Affinity Recognition Based Gravimetric Nanosensor for Equilin Detection
| dc.authorid | 0000-0003-0900-035X | tr |
| dc.contributor.author | Aylaz, Gülgün | |
| dc.contributor.author | Andaç, Müge | |
| dc.date.accessioned | 2023-04-11T05:44:16Z | |
| dc.date.available | 2023-04-11T05:44:16Z | |
| dc.date.issued | 30 Mayıs 2022 | tr |
| dc.department | Mühendislik Fakültesi | tr |
| dc.description.abstract | The estrogenic hormones that are widely used in postmenopausal hormone supplements for women contaminate natural water resources. Equilin (Equ) is one of the estrogenic hormones that have a maximum contaminant level of 0.35 g/L in the chemical pollutants list. In this study, estrogenic hormones were precisely detected in a short time by affinity-recognition-based interactions in Quartz Crystal Microbalance (QCM) sensors. The QCM sensors were modified with 11-mercaptoundecanoic acid forming a self-assembled monolayer and with amino acids, namely tyrosine, tryptophan and phenylalanine. The affinity interactions between Equ and amino acids were studied using docking tools and confirmed by QCM experiments. The LODs of Equ were obtained as 4.59, 5.05 and 6.30 ng/L for tyrosine-, tryptophan- and phenylalanine-modified QCM nanosensors, respectively, with linear dynamic detection in the range of 25–500 nM. In terms of the LOD, selectivity and sensitivity calculations, the tyrosine-modified QCM nanosensor was found to have the highest performance for Equ detection compared to the tryptophan- and phenylalanine-modified ones. | tr |
| dc.identifier.citation | Gülgün Aylaz 1,2 and Müge Andaç 3,* 1 Graduate School of Science and Engineering, Hacettepe University, Beytepe, Ankara 06800, Turkey; gulgunaylaz@gmail.com 2 Nanotechnology and Nanomedicine Division, Hacettepe University, Beytepe, Ankara 06800, Turkey 3 Environmental Engineering Department, Hacettepe University, Bey | tr |
| dc.identifier.endpage | 21 | tr |
| dc.identifier.issue | 172 | tr |
| dc.identifier.startpage | 1 | tr |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/13482 | |
| dc.identifier.volume | 10 | tr |
| dc.language.iso | en | en_US |
| dc.publisher | MDPI | tr |
| dc.relation.ispartof | Chemosensors | en_US |
| dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.subject | equilin | tr |
| dc.subject | molecular docking; quartz crystal microbalance (QCM) | tr |
| dc.subject | endocrine disrupting chemicals (EDCs) | tr |
| dc.subject | affinity-recognition-based sensor | tr |
| dc.title | Affinity Recognition Based Gravimetric Nanosensor for Equilin Detection | en_US |
| dc.type | Article | en_US |
