Inflammatory and Biochemical Concepts in Children with Specific Learning Disorders: A Comparative Study

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dc.contributor.authorIşık, Cansu Mercan
dc.contributor.authorÇiçek, Ayla Uzun
dc.contributor.authorKaraarslan, Melih Uğur
dc.contributor.authorAkkuş, Serdar
dc.contributor.authorÖzbek, Dilara Ülger
dc.date.accessioned2025-05-04T16:18:50Z
dc.date.available2025-05-04T16:18:50Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study aimed to investigate the role of inflammation and biochemical parameters in children with Specific Learning Disorders (SLD) and to evaluate these parameters based on the severity of SLD.The study was planned as a retrospective. 39 children diagnosed with SLD and 32 healthy controls aged 6-16 years, who had hemogram and biochemistry tests performed at their admission, were included in the study. Diagnoses were based on DSM-5 criteria, clinical interviews, family interviews, and assessments of reading, writing, and math skills. The study received ethical approval from the Cumhuriyet University Non-Invasive Clinical Research Ethics Committee.Lymphocyte count and WBC were significantly higher in the SLD group (p = 0.003, p = 0.006, respectively). A significant difference was detected between the groups regarding platelet/lymphocyte ratio (PLR) (p = 0.047). No significant differences were found in blood parameters (erythrocyte, neutrophil, lymphocyte, WBC, platelet, T4, TSH, folic acid, vitamin B12, PLR, neutrophil/lymphocyte ratio (NLR)) when evaluated according to the severity of SLD.The results of our study suggest that inflammation may play a role in SLD, but further research with larger sample sizes, longitudinal designs, and comprehensive assessments of inflammatory markers is needed to better understand these associations.
dc.description.abstract[No abstract available]
dc.identifier.doi10.17776/csj.1521639
dc.identifier.doihttps://doi.org/10.17776/csj.1521639
dc.identifier.endpage672
dc.identifier.issn2587-2680
dc.identifier.issn2587-246X
dc.identifier.issue4
dc.identifier.startpage668
dc.identifier.urihttps://hdl.handle.net/20.500.12418/31155
dc.identifier.volume45
dc.language.isoen
dc.publisherSivas Cumhuriyet Üniversitesi
dc.relation.ispartofCumhuriyet Science Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectSLD
dc.subjectPLR
dc.subjectNLR
dc.subjectInflammation
dc.subjectBiochemical markers.
dc.titleInflammatory and Biochemical Concepts in Children with Specific Learning Disorders: A Comparative Study
dc.typeResearch Article

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