Indicators of Isotretinoin-Induced Myopathy: Neutrophil/Lymphocyte Ratio, Cobb Angle of Spine

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dc.contributor.authorAraç, Densel
dc.contributor.authorGüner, Rukiye
dc.date.accessioned2025-05-04T16:19:08Z
dc.date.available2025-05-04T16:19:08Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: There are many side effects of isotretinoin on the musculoskeletal system, liver, nervous system and dermatological side effects. To investigate usage and side effects of isotretinoin (13-cis retinoic acid), which is popularly recommended by dermatologists for the treatment of acne vulgaris, on young patients admitted to the hospital with severe low back and neck pains.Methods: We evaluated 61 patients who, using isotretinoin for the treatment of acne vulgaris for an average of eight months, experienced cervical and lumbar pain between 2017-2019. The age range of patients was between 16 and 38 years, there were 45 female and 16 male patients. These patients used isotretinoin at a dose of 0.5-0.8 mg/kg/day for the treatment of acne vulgaris for about eight months. The patients were questioned about cervical and lower back pain, joint pain, muscle weakness, myoglobinuria, creatine phospo-kinase (CPK), Visual Analog Scale (VAS), inflammation myopathy, neutrophil/lymphocyte ratio (Neu/Lymp ratio), and Cobb angle of the spine during monthly controls.Results: The VAS and Neu/Lymp ratio, cervical and lumbar Cobb angles of the patients were statistically analyzed and the relationship between them was shown.Conclusion: The Neu/Lymp ratio and Cobb angle of the cervical and lumbar spine should be considered as an alternative or additional parameter to diagnose drug-induced myopathy.
dc.description.abstract[No abstract available]
dc.identifier.doi10.19127/mbsjohs.776897
dc.identifier.doihttps://doi.org/10.19127/mbsjohs.776897
dc.identifier.endpage304
dc.identifier.issn2149-7796
dc.identifier.issue3
dc.identifier.startpage299
dc.identifier.urihttps://hdl.handle.net/20.500.12418/31279
dc.identifier.volume6
dc.language.isoen
dc.publisherOrdu Üniversitesi
dc.relation.ispartofMiddle Black Sea Journal of Health Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectNeu/Lymp ratio
dc.subjectMyopathy
dc.subjectcob angle
dc.subjectinflamation
dc.subjectpain
dc.titleIndicators of Isotretinoin-Induced Myopathy: Neutrophil/Lymphocyte Ratio, Cobb Angle of Spine
dc.typeResearch Article

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