Browsing by Author "Altun, Ahmet"
Now showing items 21-29 of 29
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Ineffective Doses of Dexmedetomidine Potentiates the Antinociception Induced by Morphine and Fentanyl in Acute Pain Model
Unal, Mumin; Gursoy, Sinan; Altun, Ahmet; Duger, Cevdet; Kol, Iclal Ozdemir; Kaygusuz, Kenan; Bagcivan, Ihsan; Mimaroglu, Caner (KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, 2013)The aim of this study was to evaluate the synergistic potentiation effect of ineffective doses of dexmedetomidine on antinociception induced by morphine and fentanyl in acute pain model in rats. Seventy albino Wistar rats ... -
Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium
Ergul, Merve; Turgut, Nergiz H.; Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Bagcivan, Ihsan (ELSEVIER SCIENCE BV, 2016)Objectives: Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction. The ... -
Investigation of Antitumor Effects of Sorafenib and Lapatinib Alone and in Combination on MCF-7 Breast Cancer Cells
Kacan, Turgut; Altun, Ahmet; Altun, Gulsah Gultekin; Kacan, Selen Baloglu; Sarac, Bulent; Seker, Mehmet Metin; Bahceci, Aykut; Babacan, Nalan (ASIAN PACIFIC ORGANIZATION CANCER PREVENTION, 2014)Background: Breast cancer evolution and tumor progression are controlled by complex interactions between steroid receptors and growth factor receptor signaling. Aberrant growth factor receptor signaling can augment or ... -
Investigation of Relaxant Effects of New Agents Affecting Nitric Oxide/Cyclic Guanosine Monophosphate Pathway on Sheep Oddi Sphincter
Sarac, Bulent; Durmus, Nedim; Bagcivan, Ihsan; Altun, Ahmet; Turan, Mustafa; Sencan, Mehmet (LIPPINCOTT WILLIAMS & WILKINS, 2010)Objectives: Nitric oxide (NO) is a potent nonadrenergic, noncholinergic mediator of gastrointestinal smooth muscle. We aimed to investigate the effects of new NO/cyclic guanosine monophosphate (cGMP) pathway-affecting ... -
Investigation of the Relaxant Effect Mechanism of Ketamine on Normal and Ovalbumin-Induced Trachea in Guinea Pigs
Sarac, Bulent; Altun, Ahmet; Yildirim, Sahin; Yildirim, Mustafa Kemal; Temiz, Tijen Kaya; Bagcivan, Ihsan; Sencan, Mehmet (ORTADOGU AD PRES & PUBL CO, 2011)Objective: The aim of this study was to investigate of effects and the possible mechanisms of effects of ketamine on the isolated trachea preparations from control and ovalbumin sensitized guinea pigs. Material and Methods: ... -
Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft
Sarac, Bulent; Korkmaz, Ozge; Altun, Ahmet; Bagcivan, Ihsan; Goksel, Sabahattin; Yildirim, Sahin; Berkan, Ocal (OXFORD UNIV PRESS, 2015)In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary artery is the first choice of arterial graft, and the second choice is the radial artery (RA). Unfortunately, RA spasms ... -
The nitric oxide-cGMP signaling pathway plays a significant role in tolerance to the analgesic effect of morphine
Ozdemir, Ercan; Bagcivan, Ihsan; Durmus, Nedim; Altun, Ahmet; Gursoy, Sinan (CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS, 2011)Although the phenomenon of opioid tolerance has been widely investigated, neither opioid nor nonopioid mechanisms are completely understood. The aim of the present study was to investigate the role of the nitric oxide ... -
Zimelidine attenuates the development of tolerance to morphine-induced antinociception
Ozdemir, Ercan; Gursoy, Sinan; Bagcivan, Ihsan; Durmus, Nedim; Altun, Ahmet (WOLTERS KLUWER MEDKNOW PUBLICATIONS, 2012)Objectives: The aim of this study was to investigate effect of zimelidine (a serotonin reuptake inhibitor) on morphine-induced tolerance in rats. Materials and Methods: Male Wistar albino rats weighing 160-180 g were used ...