Assessment of the antinociceptive effects of cannabinoid receptor agonists SER 601 and L-759,633 in an acute pain model in rats

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dc.contributor.authorJoha, Zıad
dc.contributor.authorYıldırım, Şahin
dc.contributor.authorSaraç, Bülent
dc.date.accessioned2025-05-04T16:26:41Z
dc.date.available2025-05-04T16:26:41Z
dc.date.issued2021
dc.departmentSivas Cumhuriyet Üniversitesi
dc.descriptionT848
dc.description.abstractA poorly managed pain is associated with many negative results. These results disturb patients, their families and societies. Although opioid agents have extraordinary analgesic efficacy, they may cause serious adverse consequences. For medication of pain, there is a medical need to discover possible alternatives to opioids. In animal models of acute pain synthetic cannabinoid receptor agonists demonstrated analgesic effects. Selective activation of the cannabinoid 2 receptor in the rodent models does not cause psychotropic effects therefore CB2R agonists are an appealing target for the medication of pain and other pathologies. In this study we examined the antinociceptive activity of cannabinoid receptor 2 (CB2) agonists SER 601 and L-759,633 in different doses in rat models of acute pain using the hot plate and tail flick tests. These two agents exhibited dose-dependent antinociceptive effects in acute pain model. The analgesic effects of the administrated doses of L-759,633 and SER 601 reached their peak at 60 min. In the tail flick test, the antinociceptive effects of 3, 6 and 12 mg / kg SER601 in the acute pain were more than the L-759,633 groups at the same doses.
dc.description.abstract[No abstract available]
dc.description.sponsorshipCumhuriyet University Scientific Research Project
dc.identifier.doi10.7197/cmj.870286
dc.identifier.doihttps://doi.org/10.7197/cmj.870286
dc.identifier.endpage48
dc.identifier.issn1305-0028
dc.identifier.issue1
dc.identifier.startpage41
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32844
dc.identifier.volume43
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectAcute Pain
dc.subjectCannabinoid Receptor 2 Agonists
dc.subjectTail Flick
dc.subjectHot Plate
dc.titleAssessment of the antinociceptive effects of cannabinoid receptor agonists SER 601 and L-759,633 in an acute pain model in rats
dc.typeResearch Article

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