid chromatography (HPLC). After administrations of MT, plasma concentrations of methylamino antipyrine (MAA), amino antipyrone (AA), and acetylamino antipyrone (AAA) were determined within range of 15 min 12 h. Plasma concentrations of AA and AAA were lower than the plasma concen trations of major metabolite MAA at each sampling point. The PK parameters were statistically evaluated for MT’s metabolites between male and female horses and also between IM and IV administrations of PK parameters such as Cmax, tmax, t1/2λz, AUC0-t , AUC0-∞, λz, Cl and Vss (p < .05). The AUCIM/AUCIV ratio in female and male horses for MAA was 1.19 and 1.13, respectively. The AUCIM/AUCIV ratio for AA was lower than those found for MAA. AUCIM/AUCIV ratio was statistically significantly different be tween male and female horses for AA (p < .05). According to these results, some PK parameters such as Cmax, AUC, and MRT, MAA and AA concentrations have shown statistically significant differences by MT administrations.tr
dc.identifier.endpage936tr
dc.identifier.startpage927tr
dc.identifier.urihttps://hdl.handle.net/20.500.12418/13080
dc.identifier.volume44tr
dc.language.isoenen_US
dc.relation.ispartofJournal of Veterinary Pharmacy and Threrapeuticsen_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Başka Kurum Yazarıtr
dc.rightsinfo:eu-repo/semantics/openAccesstr
dc.subjectArabian horses, HPLC, Metamizole, pharmacokinetics, solid-phase extractiontr
dc.titlePharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horsesen_US
dc.typeArticleen_US

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