Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus

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dc.contributor.authorÖzden, Hüseyin
dc.contributor.authorGömeç, Muhammed
dc.contributor.authorŞahin, Yaşar
dc.contributor.authorKaraca, Gökhan
dc.contributor.authorBulut, Huri
dc.contributor.authorKilitci, Asuman
dc.date.accessioned2025-05-04T16:20:58Z
dc.date.available2025-05-04T16:20:58Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground/Aim: Tacrolimus is a commonly used agent for immunosuppression in organ transplantation with known nephrotoxic effects. We think that kidney-sparing therapy should be added to current treatment protocols. We aimed to observe the protective effect of resveratrol (RSV) against the adverse effects of tacrolimus (TAC) on rat kidneys. Methods: Twenty-four rats were randomly divided into the following three groups of eight rats each: Control, TAC, and RSV. The control group was not treated in any way. Tacrolimus was administered to the TAC group. In addition to tacrolimus use, resveratrol was administered to the RSV group. At the end of the experiment, one kidney was used for histopathological examination and the other, for biochemical examination. Results were analyzed statistically. Results: IL-1β, IL-6, TNF-Alpha levels in the control group were significantly lower than those in TAC and RSV groups (IL-1; P<0.001, P<0.001, IL-6; P<0.001 P=0.002, TNF-Alpha; P<0.001, P<0.001), and those in the RSV group were significantly lower than those in the TAC group (IL-1: P=0.032, IL-6: P=0.001 TNF-Alpha: P=0.026). TAS levels of the control group were significantly higher than those of the TAC group (P=0.030). TOS and OSI levels of the control group were significantly lower than those of the TAC and RSV groups (TOS: P=0.002, P=0.012, OSI: P=0.001, P=0.004). In histopathological evaluation, the TAC group showed the highest levels of fibrosis. The differences between the control and TAC groups and the TAC and RSV groups were statistically significant (P=0.003, P=0.003). Conclusion: Resveratrol has a protective effect against the adverse effects of tacrolimus on the kidney, which may be because of its anti-inflammatory and antioxidant properties.
dc.description.abstract[No abstract available]
dc.identifier.doi10.28982/josam.831592
dc.identifier.doihttps://doi.org/10.28982/josam.831592
dc.identifier.endpage148
dc.identifier.issn2602-2079
dc.identifier.issue2
dc.identifier.startpage144
dc.identifier.urihttps://hdl.handle.net/20.500.12418/31510
dc.identifier.volume5
dc.language.isoen
dc.publisherSelçuk BAŞAK
dc.relation.ispartofJournal of Surgery and Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectAnti-inflammatory
dc.subjectantioxidant
dc.subjectimmunosuppression
dc.subjectresveratrol
dc.subjecttacrolimus
dc.titleProtective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus
dc.typeResearch Article

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